全文获取类型
收费全文 | 5556篇 |
免费 | 361篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 494篇 |
妇产科学 | 145篇 |
基础医学 | 575篇 |
口腔科学 | 145篇 |
临床医学 | 346篇 |
内科学 | 1412篇 |
皮肤病学 | 118篇 |
神经病学 | 326篇 |
特种医学 | 162篇 |
外科学 | 905篇 |
综合类 | 169篇 |
一般理论 | 2篇 |
预防医学 | 220篇 |
眼科学 | 134篇 |
药学 | 271篇 |
中国医学 | 9篇 |
肿瘤学 | 464篇 |
出版年
2023年 | 45篇 |
2022年 | 46篇 |
2021年 | 196篇 |
2020年 | 123篇 |
2019年 | 184篇 |
2018年 | 224篇 |
2017年 | 168篇 |
2016年 | 179篇 |
2015年 | 183篇 |
2014年 | 258篇 |
2013年 | 344篇 |
2012年 | 472篇 |
2011年 | 500篇 |
2010年 | 300篇 |
2009年 | 205篇 |
2008年 | 339篇 |
2007年 | 333篇 |
2006年 | 280篇 |
2005年 | 244篇 |
2004年 | 212篇 |
2003年 | 163篇 |
2002年 | 175篇 |
2001年 | 91篇 |
2000年 | 115篇 |
1999年 | 77篇 |
1998年 | 40篇 |
1997年 | 27篇 |
1996年 | 27篇 |
1995年 | 21篇 |
1994年 | 20篇 |
1993年 | 14篇 |
1992年 | 37篇 |
1991年 | 47篇 |
1990年 | 24篇 |
1989年 | 38篇 |
1988年 | 22篇 |
1987年 | 24篇 |
1986年 | 15篇 |
1985年 | 17篇 |
1984年 | 12篇 |
1983年 | 13篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1977年 | 5篇 |
1976年 | 11篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1972年 | 7篇 |
1971年 | 5篇 |
排序方式: 共有5932条查询结果,搜索用时 15 毫秒
1.
2.
Schaefer Jordan K. Barnes Geoffrey D. Sussman Jeremy B. Saini Sameer D. Caverly Tanner J. Read Susan Zikmund-Fisher Brian J. Kurlander Jacob E. 《Journal of thrombosis and thrombolysis》2022,54(4):639-646
Journal of Thrombosis and Thrombolysis - Recent trials suggest that aspirin for primary prevention may do more harm than good for some, including adults over 70 years of age. We sought to... 相似文献
3.
4.
5.
6.
Facundo Davaro Jacob Roberts Allison May Coleman McFerrin Sameer Siddiqui Zachary Hamilton 《Journal of robotic surgery》2020,14(3):447-454
Partial nephrectomy is the mainstay of treatment for localized kidney cancer. A proportion of patients are upstaged post-operatively to locally advanced di 相似文献
7.
Virendra N Sehgal Ananta Khurana Vibhu Mendiratta Deepti Saxena Govind Srivastava Ashok K Aggarwal 《Indian journal of dermatology》2015,60(4):327-331
Atopic dermatitis is a well-recognized clinical entity, several facets of which continue to be mystified. Accordingly, its etio-pathogenesis is largely elusive. It appears to be an outcome of interplay of several undertones, namely: genetics, maternal factor and inheritance, pregnancy/intrauterine, environmental factors, immune dysregulation, immuno-globulins, role of diet, and infection. Besides, recent innovative breakthroughs consisting of nutritional supplementation, the highlights of which were considered worthwhile to take stock of to define its current status. An endeavor to enlighten the audience has been made for their benefit. 相似文献
8.
