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Tobin Nicolas Good Bryan C. Plasencia Jonathan D. Fogel Mark A. Weiss William J. Manning Keefe B. 《Annals of biomedical engineering》2022,50(8):929-940
Annals of Biomedical Engineering - Patients with Fontan circulation have increased risk of heart failure, but are not always candidates for heart transplant, leading to the development of the... 相似文献
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Flavien Rouxel Raissa Relator Jennifer Kerkhof Haley McConkey Michael Levy Patricia Dias Mouna Barat-Houari Nathalie Bednarek Odile Boute Nicolas Chatron Florian Cherik Andrée Delahaye-Duriez Martine Doco-Fenzy Laurence Faivre Lucas W. Gauthier Delphine Heron Michael S. Hildebrand Gaëtan Lesca David Genevieve 《Genetics in medicine》2022,24(5):1096-1107
PurposeRare genetic variants in CDK13 are responsible for CDK13-related disorder (CDK13-RD), with main clinical features being developmental delay or intellectual disability, facial features, behavioral problems, congenital heart defect, and seizures. In this paper, we report 18 novel individuals with CDK13-RD and provide characterization of genome-wide DNA methylation.MethodsWe obtained clinical phenotype and neuropsychological data for 18 and 10 individuals, respectively, and compared this series with the literature. We also compared peripheral blood DNA methylation profiles in individuals with CDK13-RD, controls, and other neurodevelopmental disorders episignatures. Finally, we developed a support vector machine–based classifier distinguishing CDK13-RD and non–CDK13-RD samples.ResultsWe reported health and developmental parameters, clinical data, and neuropsychological profile of individuals with CDK13-RD. Genome-wide differential methylation analysis revealed a global hypomethylated profile in individuals with CDK13-RD in a highly sensitive and specific model that could aid in reclassifying variants of uncertain significance.ConclusionWe describe the novel features such as anxiety disorder, cryptorchidism, and disrupted sleep in CDK13-RD. We define a CDK13-RD DNA methylation episignature as a diagnostic tool and a defining functional feature of the evolving clinical presentation of this disorder. We also show overlap of the CDK13 DNA methylation profile in an individual with a functionally and clinically related CCNK-related disorder. 相似文献
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Lira-Nogueira M. C. B. Gibson V. P. Nicolas V. Santos-Magalhães N. S. Vauthier C. 《Pharmaceutical research》2022,39(6):1135-1150
Pharmaceutical Research - This work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface composition and architecture, assuming... 相似文献
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Lombardo Joseph Ko Kevin Shimada Ayako Nelson Nicolas Wright Christopher Chen Jerry Maity Alisha Ruggiero Marissa L. Richard Scott Papanagnou Dimitrios Mitchell Edith Leader Amy Simone Nicole L. 《Cancer causes & control : CCC》2022,33(4):559-582
Cancer Causes & Control - A disparity exists in cancer screening rates for the Sexual and Gender Minority (SGM) community. We sought to understand the perceptions and baseline knowledge of... 相似文献
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Paula Rios Helen D. Bailey Claire Poulalhon Dominique Valteau-Couanet Gudrun Schleiermacher Christophe Bergeron Arnaud Petit Anne-Sophie Defachelles Gambart Marion Nicolas Sirvent Stéphane Ducassou Caroline Munzer Laurent Orsi Brigitte Lacour Jacqueline Clavel 《International journal of cancer. Journal international du cancer》2019,145(11):2907-2916
Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case–control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life-style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. A meta-analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1%) than for the controls (19.7%) (OR 1.3 [95% CI 0.9–1.7]; summary OR from meta-analysis 1.1 [95% CI 1.0–1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95% CI 0.9–1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95% CI 1.1–2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95% CI 0.8–1.4], summary OR from meta-analysis 1.0 [95% CI 0.9–1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy. 相似文献
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Manuela Tutolo Jean‐Nicolas Cornu Ricarda M. Bauer Sascha Ahyai Giorgio Bozzini John Heesakkers Marcus J. Drake Kari A.O. Tikkinen Ene Launonen Stphane Larr Nikesh Thiruchelvam Richard Lee Philip Li Michele Favro Emanuele Zaffuto Alexander Bachmann Juan I. Martinez‐Salamanca Thomas Pichon Cosimo De Nunzio Enrico Ammirati Francois Haab Frank Van Der Aa 《Neurourology and urodynamics》2019,38(2):710-718