全文获取类型
收费全文 | 2169篇 |
免费 | 123篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 84篇 |
妇产科学 | 61篇 |
基础医学 | 372篇 |
口腔科学 | 101篇 |
临床医学 | 153篇 |
内科学 | 457篇 |
皮肤病学 | 45篇 |
神经病学 | 180篇 |
特种医学 | 59篇 |
外国民族医学 | 1篇 |
外科学 | 245篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 208篇 |
眼科学 | 20篇 |
药学 | 145篇 |
中国医学 | 17篇 |
肿瘤学 | 131篇 |
出版年
2023年 | 26篇 |
2022年 | 11篇 |
2021年 | 56篇 |
2020年 | 65篇 |
2019年 | 54篇 |
2018年 | 75篇 |
2017年 | 41篇 |
2016年 | 61篇 |
2015年 | 76篇 |
2014年 | 75篇 |
2013年 | 108篇 |
2012年 | 144篇 |
2011年 | 174篇 |
2010年 | 86篇 |
2009年 | 53篇 |
2008年 | 106篇 |
2007年 | 117篇 |
2006年 | 127篇 |
2005年 | 98篇 |
2004年 | 93篇 |
2003年 | 90篇 |
2002年 | 70篇 |
2001年 | 31篇 |
2000年 | 41篇 |
1999年 | 43篇 |
1998年 | 22篇 |
1997年 | 18篇 |
1996年 | 18篇 |
1995年 | 18篇 |
1994年 | 9篇 |
1993年 | 15篇 |
1992年 | 35篇 |
1991年 | 25篇 |
1990年 | 33篇 |
1989年 | 23篇 |
1988年 | 20篇 |
1987年 | 19篇 |
1986年 | 20篇 |
1985年 | 16篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 4篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1974年 | 6篇 |
1971年 | 9篇 |
1969年 | 3篇 |
排序方式: 共有2307条查询结果,搜索用时 15 毫秒
1.
High prevalence of toothache among Great East Japan Earthquake survivors living in temporary housing
2.
Background
The aims of the study are to evaluate attitudes about childhood vaccines and vaccine refusal or delay among parents and to assess the role played by the variables mapped as potential determinants to suggest strategies that could improve childhood vaccination rates.Methods
The cross-sectional study was intended for parents of kindergarteners. Parental attitudes were measured using the Parent Attitudes about Childhood Vaccines (PACV) survey, to screen for Vaccine Hesitancy (VH). In addition, selected factors have been grouped in three categories (contextual, individual and group and vaccine/vaccination-specific influences), and were explored as potential determinant of VH and vaccination refusal or delay.Results
7.7% of subjects were defined as VH parents (VHPs) through PACV score, while 24.6% reported having refused or delayed at least one dose of vaccine for their child. VH was more common in those parents that decided not to vaccinate their child after having received information from mass-media, in those who did not agree with mandatory vaccinations, and in those who agreed with political leaders who oppose to vaccination. Vaccine refusing/delaying parents were more frequently those who agreed that infant vaccinations are primarily an economic business of pharmaceutical companies, and who disagreed that access to the kindergarten should only be allowed to children who had been vaccinated.Conclusion
The findings of the present study emphasize the importance of PACV as a tool to screen VHPs. Furthermore, results highlight important potential determinants of VH, such as communication and media environment, and attitudes about prevention. Health care providers could act as key components to improve the public trust to scientific and epidemiological evidence. 相似文献3.
Eva E. Tejerina Elena Abril Rebeca Padilla Covadonga Rodríguez Ruíz Aida Ballen Fernando Frutos‐Vivar Jos ngel Lorente Andrs Esteban 《Mycoses》2019,62(8):673-679
Autopsy studies show that IA is among the most commonly missed diagnoses in critically ill patients. And, because of lack of unequivocal diagnostic criteria, a timely diagnosis remains challenging. We investigate the epidemiology of and the clinical risk factors for IA in critically ill patients. We conducted a retrospective, observational study of all consecutive ICU patients with evidence of IA in the postmortem examination. During the period of the study (25 years), 893 postmortem examinations were performed in the ICU. Twenty‐five patients (2.8%) were diagnosed with IA in autopsy. Only ten (40%) were classified as IA ante‐mortem, based on the initiation of antifungal treatment. The most common comorbid conditions were corticosteroid treatment (n = 14, 56%), chronic obstructive pulmonary disease (COPD) (n = 11, 44%), immunosuppression (n = 6, 24%) and haematological malignancy (n = 5, 20%). Twenty‐three patients (92%) had three or more risk factors for IA. Critically ill patients with pulmonary infiltrates, treated with high doses intravenous corticosteroids (even for a short period of time), particularly COPD patients who developed worsening respiratory insufficiency despite appropriate treatment were at the highest risk of IA. 相似文献
4.
5.
6.
Arvydas Laurinavicius Andrew R. Green Aida Laurinaviciene Giedre Smailyte Valerijus Ostapenko Raimundas Meskauskas Ian O. Ellis 《Oncotarget》2015,6(38):41134-41145
Biological diversity of breast cancer presents challenges for personalized therapy and necessitates multiparametric approaches to understand and manage the disease. Multiple protein biomarkers tested by immunohistochemistry (IHC), followed by digital image analysis and multivariate statistics of the data, have been shown to be effective in exploring latent profiles of tumor tissue immunophenotype. In this study, based on tissue microarrays of 107 patients with hormone receptor (HR) positive invasive ductal breast carcinoma, we investigated the prognostic value of the integrated immunophenotype to predict overall survival (OS) of the patients. A set of 10 IHC markers (ER, PR, HER2, Ki67, AR, BCL2, HIF-1α, SATB1, p53, and p16) was used. The main factor of the variance was characterized by opposite loadings of ER/PR/AR/BCL2 and Ki67/HIF-1α; it was associated with histological grade but did not predict OS. The second factor was driven by SATB1 expression along with moderate positive HIF-1α and weak negative Ki67 loadings. Importantly, this factor did not correlate with any clinicopathologic parameters, but was an independent predictor of better OS. Ki67 and SATB1 did not reach statistical significance as single predictors; however, high Ki67/SATB1 ratio was an independent predictor of worse OS. In addition, our data indicate potential double prognostic meaning of HIF-1α expression in breast cancer and necessitate focused studies, taking into account the immunophenotype interactions and tissue heterogeneity aspects. 相似文献
7.
José A. Lorente Pablo Cardinal-Fernández Diego Muñoz Fernando Frutos-Vivar Arnaud W. Thille Carlos Jaramillo Aida Ballén-Barragán José M. Rodríguez Oscar Peñuelas Guillermo Ortiz José Blanco Bruno Valle Pinheiro Nicolás Nin María del Carmen Marin Andrés Esteban Taylor B. Thompson 《Intensive care medicine》2015,41(11):1921-1930
8.
9.
Marrero-González Paula Iranzo Alex Bedoya David Serradell Mònica Niñerola-Baizán Aida Perissinotti Andrés Gaig Carles Vilaseca Isabel Alobid Isam Santamaría Joan Mullol Joaquim 《Journal of neurology》2020,267(12):3673-3682
Journal of Neurology - Idiopathic hyposmia (IH) is a prodromal marker of Parkinson disease (PD). However, IH is common in the general population and only a minority will develop PD. Identification... 相似文献
10.