Finite-element model of the human head: scalp potentials due to dipole sources

Three-dimensional finite-element models provide a method to study the relationship between human scalp potentials and neural current sources inside the brain. A new formulation of dipole-like current sources is developed here. Finiteelement analyses based on this formulation are carried out for both a threeconcentric-spheres model and a human-head model. Differences in calculated scalp potentials between these two models are studied in the context of the forward and inverse problems in EEG. The effects of the eye orbit structure on surface potential distribution are also studied.     

A factor analysis of the Klein sexual orientation Grid in two disparate samples

Many researchers interested in sexual orientation can be separated into two camps: The lumpers, who try to reduce sexual classifications to as small a number of categories as possible, and the splitters, who try to show differences among groups and individuals that make classification schemes increasingly difficult and/or intricate. We report factor analyses of the Klein Grid (a questionnaire with 21 sexual orientation items) to see how many factors emerge in two samples of strikingly different origins. In both samples, the first factor to emerge loaded substantially on all of the Klein Grid's 21 items. This factor accounted for a majority of the variance. In both samples, a second, correlated factor emerged which indexed a separation between most of the items and those having to do with social and/or emotional preferences. In both samples, a third correlated factor also emerged, but this factor differed between the two populations: one refined the social/emotional distinction and the other distinguished ideal behavior from past and current behavior. We conclude on the basis of our analysis that both the lumpers and the splitters are correct.Supported by NIMH grants IP50 MH 45294 and R01 MH 43298.     

Foreign Bodies in Facial Trauma-Report of 3 Cases

Background

Foreign bodies embedded deep in facial tissues presents a challenge to maxillofacial surgeons. Approximately one third of all foreign bodies are missed during initial examination. After facial trauma foreign bodies like grit particles, wooden pieces, thorns, pebbles, glass particles may get embedded into deeper facial tissues which are detected only accidently either with the help of radiographs or at a later stage when patient presents with some signs & symptoms like pain, pus discharge, sinus formation etc. Trauma to maxillofacial region especially after road traffic accidents is one of major cause of embedment of foreign body, but many of these cases go unnoticed. This article contains 3 cases of foreign bodies embedded in facial tissues.

Conclusion

Proper initial examination of facial lacerations with thorough debridement is very essential for finding embedded foreign bodies. Foreign bodies embedded in deeper tissues are missed by surgeon eyes, so whenever in doubt radiographs must be advised to rule out presence of foreign bodies.     

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system

In our previous paper (Drug Metabolism Parmacokinet 31: 363, 2016), a simulation system for ligand interactions of human CYP1A2 was developed using “Template” composed of hexagonal grids focusing on polyaromatic hydrocarbons (PAHs). The system has been expanded for the application of non-PAH chemicals including medical drugs, industrial chemicals and natural products in the present study. Additions of two Templates C and D around Ring C/E and Ring B, respectively, perpendicular each to Template A, offered the accommodation of non-PAH substrates. The size and shape of Templates C and D were defined from the reciprocal comparison of experimental data of ligands with simulation on Templates. The requirements of occupancies at Trigger region (Ring B) and at region of Facial-side Movement (Ring C) as well as Site of Oxidation were found to be mutual throughout CYP1A2 good substrates tested for over the 450 reactions, irrespective of their shapes and flexibilities. The CYP1A2 Template system was also verified with distinct types of poor substrates (47 chemicals) and inhibitors (37 inhibitors) and found to offer the information on probable structural causes. Present CYP1A2 Template system offers a unified evaluation of human CYP1A2 ligands, which aids for toxicological assessments as well as drug metabolism studies.     

网格环境下基于编码机制的数据复制研究

本文提出了基于编码机制的网格数据复制思想,通过对副本数据进行线性分组编码,并将其分散保存到网格存储节点,可形成具有纠删能力的编码子副本组.针对目前热点研究的线性分组编码,探讨基于Cauchy Reed-Solo-mon Code、Tornado Code和Random Linear Code的编码数据复制方案,通过建模手段讨论三者的副本数据访问性能和副本数据可靠性,并与传统的完整数据复制和分块数据复制进行时比分析,证明所提出的编码数据复制有着较优的综合性能.具体实验数据进一步说明,编码副本的编码开销占整个数据复制开销的较小比例,表明编码数据复制是具有可行性的技术方案.     

