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1.
[目的] 探讨360度心理支持对非小细胞肺癌胸腔镜肺叶切除术患者术后快速康复的效果观察。[方法]选择2018年1月至2018年9月在我院行胸腔镜肺叶切除术治疗的174例NSCLC肺癌患者作为研究对象,采用随机数字表法分为对照组和观察组各87例。对照组采用常规手术室护理干预,观察组在对照组的基础上给予360度心理支持。观察术前1d和入室后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、收缩压(SBP)、舒张压(DBP)、心率(HR)水平,统计2组护理满意度、拔管天数和住院天数、术前2d及术后3d的睡眠质量、术后并发症的发生率。[结果]观察组入室后SAS和SDS评分均低于对照组,差异均有统计学意义(P<0.05)。入室后观察组患者SBP、DBP、HR均低于对照组,差异均有统计学意义(P<0.05)。观察组护理满意度显著高于对照组,差异有统计学意义(P<0.05)。观察组拔管天数和住院天数均低于对照组(P<0.05),睡眠质量优于对照组、并发症少于对照组。[结论]360度心理支持用于非小细胞肺癌患者胸腔镜肺叶切除术手术室护理可改善患者的负性心理,减轻应激状态,提高护理满意度,有利于手术的顺利实施和术后的快速康复。  相似文献   
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目的运用360度评价对我院住培学员的岗位胜任力进行评价,对学员岗位胜任力的现状进行探讨分析。方法使用问卷调查表分别从专业基地教学主任、学员指导教师、同专业学员及学员本人的角度,对2017级222名住培学员的岗位胜任力进行360度评价,利用SPSS22.0对数据进行统计分析。结果连续两年的测评,住院学员8类岗位胜任力的自评和他评得分低于满分,学员在临床基本能力、医患沟通能力、掌握与运用医学知识、团队合作能力4项内容的评分,差异有统计学意义(P<0.05);同时学员在临床基本能力、医生职业精神与素质、医患沟通能力、掌握与运用医学知识、团队合作能力5项内容的评分较上一年相比,差异也有统计学意义(P<0.05)。结论调查结果提示360度评价可帮助住培学员提高岗位胜任力,后续培训应围绕调查结果和以岗位胜任力为导向来调整与设置,需增加人文属性内容的培训以及再量化培训测评内容、指标和进一步完善考评反馈机制。  相似文献   
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《Vaccine》2016,34(39):4698-4705
African swine fever virus (ASFV) encodes multiple copies of MGF360 and MGF530/505 gene families. These genes have been implicated in the modulation of the type I interferon (IFN) response. We investigated the effect of modulating the IFN response on virus attenuation and induction of protective immunity by deleting genes MGF360 (MGF360-10L, 11L, 12L, 13L, 14L) and MGF530/505 (MGF530/505-1R, 2R and 3R) and interrupting genes (MGF360-9L and MGF530/505-4R) in the genome of the virulent ASFV isolate Benin 97/1. Replication of this deletion mutant, BeninΔMGF, in porcine macrophages in vitro was similar to that of the parental virulent virus Benin 97/1 and the natural attenuated isolate OURT88/3, which has a similar deletion of MGF360 and 530/505 genes. Levels of IFN-β mRNA in macrophages infected with virulent Benin 97/1 isolate were barely detectable but high levels were detected in macrophages infected with OURT88/3 and intermediate levels in macrophages infected with BeninΔMGF. The data confirms that these MGF360 and MGF530/505 genes have roles in suppressing induction of type I IFN. Immunisation and boost of pigs with BeninΔMGF showed that the virus was attenuated and all pigs (5/5) were protected against challenge with a lethal dose of virulent Benin 97/1. A short transient fever was observed at day 5 or 6 post-immunisation but no other clinical signs. Following immunisation and boost with the OURT88/3 isolate 3 of 4 pigs were protected against challenge. Differences were observed in the cellular and antibody responses in pigs immunised with BeninΔMGF compared to OURT88/3. Deletion of IFN modulators is a promising route for construction of rationally attenuated ASFV candidate vaccine strains.  相似文献   
5.
目的比较360度直肠腔内超声与多层螺旋CT(MSCT)对直肠癌TN分期的诊断价值。方法将我院75例直肠癌患者作为研究对象,均进行360度直肠腔内超声与MSCT检查,并以术后病理结果为标准,分析比较360度直肠腔内超声与MSCT对直肠癌术前T、N分期的诊断效能。结果术后病理结果显示,75例患者T1期、T2期、T3期及T4期分别为7例、10例、49例和9例;N0期、N1期及N2期分别为43例、20例、12例。360度直肠腔内超声、MSCT对直肠癌术前T分期诊断总准确度分别为80.00%、76.00%,与病理T分期诊断一致性分析显示Kappa值分别为0.820、0.788(均P<0.05)。360度直肠腔内超声、MSCT对直肠癌术前N分期诊断总准确度分别为77.33%、80.00%,与病理N分期诊断一致性分析显示Kappa值分别为0.773、0.800(均P<0.05)。结论360度直肠腔内超声对直肠癌术前T分期诊断效能稍优于MSCT,对直肠癌术前N分期诊断效能稍低于MSCT。  相似文献   
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ObjectiveTo determine if there were racial differences in discharge location among older adults treated for traumatic brain injury (TBI) at a level 1 trauma center.DesignRetrospective cohort study.SettingR Adams Cowley Shock Trauma Center.ParticipantsBlack and white adults aged ≥65 years treated for TBI between 1998 and 2012 and discharged to home without services or inpatient rehabilitation (N=2902).Main Outcome MeasuresWe assessed the association between race and discharge location via logistic regression. Covariates included age, sex, Abbreviated Injury Scale-Head score, insurance type, Glasgow Coma Scale score, and comorbidities.ResultsThere were 2487 (86%) whites and 415 blacks (14%) in the sample. A total of 1513 (52%) were discharged to inpatient rehabilitation and 1389 (48%) were discharged home without services. In adjusted logistic regression, blacks were more likely to be discharged to inpatient rehabilitation than to home without services compared to whites (odds ratio 1.34, 95% confidence interval, 1.06-1.70).ConclusionsIn this group of Medicare-eligible older adults, blacks were more likely to be discharged to inpatient rehabilitation compared to whites.  相似文献   
8.

