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Valentina Guercio Francesca Donato Claudio Pelucchi Federica Verga Valter Passini Carlotta Galeone Eva Negri Giacomo Garzaro Paolo Boffetta Carlo La Vecchia Alessandra Tavani Enrico Pira 《La Medicina del lavoro》2019,110(5):342
Background::Soft tissue sarcoma (STS) is a heterogeneous group of rare neoplasms whose aetiology is largely unknown. Dioxin and dioxin-like compounds, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and polychlorinated biphenyls (PCBs), are potential risk factors for STS.Objectives:To investigate the relation of 17 PCBs congeners, assessed in human plasma, with STS risk.Methods:We conducted a case-control study in Italy, including 52 STS cases and 99 hospital-based controls. Selected PCB were extracted by high-performance liquid chromatography (HPLC) and measured with gas chromatography-mass spectrometry (GC-MS). Odds ratios (OR), and the corresponding 95% confidence intervals (CI), were estimated through multivariate logistic regression models.Results:The most frequently detected PCB congeners were 138, 170, 180 and 149 (detected in 40-77% of controls). The OR for the sum of all 17 PCB congeners was 1.20 (95% CI 0.50-2.92). In categorical analysis no consistent association was found for individual congeners and for groups based on Wolff’s classification or the degree of chlorination. For continuous estimates, borderline positive associations emerged for Wolff’s groups 2A (OR 1.23, 95% CI 0.97-1.55), 2B (OR 1.34, 95% CI 1.00-1.77, and 3 (OR 1.19, 95% CI 0.96-1.49), for moderately (OR 1.20, 95% CI 0.96-1.51) and highly (OR 1.18, 95% CI 0.99-1.41) chlorinated PCBs, and for congeners 170 (OR 1.26, 95% CI 0.98-1.63), 180 (OR 1.26, 95% CI 0.97-1.64) and 138 (OR 1.45, 95% CI 1.02-2.04).Discussion:Most associations between PCBs and STS risk were not significant, but, given the limited sample size, we cannot exclude moderate associations.Key words: Soft tissue sarcoma, polychlorinated biphenyls, epidemiology, environmental risk factors, chemical contaminants, case-control study 相似文献
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Manuela Tutolo Jean‐Nicolas Cornu Ricarda M. Bauer Sascha Ahyai Giorgio Bozzini John Heesakkers Marcus J. Drake Kari A.O. Tikkinen Ene Launonen Stphane Larr Nikesh Thiruchelvam Richard Lee Philip Li Michele Favro Emanuele Zaffuto Alexander Bachmann Juan I. Martinez‐Salamanca Thomas Pichon Cosimo De Nunzio Enrico Ammirati Francois Haab Frank Van Der Aa 《Neurourology and urodynamics》2019,38(2):710-718
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Paolo Schiavi Francesco Pogliacomi Massimiliano Colombo Andrea Amarossi Francesco Ceccarelli Enrico Vaienti 《Injury》2019,50(2):420-423
Introduction
Femoral neck fractures are the most frequent fractures in the elderly and hemiarthroplasty is the treatment of choice. The objective of this multicenter study is to identify predictive factors of acetabular erosion after bipolar hemiarthroplasty (surgery between 1997 and 2007) in a mobile independent population during a follow-up of ten years.Materials and methods
Data were prospectively collected and retrospectively analyzed. Inclusion criteria were: age >60 and <85 years, BMI?<?35, normal Abbreviated MiniMental Test score, ability to walk 0.8?km and live independently, non-pathological fracture, hip with no or minimal osteoarthritic changes, and availability of clinical and radiological follow-up. For each Patient were recorded: demographic data, comorbidities, time from fracture to surgery, characteristics of the implant, duration of surgery. Patients included underwent clinical and radiological follow-up.Results
Overall, 209 Patients met inclusion criteria. A press-fit implant was performed in 172 subjects; in contrast a cemented prosthesis was implanted in 37 patients. Nineteen patients underwent implant revision to total hip arthroplasty for acetabular erosion and pain. Classification of X-ray using Baker criteria showed a grade 0 in 54.5%, a grade 1 in 19.6%, a grade 2 in 18.1% and a grade 3 in 7.6%. Multivariate analysis revealed that the size of the femoral head (FH) was the only predictive factor of a higher risk of acetabular erosion. The Kaplan-Meier survival curve verified the risk of implant revision in Group 1 (FH sized >48?mm) and Group 2 (FH sized <48?mm). The probability of implant revision for acetabular erosion at ten years from surgery were 5.5% in Group 1 and 15.6% in Group 2.Conclusion
In bipolar hemiarthroplasty smaller head size lead to a polar wear implying a higher risk of acetabular erosion and migration; in our population this risk was consistent with the use of implant head <48?mm diameter. Considering the absolute risk of a smaller FH size, the surgeon must evaluate the accuracy of measurement of the caliber, since the size can be significantly underestimated. 相似文献6.
Paolo Ceccarini Giuseppe Rinonapoli Enrico Sebastiani Michele Bisaccia Alfredo Ceccarini Auro Caraffa 《The Journal of foot and ankle surgery》2019,58(2):221-225
The treatment of hammer toe has been advocated for years, and many procedures have been proposed with skeletal and soft tissue intervention. The purpose of the present study was to compare arthrodesis of the proximal interphalangeal joint with shortening osteotomy of the proximal phalanx neck. In most cases, both procedures have been associated with elongation of the extensor apparatus, capsulotomy of the metatarsophalangeal joint, and stabilization with a Kirschner wire. To experiment with a technique that respects the anatomy and joint function, we used a distal subtraction osteotomy of the proximal phalanx neck. We compared a series of 78 patients, divided in to 2 groups: 38 (48.7%) treated with arthrodesis and 40 (51.3%) with shortening osteotomy. Patients were aged 22 to 78 years, with a mean final follow-up period of 56.6 (range 24 to 96) months. For clinical evaluation, we used the American Orthopaedic Foot and Ankle Society score, Foot and Ankle Outcome Score, and a subjective rating scale. The results were comparable between the 2 techniques; however, we report faster functional recovery in the group treated with shortening osteotomy (p < .0001), with an adjunctive advantage of preserving the integrity of the proximal interphalangeal joint. Thus, according to our results, this technique is comparable to arthrodesis. 相似文献
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Enrico Piccinelli Mireya Beatriz Castro-Verdes Alain Fraisse Carles Bautista-Rodriguez 《Journal of cardiac failure》2021,27(3):364-367
BackgroundBalloon dilation and stenting of the atrial septum are techniques used to unload left heart cavities in acute or end-stage heart failure in children. However, they carry significant risks such as tamponade or device embolization.Case PresentationWe report the first case of a child with an end-stage mitochondrial cardiomyopathy on a venoarterial extracorporeal membrane oxygenator as a bridge to heart transplant where an atrial flow regulator device has been implanted.ConclusionsThis case illustrates the feasibility and safety of atrial flow regulator implantation in this setting. This procedure allowed to wean inotropic support while awaiting heart transplantation. 相似文献
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