A cross-platform model for secure Electronic Health Record communication

During the past decade, there have been many regional, national and European projects focused on the development of platforms for secure access and sharing of distributed patient information. A platform is needed because present local or enterprise-wide information systems are typically not intended for cross-organisational secure access of patient data. Most of the present secure platforms are local or regional. Commonly used platform types in the health care environment vary from secure point-to-point communication systems to internet-based portals. This paper defines an enhanced cross-security platform which makes it possible for different kinds of local, regional, and national health information systems to communicate in a secure way. The proposed evolutionary way interconnects regional or national security domains with the help of a cross-platform zone. A more revolutionary model based on peer-to-peer Grid like networks and dynamic security credentials is also discussed. The proposed evolutionary model uses cross-domain security and interoperability services to ensure secure communication and interoperability between different security domains. The platform supports both communication defined beforehand and adhoc dynamic access to distributed electronic health records (EHRs). The internet is proposed as the "glue" between different regional or national security domains.     

Depressive tendency of design major freshman students explored through the use of color in mosaic creations

Depression is affecting a growing number of people, while the age of its first occurrence continues to lower; there is a rapid increase in youths with depression. Many therapies use art as a tool; the process of creation allows the therapist to understand the thoughts and feelings of depression patients. This study quantifies the color usage principles and abstract feelings from the perspective of the artist, and further considers whether there are differences in color cognition between those with or without depressive tendencies. The participants were 120 college freshman design students, and the CES-D was used to test the subjects’ degree of depression. Afterwards, the subjects were asked to participate in creating a mosaic with the theme “different selves,” and to offer their own explanation of the principles and feelings related to the use of color in the creative work. One-third of the 120 subjects had depressive tendencies. The results showed a correlation between depressive tendency and the use of color in the “different selves” mosaic, with subjects having depressive tendencies showing a greater use of dark colors. Those subjects with no depressive tendencies were more likely to use “cool colors” to represent depression, while those subjects with depressive tendencies more often used “dark colors” to express depression. This study found that there is a correlation between the presence of depressive tendency and this specific use of color among freshman design students.     

GridIMAGE: A Novel Use of Grid Computing to Support Interactive Human and Computer-Assisted Detection Decision Support

This paper describes a Grid-aware image reviewing system (GridIMAGE) that allows practitioners to (a) select images from multiple geographically distributed digital imaging and communication in medicine (DICOM) servers, (b) send those images to a specified group of human readers and computer-assisted detection (CAD) algorithms, and (c) obtain and compare interpretations from human readers and CAD algorithms. The currently implemented system was developed using the National Cancer Institute caGrid infrastructure and is designed to support the identification of lung nodules on thoracic computed tomography. However, the infrastructure is general and can support any type of distributed review. caGrid data and analytical services are used to link DICOM image databases and CAD systems and to interact with human readers. Moreover, the service-oriented and distributed structure of the GridIMAGE framework enables a flexible system, which can be deployed in an institution (linking multiple DICOM servers and CAD algorithms) and in a Grid environment (linking the resources of collaborating research groups). GridIMAGE provides a framework that allows practitioners to obtain interpretations from one or more human readers or CAD algorithms. It also provides a mechanism to allow cooperative imaging groups to systematically perform image interpretation tasks associated with research protocols.     

Use of an ultrasound blood-mimicking fluid for Doppler investigations of turbulence in vitro

Turbulence is an important factor in the assessment of stenotic disease and a possible causative mechanism for thromboembolism. Previous Doppler studies of turbulence have typically used whole-blood preparations or suspensions of erythrocytes. Recently, a water-glycerol based blood-mimicking fluid (BMF) has been developed for use in Doppler ultrasound studies. This fluid has desirable ultrasound properties but it has not previously been described during in vitro investigations of turbulence intensity. We report on investigations of grid-generated and constrained-jet turbulence in an in vitro test system. The BMF was found to generate significant levels of turbulence during steady flow at physiological flow rates, producing turbulent patterns in the distal region that were consistent with previous studies. Turbulence intensity increased significantly with flow rate (p < 0.005) for both the constrained jet and the constrained grid. Based on our observations, we conclude that a water-glycerol based BMF provides a suitable working fluid during in vitro investigations of turbulence using Doppler ultrasound.     

用数字滤波技术测定滤线栅密度

本文介绍一种采用数字滤波技术，微机实时处理，实现滤线栅密度测试的新方法。实测结果表明。比现用的照像测试法客观准确，工作效率提高数十倍以上。