全文获取类型
收费全文 | 2815篇 |
免费 | 121篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 195篇 |
妇产科学 | 63篇 |
基础医学 | 191篇 |
口腔科学 | 190篇 |
临床医学 | 231篇 |
内科学 | 556篇 |
皮肤病学 | 47篇 |
神经病学 | 267篇 |
特种医学 | 59篇 |
外科学 | 570篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 59篇 |
眼科学 | 199篇 |
药学 | 190篇 |
中国医学 | 1篇 |
肿瘤学 | 70篇 |
出版年
2024年 | 1篇 |
2023年 | 12篇 |
2022年 | 17篇 |
2021年 | 55篇 |
2020年 | 48篇 |
2019年 | 61篇 |
2018年 | 83篇 |
2017年 | 60篇 |
2016年 | 75篇 |
2015年 | 92篇 |
2014年 | 116篇 |
2013年 | 155篇 |
2012年 | 189篇 |
2011年 | 175篇 |
2010年 | 101篇 |
2009年 | 101篇 |
2008年 | 200篇 |
2007年 | 245篇 |
2006年 | 203篇 |
2005年 | 237篇 |
2004年 | 196篇 |
2003年 | 147篇 |
2002年 | 131篇 |
2001年 | 60篇 |
2000年 | 43篇 |
1999年 | 31篇 |
1998年 | 10篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1995年 | 13篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 14篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1970年 | 1篇 |
1966年 | 2篇 |
1965年 | 1篇 |
排序方式: 共有2951条查询结果,搜索用时 15 毫秒
1.
Laura A. Huppert MD Ozge Gumusay MD Dame Idossa MD Hope S. Rugo MD 《CA: a cancer journal for clinicians》2023,73(5):480-515
Hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer is defined by the presence of the estrogen receptor and/or the progesterone receptor and the absence of HER2 gene amplification. HR-positive/HER2-negative breast cancer accounts for 65%–70% of all breast cancers, and incidence increases with increasing age. Treatment varies by stage, and endocrine therapy is the mainstay of treatment in both early stage and late-stage disease. Combinations with cyclin-dependent kinase 4/6 inhibitors have reduced distant recurrence in the early stage setting and improved overall survival in the metastatic setting. Chemotherapy is used based on stage and tumor biology in the early stage setting and after endocrine resistance for advanced disease. New therapies, including novel endocrine agents and antibody-drug conjugates, are now changing the treatment landscape. With the availability of new treatment options, it is important to define the optimal sequence of treatment to maximize clinical benefit while minimizing toxicity. In this review, the authors first discuss the pathologic and molecular features of HR-positive/HER2-negative breast cancer and mechanisms of endocrine resistance. Then, they discuss current and emerging therapies for both early stage and metastatic HR-positive/HER2-negative breast cancer, including treatment algorithms based on current data. 相似文献
2.
3.
4.
5.
6.
The Effects of Successful Percutaneous Mitral Balloon Valvuloplasty on Acute and Intermediate Term Aortic Stiffness 下载免费PDF全文
7.
8.
Emire Seyahi Osman Serdal Cakmak Burcin Tutar Caner Arslan Atilla Suleyman Dikici Necdet Sut Fatih Kantarci Hasan Tuzun Melike Melikoglu Hasan Yazici 《Medicine》2015,94(44)
Vascular involvement can be seen in up to 40% of patients with Behcet syndrome (BS), the lower-extremity vein thrombosis (LEVT) being the most common type. The aim of the current study was to compare venous Doppler findings and clinical features between BS patients with LEVT and control patients diagnosed as having LEVT due to other causes.All consecutive 78 patients (71 men, 7 women; mean age 38.6 ± 10.3 years) with LEVT due to BS and 50 control patients (29 men, 21 women; mean age 42.0 ± 12.5 years) who had LEVT due to other causes, or idiopathic, were studied with the help of a Doppler ultrasonography after a detailed clinical examination. Patterns of venous disease were identified by cluster analyses. Clinical features of chronic venous disease were assessed using 2 classification systems. Venous claudication was also assessed.Patients with BS were more likely to be men, had significantly earlier age of onset of thrombosis, and were treated mainly with immunosuppressives and less frequently with anticoagulants. Furthermore, they had significantly more bilateral involvement, less complete recanalization, and more frequent collateral formation. While control patients had a disorganized pattern of venous involvement, BS patients had a contiguous and symmetric pattern, involving all deep and superficial veins of the lower extremities, with less affinity for crural veins. Clinical assessment, as measured by the 2 classification systems, also indicated a more severe disease among the BS patients. In line, 51% of the BS patients suffered from severe post-thrombotic syndrome (PTS) and 32% from venous claudication, whereas these were present in 8% and 12%, respectively, among the controls. Among BS patients, a longer duration of thrombosis, bilateral femoral vein involvement, and using no anticoagulation along with immunosuppressive treatment when first diagnosed were found to be associated independently with severe PTS.Lower-extremity vein thrombosis associated with BS, when compared to LEVT due to other causes, had distinctive demographic and ultrasonographic characteristics, and had clinically a more severe disease course. 相似文献
9.
Hasan Demirci PhD Hacer Durmus MD Guven Toksoy PhD Atilla Uslu PhD Yesim Parman MD Hasmet Hanagasi MD 《Muscle & nerve》2020,62(6):710-716
Duchenne muscular dystrophy (DMD) has been found to be associated with cognitive impairment. However, few studies have addressed cognitive impairment among mothers of children with DMD. In the present study, the neuropsychological profiles of both carrier mothers (C-Ms) and noncarrier mothers (NC-Ms) were examined, and the findings were compared with healthy control mothers (HC-Ms). There were 90 participants, consisting of 31 C-Ms, 24 NC-Ms, and 35 HC-Ms, each of whom completed a neuropsychological test battery. C-Ms had poorer cognition performance in attention, working memory, immediate verbal memory, visuospatial skills, and executive functions than NC-Ms, and HC-Ms. This study provides evidence that there may be cognitive impairment in mothers of patients with DMD. The cognitive impairment of C-Ms has similarities to that seen in children with DMD. 相似文献
10.
Giray Bozkaya Ozge Fenercioglu İsmail Demir Aslı Guler Behnaz Aslanipour 《Gynecological endocrinology》2020,36(10):849-853
AbstractNeudesin is a neuropeptide hormone involves in female reproduction system via promoting effects of progesterone. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder associated with hypothalamic-pituitary-ovarian axis abnormalities and impaired negative feedback mechanism of progesterone upon gonadotropin-releasing hormone secretion. Our aims were to discover whether neudesin levels were altered in PCOS women comparing to controls and to determine the link of neudesin with hormonal-metabolic parameters in PCOS women. The current research was designed as a case-control study. Sixty-eight subjects with PCOS and 67 age- and body mass index (BMI)-matched subjects as controls were enrolled into the study. Circulating neudesin levels were measured by ELISA. Neudesin levels were significantly lower in PCOS subjects compared to controls (4.07?±?1.22 vs. 6.02?±?2.07?ng/ml, p?<?.001). Neudesin exhibited an inversely independent link with luteinizing hormone, free-androgen index, and BMI whereas it showed a positively independent link with progesterone in women with PCOS. Logistic regression analysis revealed that decreased neudesin levels were parallel with increased risk of having PCOS. Decreased neudesin levels were associated with hormonal disturbances in PCOS women, suggesting that neudesin may play a role in pathophysiology of PCOS. 相似文献