Background

The Q359K/T360K mutation, described in Jewish CF patients of Georgian decent, is of questionable clinical significance.

Methods

Clinical records of patients with the Q359K/T360K mutation from three CF centers were studied for phenotypic expression and putative mechanism of dysfunction. Computer models of mutant CFTR were constructed.

Results

Nine patients (4 homozygous) of Georgian Jewish origin were included. Age at diagnosis was 9.4 (0.25–38.2) years, median (range). Sweat chloride was 106?±?13?meq/L, mean?±?SD. Nasal Potential Difference performed in three, was abnormal. All had pulmonary symptoms since early childhood and bronchiectasis. Median FEV1 was 88 (40–121)%. Five had chronic mucoid P. aeruginosa. Homozygous patients were pancreatic insufficient. Enzyme supplementation was initiated at 3.8 (1–14.7) years, median (range). Structural models hint at possible interference of this mutation with transmembrane chloride transport.

Conclusion

In our cohort, the Q359K/T360K mutation resulted in a severe CF phenotype, although with residual early CFTR function. The CFTR2 database should consider defining this mutation as CF-causing.  相似文献   
9.
背景:有研究认为骨的形态结构与其所处的应力环境密切相关。由于人类直立行走的运动方式,可能会影响髋臼骨小梁的方向。目的;观察不同物种髋臼骨小梁方向的差异。方法:X射线观察由解放军第二军医大学解剖教研室和山东大学生命科学院提供的成人双侧髋骨干燥标本和成年恒河猴髋骨标本,将采集到的图像输入Imagineproplus6.0,经快速傅里叶变换后,得出O°--180°的频谱值,计量不同的角度骨小梁的数量。结果与结论:人类髋骨在O°及90°频谱值最大,与骶耻束与髂坐束的方向符合。而恒河猴髋骨的频谱值分布较为弥散,没有明显的峰值。说明人类髋臼区域骨小梁主要沿90°及180°方向分布,与特化的骶耻束与髂坐束的方向符合,说明髂坐束的出现是与直立行走密切相关的。  相似文献   
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