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1.
Nicholas B. Abt Lauren E. Miller Tara E. Mokhtari Derrick T. Lin Jeremy D. Richmon Daniel G. Deschler Mark A. Varvares Sidharth V. Puram 《American journal of otolaryngology》2021,42(6):103070
ObjectiveTo determine prognostic factors and survival patterns for different treatment modalities for nasal cavity (NC) and paranasal sinus (PS) mucosal melanoma (MM).MethodsPatients from 1973 to 2013 were analyzed using the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and multivariable cox proportional hazard modeling were used for survival analyses.ResultsOf 928 cases of mucosal melanoma (NC = 632, PS = 302), increasing age (Hazard Ratio [HR]:1.05/year, p < 0.001), T4 tumors (HR: 1.81, p = 0.02), N1 status (HR: 6.61, p < 0.001), and PS disease (HR: 1.50, p < 0.001) were associated with worse survival. Median survival length was lower for PS versus NC (16 versus 26 months, p < 0.001). Surgery and surgery + radiation therapy (RT) improved survival over non-treatment or RT alone (p < 0.001). Adding RT to surgery did not yield a survival difference compared with surgery alone (p = 0.43). Five-year survival rates for surgery and surgery + RT were similar, at 27.7% and 25.1% (p = 0.43).ConclusionSurgery increased survival significantly over RT alone. RT following surgical resection did not improve survival. 相似文献
2.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
3.
European Journal of Epidemiology - With the rising use of machine learning for healthcare applications, practitioners are increasingly confronted with the limitations of prediction models that are... 相似文献
4.
Scott R. Bauer MD ScM Peggy M. Cawthon PhD MPH Kristine E. Ensrud MD Anne M. Suskind MD MS John C. Newman MD PhD Howard A. Fink MD MPH Kaiwei Lu MS Rebecca Scherzer PhD Andrew R. Hoffman MD Kenneth Covinsky MD Lynn M. Marshall ScD For the Osteoporotic Fractures in Men Research Group 《Journal of the American Geriatrics Society》2022,70(4):1082-1094
5.
Biniam Kidane MD MSc Ian J. Gerard MD PhD Jonathan Spicer MD PhD Julian O. Kim MD MSc BEng Pierre O. Fiset MD PhD Paul Wawryko MD Matthew J. Cecchini MD PhD Richard Inculet MD Bassam Abdulkarim MD PhD Dalilah Fortin MD Mehdi Qiabi MD MSc Gefei Qing MD Stephanie Enns BSc Bashir Bashir MBBS James Tankel MD Elliot Wakeam MD Andrew Warner MSc Neil Kopek MD Brian P. Yaremko MD MSc PEng George B. Rodrigues MD PhD Joanna M. Laba MD Melody Qu MD MPH Richard A. Malthaner MD MSc David A. Palma MD PhD 《Cancer》2023,129(18):2798-2807
Background
During coronavirus disease 2019 (COVID-19)–related operating room closures, some multidisciplinary thoracic oncology teams adopted a paradigm of stereotactic ablative radiotherapy (SABR) as a bridge to surgery, an approach called SABR-BRIDGE. This study presents the preliminary surgical and pathological results.Methods
Eligible participants from four institutions (three in Canada and one in the United States) had early-stage presumed or biopsy-proven lung malignancy that would normally be surgically resected. SABR was delivered using standard institutional guidelines, with surgery >3 months following SABR with standardized pathologic assessment. Pathological complete response (pCR) was defined as absence of viable cancer. Major pathologic response (MPR) was defined as ≤10% viable tissue.Results
Seventy-two patients underwent SABR. Most common SABR regimens were 34 Gy/1 (29%, n = 21), 48 Gy/3–4 (26%, n = 19), and 50/55 Gy/5 (22%, n = 16). SABR was well-tolerated, with one grade 5 toxicity (death 10 days after SABR with COVID-19) and five grade 2–3 toxicities. Following SABR, 26 patients underwent resection thus far (13 pending surgery). Median time-to-surgery was 4.5 months post-SABR (range, 2–17.5 months). Surgery was reported as being more difficult because of SABR in 38% (n = 10) of cases. Thirteen patients (50%) had pCR and 19 (73%) had MPR. Rates of pCR trended higher in patients operated on at earlier time points (75% if within 3 months, 50% if 3–6 months, and 33% if ≥6 months; p = .069). In the exploratory best-case scenario analysis, pCR rate does not exceed 82%.Conclusions
The SABR-BRIDGE approach allowed for delivery of treatment during a period of operating room closure and was well-tolerated. Even in the best-case scenario, pCR rate does not exceed 82%. 相似文献6.
Shareen Forbes Anneliese J. Flatt Denise Bennett Robert Crookston Mirka Pimkova Linda Birtles Andrew Pernet Ruth C. Wood Keith Burling Peter Barker Claire Counter Alistair Lumb Pratik Choudhary Martin K. Rutter Miranda Rosenthal Andrew Sutherland John Casey Paul Johnson James A. M. Shaw 《American journal of transplantation》2022,22(1):154-164
The UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after program inception to evaluate associations between transplanted mass; single versus two transplants; time between two transplants and graft survival (stimulated C-peptide >50 pmol/L) and function. In total, 84 islet transplant recipients were studied. Uninterrupted graft survival over 12 months was attained in 23 (68%) single and 47 (94%) (p = .002) two transplant recipients (separated by [median (IQR)] 6 (3–8) months). 64% recipients of one or two transplants with uninterrupted function at 12 months sustained graft function at 6 years. Total transplanted mass was associated with Mixed Meal Tolerance Test stimulated C-peptide at 12 months (p < .01). Despite 1.9-fold greater transplanted mass in recipients of two versus one islet infusion (12 218 [9291–15 417] vs. 6442 [5156–7639] IEQ/kg; p < .0001), stimulated C-peptide was not significantly higher. Shorter time between transplants was associated with greater insulin dose reduction at 12 months (beta ?0.35; p = .02). Graft survival over the first 12 months was greater in recipients of two versus one islet transplant in the UK program, although function at 1 and 6 years was comparable. Minimizing the interval between 2 islet infusions may maximize cumulative impact on graft function. 相似文献
7.
Ibrahim Aldoss MD Salman Otoukesh MD Jianying Zhang PhD Sally Mokhtari PhD Dat Ngo PharmD Mona Mojtahedzadeh MD Monzr M. Al Malki MD Amandeep Salhotra MD Haris Ali MD Ahmed Aribi MD Karamjeet S. Sandhu MD Shukaib Arslan MD Paul Koller MD Brian Ball MD Forrest Stewart MD Peter Curtin MD Andrew Artz MD Ryotaro Nakamura MD Guido Marcucci MD Stephen J. Forman MD Anthony S. Stein MD Vinod Pullarkat MD 《Cancer》2022,128(3):529-535
8.
9.
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure
Della Guardia Lucio Shin Andrew C. 《Journal of molecular medicine (Berlin, Germany)》2022,100(5):665-676
Journal of Molecular Medicine - Chronic exposure to high levels of particulate matter (PM) is correlated to a higher prevalence of cardio-metabolic disturbances. Adipose tissue represents a pivotal... 相似文献
10.
Lu Victor Zhang James Zhou Andrew Krkovic Matija 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2022,32(6):1119-1126
European Journal of Orthopaedic Surgery & Traumatology - The management of limb-length discrepancy secondary to traumatic femoral bone loss poses a unique challenge for surgeons. The Ilizarov... 相似文献