全文获取类型
收费全文 | 774篇 |
免费 | 46篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 14篇 |
妇产科学 | 9篇 |
基础医学 | 133篇 |
口腔科学 | 19篇 |
临床医学 | 64篇 |
内科学 | 164篇 |
皮肤病学 | 3篇 |
神经病学 | 199篇 |
特种医学 | 13篇 |
外科学 | 45篇 |
综合类 | 1篇 |
预防医学 | 30篇 |
眼科学 | 18篇 |
药学 | 82篇 |
肿瘤学 | 31篇 |
出版年
2023年 | 2篇 |
2021年 | 18篇 |
2020年 | 6篇 |
2019年 | 19篇 |
2018年 | 35篇 |
2017年 | 30篇 |
2016年 | 24篇 |
2015年 | 22篇 |
2014年 | 33篇 |
2013年 | 30篇 |
2012年 | 50篇 |
2011年 | 66篇 |
2010年 | 40篇 |
2009年 | 29篇 |
2008年 | 46篇 |
2007年 | 50篇 |
2006年 | 32篇 |
2005年 | 47篇 |
2004年 | 30篇 |
2003年 | 28篇 |
2002年 | 35篇 |
2001年 | 7篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 5篇 |
1993年 | 6篇 |
1992年 | 9篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1975年 | 2篇 |
1970年 | 2篇 |
1957年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有827条查询结果,搜索用时 17 毫秒
1.
2.
3.
Joseph S. Fernandez‐Moure Jeffrey L. Van Eps Jacob C. Scherba Iman K. Yazdi Andrew Robbins Fernando Cabrera Cory J. Vatsaas Michael Moreno Bradley K. Weiner Ennio Tasciotti 《Journal of tissue engineering and regenerative medicine》2021,15(1):3-13
The recurrence of ventral hernias continues to be a problem faced by surgeons, in spite of efforts toward implementing novel repair techniques and utilizing different materials to promote healing. Cadaveric acellular dermal matrices (Alloderm) have shown some promise in numerous surgical subspecialties, but these meshes still suffer from subsequent failure and necessitation of re‐intervention. Here, it is demonstrated that the addition of platelet rich plasma to Alloderm meshes temporally modulates both the innate and cytotoxic inflammatory responses to the implanted material. This results in decreased inflammatory cytokine production at early time points, decreased matrix metalloproteinase expression, and decreased CD8+ T cell infiltration. Collectively, these immune effects result in a healing phenotype that is free from mesh thinning and characterized by increased material stiffness. 相似文献
4.
Latent tuberculosis infection detection and active tuberculosis prevention in patients receiving anti‐TNF therapy: an Italian nationwide survey 下载免费PDF全文
5.
Margherita Russo Carmela Rifici Edoardo Sessa Giangaetano D’Aleo Placido Bramanti Rocco Salvatore Calabrò 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2015,23(1)
Nabiximols (Sativex) is an oromucosal spray, containing delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD), used as treatment for unresponsive spasticity in multiple sclerosis (MS) patients. Sativex is thought to not affect cognition or induce any psychiatric problem at the doses generally used. Nonetheless, it is known that the concomitant use of more than one muscle-relaxant drugs can result in additive neuropsychiatric effects. Herein we describe a case of a woman affected by MS and treated with baclofen and methylprednisolone, who developed important behavioral changes, including suicidal ideation, after 4 weeks of Sativex administration. We are not completely able to state if Sativex alone was responsible for our patient’s psychiatric symptoms, in reason of the concomitant use of the other drugs.In conclusion, physicians should pay more attention when prescribing drugs to MS patients affected by spasticity, including Sativex, since neurobehavioral side effects may emerge especially in predisposed individuals. 相似文献
6.
