全文获取类型
收费全文 | 11184篇 |
免费 | 687篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 185篇 |
儿科学 | 531篇 |
妇产科学 | 262篇 |
基础医学 | 1241篇 |
口腔科学 | 504篇 |
临床医学 | 762篇 |
内科学 | 3021篇 |
皮肤病学 | 225篇 |
神经病学 | 761篇 |
特种医学 | 418篇 |
外科学 | 1464篇 |
综合类 | 102篇 |
一般理论 | 4篇 |
预防医学 | 678篇 |
眼科学 | 231篇 |
药学 | 829篇 |
中国医学 | 60篇 |
肿瘤学 | 640篇 |
出版年
2023年 | 80篇 |
2022年 | 76篇 |
2021年 | 309篇 |
2020年 | 243篇 |
2019年 | 374篇 |
2018年 | 486篇 |
2017年 | 296篇 |
2016年 | 384篇 |
2015年 | 376篇 |
2014年 | 516篇 |
2013年 | 602篇 |
2012年 | 868篇 |
2011年 | 880篇 |
2010年 | 501篇 |
2009年 | 421篇 |
2008年 | 667篇 |
2007年 | 674篇 |
2006年 | 585篇 |
2005年 | 486篇 |
2004年 | 465篇 |
2003年 | 406篇 |
2002年 | 349篇 |
2001年 | 213篇 |
2000年 | 189篇 |
1999年 | 188篇 |
1998年 | 81篇 |
1997年 | 68篇 |
1996年 | 49篇 |
1995年 | 51篇 |
1994年 | 45篇 |
1993年 | 33篇 |
1992年 | 86篇 |
1991年 | 87篇 |
1990年 | 83篇 |
1989年 | 48篇 |
1988年 | 43篇 |
1987年 | 60篇 |
1986年 | 50篇 |
1985年 | 57篇 |
1984年 | 40篇 |
1983年 | 35篇 |
1981年 | 22篇 |
1980年 | 22篇 |
1979年 | 39篇 |
1978年 | 22篇 |
1977年 | 20篇 |
1975年 | 24篇 |
1974年 | 27篇 |
1973年 | 28篇 |
1969年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Silvia Radenkovic Diego Martinelli Yuebo Zhang Graeme J. Preston Arianna Maiorana Alessandra Terracciano Maria Lisa Dentici Elisa Pisaneschi Antonio Novelli Wasantha Ranatunga Anna N. Ligezka Bart Ghesquière David R. Deyle Tamas Kozicz Filippo Pinto e Vairo Peter Witters Eva Morava 《Genetics in medicine》2022,24(4):894-904
PurposeTRAPPC9 deficiency is an autosomal recessive disorder mainly associated with intellectual disability (ID), microcephaly, and obesity. Previously, TRAPPC9 deficiency has not been associated with biochemical abnormalities.MethodsExome sequencing was performed in 3 individuals with ID and dysmorphic features. N-Glycosylation analyses were performed in the patients’ blood samples to test for possible congenital disorder of glycosylation (CDG). TRAPPC9 gene, TRAPPC9 protein expression, and N-glycosylation markers were assessed in patient fibroblasts. Complementation with wild-type TRAPPC9 and immunofluorescence studies to assess TRAPPC9 expression and localization were performed. The metabolic consequences of TRAPPC9 deficiency were evaluated using tracer metabolomics.ResultsAll 3 patients carried biallelic missense variants in TRAPPC9 and presented with an N-glycosylation defect in blood, consistent with CDG type I. Extensive investigations in patient fibroblasts corroborated TRAPPC9 deficiency and an N-glycosylation defect. Tracer metabolomics revealed global metabolic changes with several affected glycosylation-related metabolites.ConclusionWe identified 3 TRAPPC9 deficient patients presenting with ID, dysmorphic features, and abnormal glycosylation. On the basis of our findings, we propose that TRAPPC9 deficiency could lead to a CDG (TRAPPC9-CDG). The finding of abnormal glycosylation in these patients is highly relevant for diagnosis, further elucidation of the pathophysiology, and management of the disease. 相似文献
2.
Paula Pessin Fábrega Branisso Claudia Pinto Marques Souza de Oliveira Hilton Muniz Leão Filho Fabiana Roberto Lima Aritânia Sousa Santos Marcio Correa Mancini Maria Edna de Melo Flair José Carrilho Manoel de Souza Rocha Paul Clark Henrique José Pereira Branisso Cintia Cercato 《Annals of hepatology》2022,27(4):100707
IntroductionAlthough hyperferritinemia may reflect the inflammatory status of patients with non-alcoholic fatty liver disease (NAFLD), approximately 33% of hyperferritinemia cases reflect real hepatic iron overload.AimTo evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.MethodsThis cross-sectional study assessed patients with biopsy-proven NAFLD. MRI relaxometry was performed using a 3T scanner in all patients, and the results were compared with iron content determined by liver biopsy. Ferritin, hepcidin, and ferritin subunits were assessed and classified according to ferritin levels and to siderosis identified by liver biopsy.ResultsA total of 67 patients with NAFLD were included in the study. MRI revealed mild iron overload in all patients (sensitivity, 73.5%; specificity, 70%). For mild (grade 1) siderosis, the transverse relaxation rate (R2*) threshold was 58.9 s?1 and the mean value was 72.5 s?1 (SD, 33.9), while for grades 2/3 it was 88.2 s?1 (SD, 31.9) (p < 0.001). The hepcidin threshold for siderosis was > 30.2 ng/mL (sensitivity, 87%; specificity, 82%). Ferritin H and ferritin L subunits were expressed similarly in patients with NAFLD, regardless of siderosis. There were no significant differences in laboratory test results between the groups, including glucose parameters and liver function tests.ConclusionsMRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome. 相似文献
3.
