全文获取类型
收费全文 | 17564篇 |
免费 | 1804篇 |
国内免费 | 1068篇 |
专业分类
耳鼻咽喉 | 123篇 |
儿科学 | 240篇 |
妇产科学 | 287篇 |
基础医学 | 3797篇 |
口腔科学 | 336篇 |
临床医学 | 1466篇 |
内科学 | 3693篇 |
皮肤病学 | 378篇 |
神经病学 | 900篇 |
特种医学 | 328篇 |
外国民族医学 | 12篇 |
外科学 | 1540篇 |
综合类 | 2634篇 |
现状与发展 | 2篇 |
预防医学 | 660篇 |
眼科学 | 227篇 |
药学 | 1403篇 |
3篇 | |
中国医学 | 227篇 |
肿瘤学 | 2180篇 |
出版年
2023年 | 422篇 |
2022年 | 564篇 |
2021年 | 1039篇 |
2020年 | 817篇 |
2019年 | 755篇 |
2018年 | 635篇 |
2017年 | 552篇 |
2016年 | 642篇 |
2015年 | 778篇 |
2014年 | 1108篇 |
2013年 | 1066篇 |
2012年 | 1104篇 |
2011年 | 1234篇 |
2010年 | 1077篇 |
2009年 | 1113篇 |
2008年 | 1091篇 |
2007年 | 989篇 |
2006年 | 855篇 |
2005年 | 680篇 |
2004年 | 498篇 |
2003年 | 357篇 |
2002年 | 280篇 |
2001年 | 312篇 |
2000年 | 255篇 |
1999年 | 217篇 |
1998年 | 195篇 |
1997年 | 169篇 |
1996年 | 117篇 |
1995年 | 127篇 |
1994年 | 128篇 |
1993年 | 106篇 |
1992年 | 95篇 |
1991年 | 71篇 |
1990年 | 60篇 |
1989年 | 63篇 |
1988年 | 67篇 |
1987年 | 46篇 |
1986年 | 39篇 |
1985年 | 76篇 |
1984年 | 78篇 |
1983年 | 49篇 |
1982年 | 51篇 |
1981年 | 77篇 |
1980年 | 74篇 |
1979年 | 45篇 |
1978年 | 56篇 |
1977年 | 28篇 |
1976年 | 51篇 |
1975年 | 28篇 |
1974年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
We have been experiencing multiple waves of the coronavirus disease 2019 (COVID-19) pandemic. With these unprecedented waves, we have entered into an era of ‘new normal’. This pandemic has enforced us to rethink the very basics of childhood learning: Habits, health etiquette, and hygiene. Rehabilitation has immense importance during this pandemic considering a few aspects. Multidis ciplinary COVID-19 rehabilitation clinics are essential to address the demand. The equitable distribution of COVID-19 rehabilitation services for differently-abled individuals during the pandemic is an important aspect. Rehabilitation needs identification and further studies on various rehabilitation interventions are among the key unmet future research needs. 相似文献
4.
- DNA is the sequence that codes for proteins.
- Messenger RNA is transcribed from the DNA sequence of genes and translated into protein.
- It can be difficult to predict how a change in the DNA sequence will affect messenger RNA and protein quantity and quality.
- DNA translocation changes can cause the joining of sequences from two different genes or different parts of the same gene.
- DNA sequencing is often used clinically to predict how DNA changes might affect proteins.
- Alternatively, RNA sequencing can be used as a more direct measure of the effect of DNA changes on the protein products.
- This sequencing is important for identifying changes in cancer that may indicate response to targeted therapy, prognosis, or diagnosis.
5.
6.
7.
8.
Dan-Dan Shan Qiu-Xian Zheng Jing Wang Zhi Chen 《World journal of gastroenterology : WJG》2022,28(16):1641-1655
Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function extensively in numerous physiological and pathological processes. Small nucleolar RNA host gene 3 (SNHG3) is a novel lncRNA and has been reported to be differentially expressed in various tumors, such as liver cancer, gastric cancer, and glioma. However, the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly understood. In this review, we summarize the results of SNHG3 studies in humans, animal models, and cells to underline the expression and role of SNHG3 in cancer. SNHG3 expression is upregulated in most tumors and is detrimental to patient prognosis. SNHG3 expression in lung adenocarcinoma remains controversial. Concurrently, SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms, including competing endogenous RNA effects. A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment. 相似文献
9.
《Journal of pediatric surgery》2023,58(4):629-632
BackgroundLeft-sided repair for long gap esophageal atresia (LGEA) has been described for patients with a large leftward upper pouch, no thoracic tracheoesophageal fistula (TEF) nor tracheobronchomalacia (TBM), or as salvage plan after prior failed right-sided repair. We describe our experience with left-sided MIS traction induced growth process.MethodsWe retrospectively reviewed patients who underwent Foker process for LGEA at two institutions between December 2016 and November 2021. Patient characteristics, surgical techniques, and outcomes were reviewed.Results71 patients underwent Foker process. Of 34 MIS cases, 28 patients (82%) underwent left-sided repair (median gap length 5 cm) at median age 4 months with median 3 (range 2–8) operations and median 13.5 (IQR 11–21) days on traction until esophageal anastomosis. 9 patients (32%) underwent completely MIS approach, whereas 5 patients (18%) converted to open at first operation and 14 patients (50%) converted to open later in the traction process. Traction was internal in 68%, external in 11%, and combination in 21%. Median follow-up was 15.4 (IQR 7.5–31.7) months after anastomosis. 14% had anastomotic leak managed with antibiotics and/or esophageal vacuum therapy. Median number of esophageal dilations was 3.5 (range 0–13). 18% required stricture resection. 39% underwent Nissen fundoplication. None have needed esophageal replacement.ConclusionsFor multiple reasons including the tendency of both esophageal pouches to have a leftward bias, less tracheal compression by upper pouch, and clean field of surgery for reoperative cases, we now more commonly use left-sided approach for MIS LGEA repair compared to right side, regardless of left aortic arch.Level of evidenceLevel IV Treatment Study. 相似文献
10.