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1.
Akimitsu Ishizawa Ming Zhou Ryoji Suzuki Hiroshi Abe 《Anatomical science international / Japanese Association of Anatomists》2014,89(3):183-190
We dissected the atrial arterial system of 22 adult human hearts from donated cadavers. Atrial branches (ABs) of coronary arteries, more than 0.5 mm in diameter at their origin, were selected to trace systematically their origin and course. A total of 135 ABs were observed, of which 68 were from the circumflex branch, and 67 from the right coronary artery. The origins of ABs were classified into the following five regions where they arose from coronary arteries: (A) from the left aortic bulb to the one-third of the left auricle, (B) from the end of region A to the point of anastomosis of the coronary sinus (CS) with an oblique vein of the left atrium (OVLA), (C) from the end of region B to the opening of the CS, (D) from the end of region C to two-thirds of the right auricle, (E) from the end of region D to the right aortic bulb. With regard to the course of the ABs, they were classified according to the following 8 areas where they passed: (I) underneath Bachmann’s bundle (BB); (II) the area connecting the right and left superior pulmonary veins; (III) the dorsal part of the interatrial septum; (IV) beside the OVLA; (V) the atrial side beside the CS; (VI) the ventral part of the interatrial septum; (VII) the dorsal wall of the left atrium; (VIII) on the dorsal surface of the right atrium. Thus, ABs showed various combinations of regions and courses. 相似文献
2.
Zhiyun Zheng Sheng Gao Zhe Yang Haiyang Xie Cheng Zhang Bingyi Lin Liming Wu Shusen Zheng Lin Zhou 《International journal of medical sciences》2014,11(2):142-150
Background: The newly identified metastasis-associated in colon cancer-1 (MACC1) gene is involved in angiogenesis, epithelial-to-mesenchymal transition (EMT), invasiveness, and metastasis in a variety of malignancies. Overexpression of MACC1 gene is a prognostic marker for poor outcome of hepatocellular carcinoma (HCC) patients. However, the association between genetic polymorphisms of MACC1 gene and poor outcome in HCC has been not been performed. We therefore investigated the correlation of MACC1 single nucleotide polymorphisms (SNPs) with tumor recurrence and overall survival in HCC patients undergoing liver transplantation (LT). Methods: The study included 187 HCC patients treated with LT. Five polymorphisms in the MACC1 gene (rs1990172, rs3735615, rs4721888, rs2241056, rs975263) were genotyped in 183 cases of tumorous tissue sample and 117 cases of adjacent normal tissue sample using SNaP-Shot assays. The association of SNPs with tumor recurrence and overall survival was then analyzed by additive, dominant, recessive, and overdominant models in a cohort of 156 HCC patients. Results: In terms of tumor recurrence, heterozygous of SNP rs1990172 and SNP rs975263 showed a significant high risk of relapse using univariate and multivariate analysis (overdominant, HR(95%CI)=2.27 [1.41-3.66], P=0.001; HR(95%CI)=2.16 [1.37-3.39], P=0.001). But the difference between heterozygous of these two SNPs and overall survival did not reach a significance in all models. The other three investigated SNPs were not significantly associated with tumor recurrence and overall survival (P>0.05). In addition, we found no significant difference in genotype frequencies between HCC and controls. Conclusions: Our data suggest that SNP rs1990172 and SNP rs975263 in the MACC1 gene may be potential genetic markers for HCC recurrence in LT patients. 相似文献
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Neng Yang Zuoqing Li Zhijun Jiao Peng Gu Yun Zhou Liming Lu Kuang-Yen Chou 《Clinical immunology (Orlando, Fla.)》2014,153(2):277-287
A group of 15-aa-long Trichosanthin-derived peptides was synthesized and screened based on their differential abilities to induce low-responsiveness in mouse strains with high and low susceptibility. One of them was conjugated to form a homo-tetramer Tk-tPN. At concentrations of 0.1–50 μg/ml, Tk-tPN activated CD8+CD28− Tregs in vitro to induce immune suppression as effectively as the native Trichosanthin but did not exhibit cytotoxicity. In EAE mice which were pre-treated with Tk-tPN or Tk-tPN-activated CD8+ T cells, a marked attenuation of clinical scores was recorded together with an expansion of the CD8+CD28− Treg from 2.2% to 36.1% in vivo. A pull-down assay and signal transduction analyses indicated that the ability of Tk-tPN to convert the CD8+CD28− Treg-related cytokine secretion pattern from type 1 to type 2 depends on the TLR2-initiated signaling in macrophages. The high production of IL-4/IL-10 by the Tk-tPN-activated CD8+CD28− Treg suggests the value of using Tk-tPN as a therapeutic reagent for Th1-dominant immunological diseases. 相似文献
6.
Jiang-Min Ma Ting-Jun Zhou Ran Wang Jing Shan Yu-Nong Wu Xiao-Ling Song Ning Gu Yuan Fan 《European archives of oto-rhino-laryngology》2014,271(12):3291-3295
Oral and pharyngeal cancer is the sixth most common cancer worldwide, the 5-year survival rate has not yet increased. A key factor in rates not having improved is the lack of early detection. This study was undertaken to estimate the diagnostic accuracy of brush biopsy with DNA-image cytometry (a noninvasive method) for potentially malignant oral disorders compared with tissue biopsy pathology in China. Exfoliative cells were obtained using a cytobrush cell collector from oral mucosa of 52 subjects, followed by scalpel biopsy from the same region. Nuclear DNA contents (ploidy) were measured after Feulgen restaining, using an automated DNA image cytometer. Exfoliative cytology with DNA-image cytometry and histopathological diagnosis were performed separately at different institutions. Histological investigation was considered the gold standard. We reported that the sensitivity of DNA aneuploidy for the detection of cancer cells in potentially malignant oral disorders was 86.36 %, its specificity was 90.00 %, its positive predictive value was 86.36 %, and its negative predictive value was 90.00 %. Brush biopsy with DNA-image cytometry is a useful method for monitoring potentially malignant oral disorders. 相似文献
7.
