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排序方式: 共有1038条查询结果,搜索用时 15 毫秒
1.
Yuichiro Soma Hirotaka Mutsuzaki Tomokazu Yoshioka Shigeki Kubota Yukiyo Shimizu Akihiro Kanamori Masashi Yamazaki 《Journal of Physical Therapy Science》2021,33(1):84
[Purpose] The aim of this report was to describe the safety, feasibility, and efficacy of rehabilitation by knee extension and flexion training using the knee single-joint hybrid assistive limb in a patient after anterior cruciate ligament reconstruction. [Participant and Methods] A 33 year-old male underwent an arthroscopic procedure for anatomic single-bundle anterior cruciate ligament reconstruction with a semitendinosus tendon autograft. Rehabilitation training using the knee single-joint hybrid assistive limb was initiated at postoperative week 18 and repeated weekly for 3 weeks. The patient performed five sets of the knee single-joint hybrid assistive limb-assisted knee-extension-flexion exercises per session at a frequency of 10 exercises/set. [Results] The peak extension torque at all velocities with the limb symmetry index was higher after the hybrid assistive limb intervention (post-intervention) than before using it (pre-intervention). Peak flexion torques at 60°/s and 300°/s of limb symmetry index were higher post-intervention than pre-intervention. The range of motion in extension and flexion improved from −2° (pre-intervention) to −1° (post-intervention) and from 124° to 133°, respectively. The Lysholm score increased from 58 (pre-intervention) to 94 (post-intervention). [Conclusion] The knee single-joint hybrid assistive limb can be used safely for anterior cruciate ligament reconstruction training, without any adverse events. Our results indicate that the knee single-joint hybrid assistive limb training may improve muscle function, effectively overcoming dysfunction.Key words: The single-joint type hybrid assistive limb for the knee joint (knee HAL-SJ), Anterior cruciate ligament reconstruction, Muscle dysfunction 相似文献
2.
Haruna Makita Kazuhira Endo Yoshiya Kasahara Asuka Nakata Makiko Moriyama-Kita Kazuya Ishikawa Takayoshi Ueno Yosuke Nakanishi Satoru Kondo Naohiro Wakisaka Noriko Gotoh Tomokazu Yoshizaki 《Oncology Letters》2021,21(5)
Rodent models mimic the heterogeneity of head and neck cancer (HNC) malignancies and are used to investigate HNC-associated biomarkers and evaluate drug responses. To assess the utility of patient-derived xenografts (PDXs) as an HNC model, 18 tumour samples were obtained from surgical specimens of patients with HNC and implanted into non-obese diabetic severe combined immunodeficient mice. The histological features of PDXs and corresponding patient samples were compared. Furthermore, the present study investigated how PDX responses to anticancer drugs mimic patient clinical responses, as well as the expression of adenosine triphosphate-binding cassette transporters through chemotherapy in an HNC-PDX model. A total of five PDXs from patients with HNC exhibiting high correspondence with histopathological features of the original patient samples were established (establishment rate, 28%). The responses of three PDXs to cisplatin were associated with clinical responses of the patients. ABC transporter expression was augmented in one PDX model after anticancer drug treatment, but not in PBS-treated passaged PDXs. PDX models exhibited similar biological and chemosensitive characteristics to those of the primary tumours. PDXs could be a useful preclinical tool to test novel therapeutic agents and identify novel targets and biomarkers in HNC. 相似文献
3.
Junryo Rii MD Shinichi Sakamoto MD PhD Yasutaka Yamada MD PhD Nobushige Takeshita MD Satoshi Yamamoto MD PhD Tomokazu Sazuka MD PhD Yusuke Imamura MD PhD Kazuyoshi Nakamura MD PhD Akira Komiya MD PhD Atsushi Komaru MD PhD Satoshi Fukasawa MD PhD Hiroomi Nakatsu MD PhD Koichiro Akakura MD PhD Tomohiko Ichikawa MD PhD 《The Prostate》2020,80(11):850-858
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Potential associations between perihepatic lymph node enlargement and liver fibrosis,hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection 下载免费PDF全文
6.
Role of 3‐D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma 下载免费PDF全文
Hatsue Fujino Tomoki Kimura Hiroshi Aikata Daisuke Miyaki Tomokazu Kawaoka Hiromi Kan Takayuki Fukuhara Tomoki Kobayashi Noriaki Naeshiro Yohji Honda Masataka Tsuge Akira Hiramatsu Michio Imamura Yoshiiku Kawakami Hideyuki Hyogo Shoichi Takahashi Rika Yoshimatsu Takuji Yamagami Masahiro Kenjo Yasushi Nagata Kazuo Awai Kazuaki Chayama 《Hepatology research》2015,45(6):607-617
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Masumoto Yoshinobu Fukunishi Shigeo Fukui Tomokazu Yoshiya Shinichi Nishio Shoji Fujihara Yuki Okahisa Shohei Okada Taishi Kanto Makoto Goshi Ariha Morio Futoshi Takeda Yu 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(3):465-472
European Journal of Orthopaedic Surgery & Traumatology - Combined anteversion (CA) technique (stem-first procedure) is generally accepted as the optimal technique to attain an appropriate CA... 相似文献
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10.
Chen Wang Yukari Okita Ling Zheng Yasuhiro Shinkai Lev Manevich Jas M. Chin Tomokazu Kimura Hiroyuki Suzuki Yoshito Kumagai Mitsuyasu Kato 《Cancer science》2021,112(10):4187-4197
Breast cancer is the most common cancer among women. Glycoprotein non–metastatic melanoma protein B (GPNMB), a type I transmembrane protein that is highly expressed in many cancers, including breast cancer, has been shown to be a prognostic factor. We previously reported that GPNMB overexpression confers tumorigenic potential, as evidenced by invasive tumor growth in vivo, sphere formation, and cellular migration and invasion to non–tumorigenic mammary epithelial cells. In this study, we focused on the serine (S) residue in the intracellular domain of GPNMB (S530 in human isoform b and S546 in mouse), which is predicted to be a phosphorylation site. To investigate the roles of this serine residue, we made an antibody specific for S530-phosphorylated human GPNMB and a point mutant in which S530 is replaced by an alanine (A) residue, GPNMB(SA). Established GPNMB(SA) overexpressing cells showed a significant reduction in sphere formation in vitro and tumor growth in vivo as a result of decreased stemness-related gene expression compared to that in GPNMB(WT)-expressing cells. In addition, GPNMB(SA) impaired GPNMB-mediated cellular migration. Furthermore, we found that tyrosine kinase receptor signaling triggered by epidermal growth factor or fibroblast growth factor 2 induces the serine phosphorylation of GPNMB through activation of downstream oncoproteins RAS and RAF. 相似文献