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1.
Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancy. 总被引:4,自引:0,他引:4
Jeffrey R Wienke Wui K Chong Julia R Fielding Kelly H Zou Carol A Mittelstaedt 《Journal of ultrasound in medicine》2003,22(10):1027-1031
OBJECTIVE: To prospectively determine the sonographic findings of nodular hyperplasia of the thyroid, to compare these with reported findings associated with malignancy, and to assess interobserver reliability. METHODS: Seventy thyroid nodules were scanned, and then biopsies of the nodules were performed under sonographic guidance with fine-needle cytologic analysis; in all cases images were reviewed by 2 experienced radiologists without knowledge of clinical outcome. Findings reported associated with malignancy were specifically assessed. Interobserver agreement between the expert and secondary readers for each finding was calculated by the kappa or weighted kappa statistic and the Fisher exact test of independence. RESULTS: There were 68 benign and 2 malignant nodules in a population of 63 female and 7 male patients. The mean benign nodule size was 2.9 cm; 60% were solid; 54% were hypoechoic; 59% were microlobulated or macrolobulated; 47% had central vascularity; 24% contained calcifications; and 82% were elliptical in shape. There was very good interobserver reliability for the presence of calcium (kappa = 0.91) and good agreement for the presence and location of vascularity (kappa = 0.75) and the amount of cystic components (kappa = 0.62; all P < .01). CONCLUSIONS: Sixty-nine percent of benign nodules had at least 1 finding reported previously as associated with malignancy. The interobserver reliability of the sonographic findings was good to very good for 3 of the 5 findings assessed. 相似文献
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3.
目的:探讨靶重建放大扫描技术对肺孤立性结节病变的诊断价值。方法:对63例患者先行常规CT平扫,选定结节处为兴趣区,行薄层靶重建放大扫描,层厚、层距为2mm,FOV为160。结果:42例恶性病变中有37例表现为深分叶,占88.1%;21例良性病变中有15例表现为浅分叶,占71.4%。恶性结节中15例内部出现条状低密度支气管征;7例出现血管集中征;8例出现空泡征;病变内部出现液化坏死13例,其中恶性病变ll例。22例出现钙化,包括12例良性病变和10例恶性病变。2例错构瘤内均见小面积脂肪性低密度影。结论:靶重建放大扫描比普通CT扫描可提供更多的信息,对良恶性病变的鉴别诊断有一定价值。恶性病变大多数为深分叶,良性病变大多数为浅分叶或无分叶。 相似文献
4.
The morphological changes produced in the thyroid glands of albino rats following radiation with a 904 nm infrared laser were studied. Two different levels of radiation were applied: 46.8 J/cm2 and 140.4 J/cm2. Evaluation of the changes in the densities of the epithelial, colloidal and follicular volumes and of the activation index revealed that the laser beam produced changes in the thyroid parenchyma. It was observed that there was a direct relationship between the severity of the lesion and the radiation energy applied. 相似文献
5.
Thyroid storm as a cause of loss of consciousness following anaesthesia for emergency Caesarean section 总被引:1,自引:0,他引:1
A previously undiagnosed thyrotoxic patient was anaesthetised for an emergency Caesarean section. The recovery period was complicated by an acute thyroid crisis resulting in loss of consciousness following an apparently normal recovery from general anaesthesia. 相似文献
6.
目的 :观察血清保存方法对促甲状腺激素 (TSH)结果的影响。方法 :将甲状腺功能正常、异常患者共 10份血清 ,采用不同血清量、不同条件分组保存后测定 TSH。结果 :保存方法对 TSH结果有一定的影响。结论 :用于 TSH血清的保存量要多、要密封管口、低温保存。 相似文献
7.
硫代葡萄糖甙对碘代谢和甲状腺的影响 总被引:1,自引:0,他引:1
猪饲喂8%~16%英籽饼日粮,平均每日从日粮中摄入919.42~1416.02mg硫代葡萄糖甙。在连续饲喂120天后,其甲状腺肿大,甲状腺滤泡和甲状腺上皮细胞显著增生,细胞质内缺乏分泌颗粒和溶酶体,细胞顶端密集微绒毛;滤泡腔内胶质周边部具有大量吸收空泡,分泌功能旺盛。T_4和T_4/T_3比值明显升高,甲状腺功能亢进。若日粮中增加给碘量和服用解毒剂,猪甲状腺的组织形态学和超微结构接近正常,T_4和/T_4/T_3比值亦趋于正常。 相似文献
8.
随机选择经长期随访证实的滤泡性甲状腺癌和腺瘤各10例,正常甲状腺组织5例作为对照。按Ploton的染色方法和Crocker推荐的计数方法分别计算三组每例各50个细胞的Ag-NOR嗜银颗粒平均数,再算出三组各自的AgNOR均数,经统计学检验三者有极显著性差异。可望成为甲状腺滤泡性肿瘤良恶鉴别的一项辅助指标。 相似文献
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10.
Markus Dietlein Klemens Scheidhauer Eberhard Voth Peter Theissen Harald Schicha 《European journal of nuclear medicine and molecular imaging》1997,24(11):1342-1348
Metastases of differentiated thyroid cancer may show different uptake patterns for fluorine-18 fluorodeoxyglucose and [131I]NaI. FDG positron emission tomography (PET), iodine-131 whole-body scintigraphy (131I WBS) and magnetic resonance imaging were performed in 58 unselected patients, and spiral computed tomography (CT) of the
lung in 25 patients. Thirty-eight patients presented with papillary carcinomas, 15 patients with follicular carcinomas and
five patients with variants of follicular carcinoma. Primary tumour stage (pT) was pT1 in 3, pT2 in 19, pT3 in 11 and pT4
in 25 cases. For the detection of metastases, FDG PET was found to have a sensitivity of 50%, 131I WBS a sensitivity of 61%, and the two methods combined a sensitivity of 86%. When FDG PET was limited to patients with elevated
thyroglobulin (Tg) levels and negative 131I WBS, the sensitivity of this algorithm was 82%. Of the 21 patients with lymph node metastases, seven presented with FDG
uptake but no iodine uptake. In four of them, a second FDG hot spot appeared in a lymph node metastasis of normal size. Five
of the seven patients underwent surgery. None of the eight patients with pulmonary metastases smaller than 1 cm exhibited
FDG uptake, while five of them had iodine uptake. All had positive results on spiral CT. In conclusion, FDG PET cannot be
substituted for 131I WBS. If the Tg level is elevated and 131I WBS is negative, FDG PET can be used to detect lymph node metastases and complements anatomical imaging. A spiral CT of
the lung is useful to exclude pulmonary metastases before planning a dissection of iodine-negative lymph node metastases.
Received 2 May and in revised form 8 July 1997 相似文献