收费全文 | 2671篇 |
免费 | 203篇 |
国内免费 | 17篇 |
耳鼻咽喉 | 56篇 |
儿科学 | 59篇 |
妇产科学 | 22篇 |
基础医学 | 301篇 |
口腔科学 | 49篇 |
临床医学 | 149篇 |
内科学 | 674篇 |
皮肤病学 | 30篇 |
神经病学 | 243篇 |
特种医学 | 99篇 |
外科学 | 536篇 |
综合类 | 8篇 |
预防医学 | 74篇 |
眼科学 | 93篇 |
药学 | 196篇 |
中国医学 | 3篇 |
肿瘤学 | 299篇 |
2023年 | 24篇 |
2022年 | 15篇 |
2021年 | 84篇 |
2020年 | 51篇 |
2019年 | 65篇 |
2018年 | 85篇 |
2017年 | 70篇 |
2016年 | 77篇 |
2015年 | 73篇 |
2014年 | 96篇 |
2013年 | 115篇 |
2012年 | 190篇 |
2011年 | 213篇 |
2010年 | 115篇 |
2009年 | 103篇 |
2008年 | 179篇 |
2007年 | 157篇 |
2006年 | 144篇 |
2005年 | 158篇 |
2004年 | 153篇 |
2003年 | 148篇 |
2002年 | 145篇 |
2001年 | 40篇 |
2000年 | 34篇 |
1999年 | 27篇 |
1998年 | 32篇 |
1997年 | 27篇 |
1996年 | 23篇 |
1995年 | 22篇 |
1994年 | 25篇 |
1993年 | 12篇 |
1992年 | 14篇 |
1991年 | 13篇 |
1990年 | 17篇 |
1989年 | 19篇 |
1988年 | 22篇 |
1987年 | 18篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 11篇 |
1983年 | 8篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1978年 | 3篇 |
1975年 | 4篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1968年 | 3篇 |
Purpose
Currently, several therapeutic options for castration-resistant prostate cancer (CRPC) are available, for which predictive biomarkers have not been established. Therefore, we aimed to reveal the association between pretreatment serum testosterone level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC.Patients and methods
The present study included Japanese patients with metastatic prostate cancer whose serum testosterone levels during androgen-deprivation therapy were available. The antitumor outcomes when treated with enzalutamide, abiraterone, docetaxel, and cabazitaxel with clinicopathological parameters including serum testosterone levels during androgen-deprivation therapy, as well as prognoses including progression-free survival and overall survival, were examined.Results
Progression-free survival among men with higher serum testosterone level was superior to that among men with lower serum testosterone level when treated with enzalutamide. On the contrary, progression-free survival and overall survival among men with higher serum testosterone level were significantly inferior to those among men with lower serum testosterone level when treated with docetaxel and cabazitaxel, respectively.Conclusions
The present study indicated distinct prognostic values of serum testosterone level when treated with androgen receptor axis-targeting agent and taxane chemotherapy for CRPC, suggesting that serum testosterone level may be useful predictive biomarker to navigate the appropriate therapy in patients with CRPC. 相似文献2. The metabolism of selexipag was also studied in bile-duct-cannulated rats and dogs after a single oral and intravenous dose of [14C]selexipag. MRE-269 acyl glucuronide was found in both rat and dog bile. Internal acyl migration reactions of MRE-269 glucuronide were identified in an experiment with the synthetic standard MRE-6001.
3. MRE-269 was the major component in the faeces of rats and dogs. In ex vivo study using rat and dog faeces, selexipag hydrolysis to MRE-269 by the intestinal microflora is considered to be a contributory factor in rats and dogs.
4. A taurine conjugate of MRE-269 was identified in rat bile sample. Overall, selexipag was eliminated via multiple routes in animals, including hydrolysis, oxidative metabolism, conjugation, intestinal deconjugation, and gut flora metabolism. 相似文献