4.
Angele Martins Claudia Koch Mitali Joshi Roberta Pinto Paulo Passos 《Anatomical record (Hoboken, N.J. : 2007)》2021,304(10):2149-2182
5.
Sarvdeep Singh Dhatt Vishal Kumar Deepak Neradi Praveen Sodavarapu Tensubam Tomthin Meetei Vijay Goni 《Indian Journal of Orthopaedics》2021,55(4):1046
AimsTo evaluate vitamin D3 levels in patients who presented with increased musculo-skeletal pain after release of lockdown period when compared to pre-lockdown status.IntroductionDuring this COVID pandemic, many countries have implemented lockdown measures and people have to work from home and many students and workers have to restrict themselves to home. During this period, their outdoor activities were limited. After the partial release of this lockdown many of them started to have some kind of physical activity and started experiencing body pains. We evaluated such patients for vitamin D3 levels and symptoms of fibromyalgia.MethodsThis is a retrospective analysis of patients from age group 18–60 presented to outpatient department or on telephonic consultation after partial release of lockdown. All patients who had mild back ache before lockdown and had symptoms exaggerated during this lockdown release were included. All patients were investigated for vitamin D3, PTH, thyroid profile, liver functional and kidney functional tests.ResultsOut of 120 patients presented to us in a period of 3 months, 31 patients had increased symptoms when compared to pre-lockdown status. 20 out of 31 patients had low vitamin D3 levels. 14 patients also developed symptoms of fibromyalgia.ConclusionThere might be many reasons for increased pain during lockdown, but we focussed specially only on vitamin D3 because of its association with increased symptoms of COVID-19. This is a gentle reminder to test for vitamin D3 levels and supplement if found deficient.Supplementary InformationThe online version contains supplementary material available at 10.1007/s43465-021-00376-8. 相似文献
6.
7.
Swetlana Ladigan‐Badura Deepak B. Vangala Christoph Engel Karolin Bucksch Robert Hueneburg Claudia Perne Jacob Nattermann Verena Steinke‐Lange Nils Rahner Hans K. Schackert Jürgen Weitz Matthias Kloor Judith Kuhlkamp Huu Phuc Nguyen Gabriela Moeslein Christian Strassburg Monika Morak Elke Holinski‐Feder Reinhard Buettner Stefan Aretz Markus Loeffler Wolff Schmiegel Christian Pox Karsten Schulmann 《International journal of cancer. Journal international du cancer》2021,148(1):106-114
In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty‐nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early‐stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = .0231). Thirty‐two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28‐66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30. 相似文献
8.
9.
Nihar R. Desai Rolin L. Wade Pin Xiang Lionel Pinto Sasikiran Nunna Xin Wang Jason Exter Katherine E. Mues Mohdhar Habib ChiChang Chen 《Clinical cardiology》2021,44(5):715
BackgroundLow‐density lipoprotein cholesterol (LDL‐C) is a risk factor for atherosclerotic cardiovascular disease (ASCVD). There are limited real‐world data on LDL‐C lowering with evolocumab in United States clinical practice.HypothesisWe assessed LDL‐C lowering during 1 year of evolocumab therapy.MethodsThis retrospective cohort study used linked laboratory (Prognos) and medical claims (IQVIA Dx/LRx and PharMetrics Plus®) data. Patients with a first fill for evolocumab between 7/1/2015 and 10/31/2019 (index event) and LDL‐C ≥ 70 mg/dL were included (overall cohort; N = 5897). Additionally, a patient subgroup with a recent myocardial infarction (MI) within 12 months (median 130 days) before the first evolocumab fill was identified (N = 152). Reduction from baseline LDL‐C was calculated based on the lowest LDL‐C value recorded during a 12‐month follow‐up period.ResultsThe mean (SD) age was 65 (10) years; 61.9% of patients had ASCVD diagnoses and 70.7% of patients were in receipt of lipid‐lowering therapy. Following evolocumab treatment, changes in LDL‐C from baseline were −60% in the overall cohort (median [interquartile range (IQR)] 146 [115–180] mg/dL to 58 [36–84] mg/dL) and −65% in the recent MI subgroup (median [IQR] 137 [109–165] mg/dL to 48 [30–78] mg/dL). In the overall cohort and recent MI subgroup, 62.1% and 69.7% of patients achieved LDL‐C < 70 mg/dL, respectively.ConclusionsIn this real‐world analysis, evolocumab was associated with significant reductions in LDL‐C comparable to that seen in the FOURIER clinical trial, which were durable over 1 year of treatment. 相似文献
10.
Frequency and risk factors of narrow angles in patients with pseudoexfoliation: a case–control study
Al Owaifeer Adi Mohammed AlObaida Ibrahim Alzuhairy Sultan Raheman Syed J. Aljasim Leyla Edward Deepak P. 《International ophthalmology》2022,42(4):1085-1091
International Ophthalmology - To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients. A prospective case–control study was conducted during the... 相似文献