Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model

BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction.     

Chagas cardiomyopathy and heart failure: From epidemiology to treatment

Chagas disease is among the neglected tropical diseases recognized by the World Health Organization that have received insufficient attention from governments and health agencies.Chagas disease is endemic in 21 Latin America regions. Due to globalization and increased migration, it has crossed borders and reached other regions including North America and Europe. The clinical presentation of the disease is highly variable, from general symptoms to severe cardiac involvement that can culminate in heart failure. Chagas heart disease is multifactorial, and can include dilated cardiomyopathy, thromboembolic phenomena, and arrhythmias that may lead to sudden death. Diagnosis is by methods such as enzyme-linked immunosorbent assay (ELISA) and the degree of cardiac involvement should be investigated with complementary exams including ECG, chest radiography and electrophysiological study. There have been insufficient studies on which to base specific treatment for heart failure due to Chagas disease. Treatment should therefore be derived from guidelines for heart failure that are not specific for this disease. Heart transplantation is a viable option with satisfactory success rates that has improved survival.     

膜周部室间隔缺损介入封堵术后心律失常危险因素及转归分析

目的 探讨膜周部室间隔缺损(PmVSD)介入封堵术后心律失常的危险因素和转归.方法 选择2019年1月至2021年2月在安徽省儿童医院心内科行PmVSD介入封堵术69例患儿为研究对象,回顾性分析患儿的临床资料、心电图和/或动态心电图、经胸超声心动图、术中心导管检查以及术后随访资料,按照是否发生心律失常,分为心律失常组(n=9)与非心律失常组(n=60),采用多因素logistic回归分析PmVSD介入封堵术后心律失常的危险因素.结果 心律失常组患儿QRS间期为109.00(93.50,127.50)ms,非心律失常组患儿QRS间期为74.00(71.25,78.00)ms,两组差异有统计学意义(P<0.05).两组患儿缺损直径、肺循环/体循环血流量比值(Qp/Qs)和曝光时间进行比较,差异有统计学意义(P<0.05),多因素logistic回归分析显示,曝光时间延长是PmVSD介入封堵术后心律失常发生的危险因素(OR=1.416,95％CI:1.120～1.790,P<0.05).随访12.00(6.00,12.00)个月,7例(包括2例严重心律失常)心律失常患儿恢复窦性心律.结论 PmVSD介入封堵术后心律失常以束支传导阻滞多见,大部分术后早期可恢复正常,曝光时间延长可增加PmVSD封堵术后心律失常的发生.     

稳心颗粒联合β受体阻断剂治疗冠心病心律失常的临床疗效研究

目的：探讨稳心颗粒联合β受体阻断剂治疗冠心病心律失常的临床疗效。方法选取武义县白洋街道社区卫生服务中心心血管内科2012年收治的冠心病心律失常患者150例,以随机抽样方法分为对照组和观察组,每组75例。对照组给予β受体阻断剂酒石酸美托洛尔单用治疗,观察组在对照组基础上加用稳心颗粒治疗;比较两组患者临床疗效、治疗前后心律失常改善情况及12导联心电图ST段压低程度。结果观察组患者临床疗效优于对照组,差异有统计学意义（ P<0.05）。治疗后观察组患者室性期前收缩和房性期前收缩发生频率低于对照组,两组患者治疗后室性期前收缩和房性期前收缩发生频率均低于治疗前,差异有统计学意义（ P<0.05）。观察组患者治疗后12导联心电图ST段压低程度低于对照组,两组患者治疗后12导联心电图ST段压低程度低于治疗前,差异有统计学意义（P<0.05）。两组患者治疗期间不良反应发生率比较,差异无统计学意义（P>0.05）。结论稳心颗粒联合β受体阻断剂治疗冠心病心律失常可有效缓解临床症状,改善夜间睡眠,改善心律失常发生频率及程度。     

16例心肌致密化不全的临床特征

目的 分析16例心肌致密化不全(NVM)患者的临床特征和心脏彩超特点.方法 分析来自4个家系的9例NVM患者以及7例散发性NVM患者的临床表现、心电图、超声心动图等资料.结果 16例NVM患者,男12例,发病年龄17-74岁.7例患者有心悸症状;7例散发性NVM患者和2例家族性NVM患者有不同程度的心力衰竭;6例家族性NVM患者无明显症状.心电图异常者12例:室性期前收缩5例,非持续性室性心动过速3例,持续性房颤2例,阵发性房扑房颤1例,ST段压低伴T波改变9例.所有患者均通过心脏超声检查确诊,患者病变均局限于左心室;其中,累及心尖部14例,左心室扩大10例,左心室射血分数减低8例,左心室内见多发血栓1例.结论 NVM男性患者多见,有家族遗传倾向;其临床表现主要为心力衰竭、心律失常,超声心动图是确诊的主要方法.     

心血管离子通道病的研究现状

心血管离子通道病是离子通道病的重要组成部分。作为原发或继发病因离子通道病变几乎参与了所有的心血管疾病的发生发展过程，是心脏性猝死的主要原因。本文对遗传性心脏离子通道病、获得性心脏离子通道病以及离子通道与血管疾病进行综述，并简要介绍了心血管离子通道病的治疗。