Agnese Gugliandolo Sabrina Giacoppo Placido Bramanti Emanuela Mazzon 《Inflammation》2018,41(1):93-103
Amyotrophic lateral sclerosis (ALS) is a disabling progressive disease characterized by the degeneration of motor neurons, leading to muscle atrophy and paralysis. The majority of cases are sporadic, but also a familiar form of ALS exists, and some genes causative of the pathology were found. In particular, mutations in superoxide dismutase 1 (SOD1) were found in 20% of familiar cases. It is known that neuroinflammation plays a pivotal role in several neurodegenerative disorders, including ALS. Inflammasomes are protein complexes that induce inflammation in response to various stimuli, involved also in neuroinflammation. The NLRP3 inflammasome, which is the best known, after assembly, induces the activation of caspase 1, which in turn activates interleukin (IL)-1β and IL-18. The aim of this work was the evaluation of inflammasome activation in the brain of SOD1G93A rats, a transgenic model of ALS. We observed the increase in TLR4 and nuclear NF-κB levels in SOD1G93A rats. Their activation is known as priming signal for inflammasome induction. Moreover, NLRP3 protein increased, associated with the presence of active caspase 1, leading to an increase in IL-18 and IL-1β levels. In addition, IL-1β, IL-18, and IFN-γ amount increased in the spleen of SOD1G93A rats, together with an increased expression of CD4, CD8, CD44, and CD68 markers. In conclusion, our results showed the activation of the NLRP3 inflammasome in the brain of SOD1G93A rats, indicating that inflammation plays a main role in ALS. 相似文献
7.
Antonio Miadonna Alberto Tedeschi Ennio Leggieri Marco Froldi Carlo Zanussi 《International Journal of Clinical & Laboratory Research》1983,13(2):235-245
Summary The specific IgE response that appears in subjects immunized with tetanus toxoid does not induce hypersensitivity reactions
at subsequent immunizations. The type I immune response, therefore, was studied bothin vivo andin vitro, in 11 subjects who had specific IgE antibodies for tetanus toxoid. The results showed that: 1. the specific IgE antibodies
are heterogeneous regarding their affinity for the mast cell and basophil receptors; 2. the specific IgG antibodies for tetanus
toxoid, at serum concentrations, are not able to interfere with thein vitro specific basophil degranulation; 3. in the PEG precipitare there are aggregates of specific IgE antibodies for tetanus toxoid.In vitro, these molecular aggregates are not able to sensitize the basophil cells. 相似文献
8.
Cuzzocrea S Di Paola R Genovese T Mazzon E Esposito E Crisafulli C Bramanti P Salvemini D 《The Journal of pharmacology and experimental therapeutics》2008,327(1):45-57
Ceramide is a sphingolipid with potent proinflammatory and proapoptotic properties. This study sought to determine whether pharmacological inhibition of ceramide biosynthesis in the intestine attenuates pathophysiological sequelae of shock induced by splanchnic artery occlusion and reperfusion. Ischemia and reperfusion injury was induced in anesthetized rats by clamping both the superior mesenteric artery and the celiac artery for 45 min followed by reperfusion. Within 6 min after reperfusion, animals developed significant systemic hypotension with 100% of the animals dying during the 4-h period of reperfusion. In parallel experiments, animals were necropsied after 60 min of reperfusion, and the ileum was harvested for histological examination and assessment of biochemical changes. Administration of fumonisin B1 (FB1), a competitive and reversible inhibitor of ceramide synthase (3 mg/kg, 15 min before reperfusion), significantly reduced i) the increased ceramide expression as detected by immunohistochemistry; ii) peroxynitrite-mediated protein nitration; iii) infiltration of the reperfused intestine with polymorphonuclear neutrophils following a decrease in intercellular adhesion molecule-1 expression; iv) production of the proinflammatory cytokine tumor necrosis factor-alpha; and v) apoptosis in the ileum. Overall, tissue-protective effects were clearly observed upon histological examination of the ileum. These beneficial events were ultimately linked to decreases in both the development of hypotension and overall mortality. These results implicate ceramide as a key signaling molecule in splanchnic arterial ischemia and reperfusion-induced shock. The broader implications of our results provide a pharmacological rationale for the development of inhibitors of ceramide biosynthesis as novel therapeutics for ischemia and reperfusion-induced shock of several etiologies. 相似文献
9.
10.
Effects of bergamot essential oil and its extractive fractions on SH‐SY5Y human neuroblastoma cell growth 下载免费PDF全文