目的:研究语速是否对可接受噪声级(acceptable noise level,ANL)测试产生影响。方法选取国家普通话水平测试用朗读作品的音频材料,制作出0.8、1和1.2倍语速的 ANL 测试材料,对58名听力正常的青年人进行3种语速测试材料的 ANL 测试,分别获得最舒适响度级(most comfortable loudness,MCL),最大背景噪声级(background noise level,BNL),并根据 ANL=MCL—BNL 计算出 ANL 值,进行统计学分析。结果0.8、1和1.2倍语速条件下 ANL 值分别为2.88±3.81、2.76±3.76、3.16±3.72 dB HL,三种语速下的 MCL、BNL、ANL 值差异无统计学意义(P>0.05),0.8、1和1.2倍语速条件下 MCL 与 ANL 均无相关关系(P>0.05),BNL 与 ANL均呈负相关(P<0.01)。结论本研究发现三种语速 ANL 测试材料的语速并不影响 ANL 值;个体接受背景噪声的能力越强,其 ANL 值越小。 相似文献
8.
Hong Zhu Xuehui Tang Wei Wei Adel Maklad William Mustain Richard Rabbitt Steve Highstein Jerome Allison Wu Zhou 《Journal of the Association for Research in Otolaryngology》2014,15(1):73-86
Sound-evoked vestibular myogenic potentials recorded from the sternocleidomastoid muscles (the cervical vestibular-evoked myogenic potential or cVEMP) and the extraocular muscles (the ocular VEMP or oVEMP) have proven useful in clinical assessment of vestibular function. VEMPs are commonly interpreted as a test of saccular function, based on neurophysiological evidence showing activation of saccular afferents by intense acoustic click stimuli. However, recent neurophysiological studies suggest that the clicks used in clinical VEMP tests activate vestibular end organs other than the saccule. To provide the neural basis for interpreting clinical VEMP testing results, the present study examined the extent to which air-conducted clicks differentially activate the various vestibular end organs at several intensities and durations in Sprague–Dawley rats. Single unit recordings were made from 562 vestibular afferents that innervated the otoliths [inferior branch otolith (IO) and superior branch otolith (SO)], the anterior canal (AC), the horizontal canal (HC), and the posterior canal (PC). Clicks higher than 60 dB SL (re-auditory brainstem response threshold) activated both semicircular canal and otolith organ afferents. Clicks at or below 60 dB SL, however, activated only otolith organ afferents. Longer duration clicks evoked larger responses in AC, HC, and SO afferents, but not in IO afferents. Intra-axonal recording and labeling confirmed that sound sensitive vestibular afferents innervated the horizontal and anterior canal cristae as well as the saccular and utricular maculae. Interestingly, all sound sensitive afferents are calyx-bearing fibers. These results demonstrate stimulus-dependent acoustic activation of both semicircular canals and otolith organs, and suggest that sound activation of vestibular end organs other than the saccule should not be ruled out when designing and interpreting clinical VEMP tests. 相似文献
9.
目的:研究单侧睾丸扭转后对侧睾丸的形态学和生物化学改变,探讨不同处理方式对健侧睾丸形态功能的影响.方法:SD大鼠随机分为假手术组、扭转复位组和扭转切除组,依Turner法建立左侧睾丸扭转模型,24 h后采集对侧睾丸标本进行H-E染色、TUNEI染色和caspase-3活性测定;6、12h和24 h后收集对侧睾丸,进行细胞因子和丙二醛检测.结果:扭转复位组对侧睾丸细胞凋亡数量与切除组相比显著增多,丙二醛含量增加,caspase-3活性增强,炎症因子含量增加.结论:睾丸扭转后及时手术切除损伤睾丸能够有效保护健侧睾丸的发育和功能. 相似文献
10.
Yan-Hua Zhai Li Zhou Yang Wang Zhong-Wei Wang Zhi Li Xiao-Juan Zhang Jian-Fang Gui 《Parasitology research》2014,113(4):1331-1341
Some myxosporeans have been demonstrated to be harmful to worldwide aquaculture. However, the proliferation information has remained unclear in the fish hosts. In this study, we utilized the mix-culturing equality to reveal significant difference in disease assistance between two different clones of gibel carp, in which clone D had been cultured for nearly 40 years, whereas clone A+ was a newly created clone. According to morphological and genetic analysis of isolated spores, the diseasing pathogen was identified as Myxobolus wulii of the genus Myxobolus in Myxosporea. Subsequently, a polyclonal antibody specific to soluble proteins of the purified spores was generated. Using the antibody, we performed immunofluorescence observation of the liver lump sections sampled from the heavily diseased clone D individuals, and found that the liver lumps were completely composed of numerous honeycomb-like cysts, full of maturing and mature myxosporean spores, and almost all of liver tissues were destroyed. Comparative co-localization detection revealed a significantly inducing expression of apo-14 protein around the infected myxosporean sporoplasms and plasmodia, and the inducing level was much stronger in clone A+ than in clone D. Furthermore, a primarily screening of 15 different major histocompatibility complex class Iα variants also excavated major variants that respectively belong to clones D and A+. Therefore, these data provide significant information for differences in myxosporean proliferation and disease resistance in fish clone hosts with different genetic background. Further studies on myxosporean development and the mechanism for disease resistance will be very important for preventing and controlling the parasitic myxosporean disease. 相似文献