Sameer Arora Kamal Shemisa Muthiah Vaduganathan Arman Qamar Ankur Gupta Sushil K. Garg Dharam J. Kumbhani Helen Mayo Houman Khalili Ambarish Pandey Sandeep R. Das 《Journal of the American College of Cardiology》2019,73(19):2454-2464
Ticagrelor is a cornerstone of modern antithrombotic therapy alongside aspirin in patients with acute coronary syndrome and after percutaneous coronary intervention. Adverse effects such as bleeding and dyspnea have been associated with premature ticagrelor discontinuation, which may limit any potential advantage of ticagrelor over clopidogrel. The randomized trials of ticagrelor captured adverse events, offering the opportunity to more precisely quantify these effects across studies. Therefore, a meta-analysis of 4 randomized clinical trials of ticagrelor conducted between January 2007 and June 2017 was performed to quantify the incidence and causes of premature ticagrelor discontinuation. Among 66,870 patients followed for a median 18 months, premature ticagrelor discontinuation was seen in 25%; bleeding was the most common cause of discontinuation followed by dyspnea. Versus the comparators, the relative risk of dyspnea-related discontinuation during follow-up was 6.4-fold higher, the relative risk of bleeding was 3.2-fold higher, and the relative risk of discontinuation due to any adverse event was 59% higher for patients receiving ticagrelor. Understanding these potential barriers to adherence to ticagrelor is crucial for informed patient-physician decision making and can inform future efforts to improve ticagrelor adherence. This review discusses the incidence, causes, and biological mechanisms of ticagrelor-related adverse effects and offers strategies to improve adherence to ticagrelor. 相似文献
9.
Caleb Miller Syed J. Raza Facundo Davaro Allison May Sameer Siddiqui Zachary A. Hamilton 《Journal of Geriatric Oncology》2019,10(2):285-291
Objective
Treatment of renal cell carcinoma has evolved with emphasis on nephron preservation for small renal masses. Our objective was to evaluate the proportions of treatment types for octogenarians with clinical stage 1 renal cell carcinoma.Materials and Methods
The National Cancer Database was analyzed from 2004 to 2015. Patients with clinical stage 1, tumor size?≤?7?cm, and age 80–89?years old were compared to a younger control arm of patients?≤?70?years old. Treatment modality was categorized as radical nephrectomy (RN), partial nephrectomy (PN), percutaneous ablative therapy (PAT), and no treatment (NT). Primary outcome was treatment utilization over time using estimated annual percentage change (EAPC). Secondary outcomes included logistic regression for 30?day readmission after treatment and any definitive tumor treatment choice.Results
18,903 octogenarians were identified and compared to a control of 142,179 patients?≤?70?years old. Overall, NT (36%) was the most common modality for octogenarians while PN (44.8%) was most common for the control arm. Using EAPC for octogenarians, we found increases for PAT (7.1%), PN (2.8%), and NT (1.6%) but a decrease for RN (?4.6%). EAPC for the younger cohort noted increases for PAT (6.8%), PN (5.4%), and NT (4.4%) but a decrease for RN (?5.5%).Conclusion
For octogenarians with stage 1 renal cell carcinoma, minimally invasive treatments are increasingly utilized, while RN is decreasing. Compared to a younger cohort, a greater proportion of octogenarians are receiving NT. These findings remain encouraging for appropriate treatment of localized disease in patients with advanced age. 相似文献10.
Pathogenic variants in the SCN2A gene are associated with a variety of neurodevelopmental phenotypes, defined in recent years through multicenter collaboration. Phenotypes include benign (self‐limited) neonatal and infantile epilepsy and more severe developmental and epileptic encephalopathies also presenting in early infancy. There is increasing evidence that an important phenotype linked to the gene is autism and intellectual disability without epilepsy or with rare seizures in later childhood. Other associations of SCN2A include the movement disorders chorea and episodic ataxia. It is likely that as genetic testing enters mainstream practice that new phenotypic associations will be identified. Some missense, gain of function variants tend to present in early infancy with epilepsy, whereas other missense or truncating, loss of function variants present with later‐onset epilepsies or intellectual disability only. Knowledge of both mutation type and functional consequences can guide precision therapy. Sodium channel blockers may be effective antiepileptic medications in gain of function, neonatal and infantile presentations. 相似文献