收费全文 | 6623篇 |
免费 | 366篇 |
国内免费 | 12篇 |
耳鼻咽喉 | 55篇 |
儿科学 | 422篇 |
妇产科学 | 113篇 |
基础医学 | 578篇 |
口腔科学 | 222篇 |
临床医学 | 422篇 |
内科学 | 1448篇 |
皮肤病学 | 288篇 |
神经病学 | 490篇 |
特种医学 | 160篇 |
外科学 | 974篇 |
综合类 | 199篇 |
一般理论 | 1篇 |
预防医学 | 318篇 |
眼科学 | 326篇 |
药学 | 592篇 |
中国医学 | 19篇 |
肿瘤学 | 374篇 |
2023年 | 46篇 |
2022年 | 34篇 |
2021年 | 198篇 |
2020年 | 114篇 |
2019年 | 204篇 |
2018年 | 255篇 |
2017年 | 187篇 |
2016年 | 224篇 |
2015年 | 223篇 |
2014年 | 323篇 |
2013年 | 339篇 |
2012年 | 555篇 |
2011年 | 621篇 |
2010年 | 326篇 |
2009年 | 241篇 |
2008年 | 362篇 |
2007年 | 372篇 |
2006年 | 296篇 |
2005年 | 273篇 |
2004年 | 240篇 |
2003年 | 188篇 |
2002年 | 189篇 |
2001年 | 110篇 |
2000年 | 118篇 |
1999年 | 92篇 |
1998年 | 46篇 |
1997年 | 21篇 |
1996年 | 19篇 |
1995年 | 39篇 |
1994年 | 18篇 |
1992年 | 70篇 |
1991年 | 67篇 |
1990年 | 42篇 |
1989年 | 38篇 |
1988年 | 54篇 |
1987年 | 39篇 |
1986年 | 32篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 23篇 |
1979年 | 22篇 |
1977年 | 16篇 |
1975年 | 16篇 |
1974年 | 26篇 |
1973年 | 15篇 |
1972年 | 27篇 |
1971年 | 19篇 |
1970年 | 15篇 |
1969年 | 16篇 |
1968年 | 18篇 |
To find out the relative prevalence of fetal neural tube defect (NTD) and its outcome in terms of survival at birth and beyond 2 years of age.
MethodsA 10-year prospective (2008–2018) observational study was performed, which included all prenatally detected fetal NTD. Two-year follow-up was done in cases of pregnancies resulting in live birth, in terms of their survival, physical morbidity and developmental delay.
ResultsNTD was seen in 401/648 (62%) cases among the central nervous system malformations. More than half of the cases (54.1%) presented after 20 weeks of gestation, and 42.8% of the mothers were primiparous. Spina bifida was seen in 206 cases, anencephaly in 144, encephalocele in 43, whereas iniencephaly was seen in only eight cases. Associated anomalies were present in 51.2%. Only 19.0% cases were live-born, and merely 11% were alive beyond 2 years of age. Among types of spina bifida, lumbosacral meningomyocele was the most common (41.6%), whereas thoracic was the rarest (8.7%). After 2 years, physical disability was observed in more than half of the cases who survived.
ConclusionsNTD is one of the commonest malformations with high mortality, and the physical and mental sub-normality is high among those who survive.
相似文献Abbreviations
- 6MWD
- 6‐min walking distance
- ACEI
- ACE inhibitor
- ARB
- angiotensin receptor blocker
- BPS
- British Pharmacological Society
- CCB
- calcium channel blocker
- CKD
- chronic kidney disease
- Cmax
- maximum plasma/serum concentration
- CTEPH
- chronic thromboembolic pulmonary hypertension
- CVD
- cardiovascular disease
- CYP2C19
- cytochrome P450, family 2, subfamily C, polypeptide 19
- CYP2C9
- cytochrome P450, family 2, subfamily C, polypeptide 9
- CYP2D6
- cytochrome P450, family 2, subfamily D, polypeptide 6
- CYP3A
- cytochrome P450, family 3, subfamily A
- CYP3A4
- cytochrome P450, family 3, subfamily A, polypeptide 4
- CYP450
- cytochrome P450 enzyme family
- DN
- diabetic nephropathy
- ED
- erectile dysfunction
- eGFR
- estimated GFR
- ERA
- endothelin receptor antagonist
- ET
- endothelin
- ET‐1
- endothelin‐1
- FGR
- fetal growth restriction
- GSK3B
- glycogen synthase kinase 3 β
- HbA1c
- glycated Hb
- HFpEF
- heart failure with preserved ejection fraction
- HFrEF
- heart failure with reduced ejection fraction
- IC50
- half maximal inhibitory concentration
- IUPHAR
- International Union of Basic and Clinical Pharmacology
- MI
- myocardial infarction
- mitoKATP
- mitochondrial ATP‐sensitive potassium channels
- NAION
- nonarteritic anterior ischaemic optic neuropathy
- Na+/K+‐ATPase
- sodium–potassium pump
- NOS1
- neuronal NOS
- NOS2
- inducible NOS
- NOS3
- endothelial NOS
- PAH
- pulmonary arterial hypertension
- PDE5I
- PDE type 5 inhibitor
- PH
- pulmonary hypertension
- PPHN
- persistent pulmonary hypertension of the newborn
- RCT
- randomised controlled trial
- RHTN
- treatment‐resistant hypertension
- RP
- Raynaud''s phenomenon
- sGC
- soluble GC
- SGLT2
- sodium–glucose cotransporter 2
- Tmax
- time taken to reach the maximum plasma concentration
- T2DM
- type 2 diabetes mellitus
- UACR
- urinary albumin/creatinine ratio
- V/Q
- ventilation/perfusion