首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3339篇
  国内免费   15篇
  完全免费   77篇
  神经病学   3431篇
  2017年   51篇
  2015年   22篇
  2014年   155篇
  2013年   129篇
  2012年   168篇
  2011年   297篇
  2010年   202篇
  2009年   270篇
  2008年   240篇
  2007年   250篇
  2006年   230篇
  2005年   172篇
  2004年   155篇
  2003年   176篇
  2002年   156篇
  2001年   85篇
  2000年   94篇
  1999年   67篇
  1998年   63篇
  1997年   48篇
  1996年   47篇
  1995年   35篇
  1994年   27篇
  1993年   27篇
  1992年   29篇
  1991年   28篇
  1990年   18篇
  1989年   19篇
  1988年   22篇
  1987年   20篇
  1986年   19篇
  1985年   16篇
  1984年   15篇
  1983年   16篇
  1982年   18篇
  1981年   8篇
  1980年   9篇
  1979年   4篇
  1978年   4篇
  1977年   6篇
  1976年   2篇
  1975年   1篇
  1974年   2篇
  1973年   6篇
  1972年   3篇
排序方式: 共有3431条查询结果,搜索用时 62 毫秒
1.
脊髓髓内肿瘤的手术治疗   总被引:96,自引:12,他引:84  
目的:探讨各种病理类型的脊髓髓内肿瘤临床和影像学的鉴别诊断,肿瘤囊腔及其空洞的形成机理,脊髓前动脉在病理状态下的作用及各种肿瘤的手术切除技巧。方法:系统分析了经显微手术切除的104例(116个)髓内肿瘤,包括室管膜瘤,星形细胞瘤,血管网状细胞瘤等十余种病理类型的临床资料,并进行了动物脊髓血管闭塞模型的研究。结果:全组无手术死亡率,亦无手术致残者。绝大多数病人得到满意疗效,并保证了患者良好的术后存活质量。结论:对于绝大多数髓内肿瘤,显微外科手术治疗是目前最根本的治疗方法。强调早期治疗及对不同肿瘤采取相应的微创性手术技巧。对于那些疯狂侵润性生长的恶性肿瘤,要考虑一定剂量的常规放射治疗。  相似文献
2.
精神分裂症院内康复措施及其疗效的一年随访   总被引:95,自引:1,他引:94  
目的 探讨院内康复措施对精神分裂症患者的作用。方法 将 12 4例精神分裂症住院患者随机分为措施干预组和对照组 ,每组各 6 2例。在抗精神病药治疗的同时 ,对干预组施以小组工作制、院内职业康复的两种技能训练 ,共 10周。出院后随访 1年。用简明精神病评定量表 (BPRS)、住院病人护士观察量表 (NOSIE 30 )、社会功能缺陷筛选量表 (SDSS)和就业率等进行评估。结果  (1)与入组时比较 ,住院期间干预组NOSIE 30各因素的变化值从住院的第 2周开始至第 10周均优于对照组(均P <0 0 1) ,且增分和减分的幅度逐渐增大。 (2 )出院时点与随访最后时点评分差值的比较 ,干预组的SDSS分 [(4 0± 2 7)分 ]、NOSIE 30积极因素分 [(- 2 4 8± 4 9)分 ]和消极因素分 [(8 9± 3 6 )分 ]均显著优于对照组 [分别为 (- 3 9± 1 9)分、(5 2± 5 0 )分和 (- 19 5± 5 9)分 ;均P <0 0 1~P <0 0 0 1];(3)干预组的复发率 (10 %)、再住院率 (3%)和再就业率 (4 1%)皆优于对照组 (分别为 6 9%、5 6 %和 13%,P =0 0 0 0 )。结论 院内康复措施对控制精神分裂症患者的病情、提高社会功能和再就业率 ,以及降低复发率和再住院率具有重要的作用。  相似文献
3.
140例脑脓肿分析   总被引:39,自引:1,他引:38  
本文回顾性分析我院从1980~1991年常规应用CT后140例脑脓肿的诊治。最常见的病因为隐源性感染,多房、多发性及直径小于2cm的小脓肿发生率升高。最常见的需氧菌是金黄色葡萄球菌和变形杆菌,厌氧菌为消化链球菌和脆弱拟杆菌;多种细菌混合感染占29%。13例保守治疗者无1例死亡,反复穿刺、引流及脓肿切除术之间死亡率无显著性差异,总死亡率为7.1%;死亡率高低与入院时意识状态最为密切。  相似文献
4.
颅内动脉瘤3D-CTA诊断效能的临床研究   总被引:39,自引:8,他引:31  
目的 评价三维CT血管成像(3D—CTA)在外科治疗颅内动脉瘤中的诊断效能。方法 24例可疑动脉瘤患者行脑血管造影、3D—CTA、MRA和DSA检查。结果 本组共发现28个动脉瘤。21例病人有一个,2例有两个,1例有三个动脉瘤。3D—CTA发现瘤体呈球形为20个、椭圆形5个、分叶形3个。手术暴露的24个动脉瘤,其瘤体形态与3D—CTA发现完全吻合。动脉瘤颈平均直径为5.9mm,最小为1.6mm,最大为13.7mm。根据3D—CTA计算的动脉瘤颈结果与手术发现非常接近。3D—CTA对载瘤动脉和分枝动脉的形态描述明显优于脑血管造影、MRA和DSA。结论 3D—CTA在了解动脉瘤的三维结构和制定手术治疗方案有重要辅助作用。  相似文献
5.
自发性寰枢椎脱位(附155例报告)   总被引:36,自引:5,他引:31  
目的 探讨自发性寰枢椎脱位的病因、发病机理及诊治原因。方法 报告155例自发性寰枢椎脱位,根据影像学检查所见,分为三种类型。130例Ⅰ型和Ⅲ型脱位病人多经口腔切除齿状突行前路减压,再作后路枕颈植骨融合固定。25例Ⅱ型脱位病人试行头颅牵引,复位后作后路融合固定;不能复位者先经口腔切除部分C2椎体,再作后路融合固定。结果 128例平均随访6年8月,显效51例,有效48例,无变化16例,加重10例,死亡  相似文献
6.
The aim of this cross-sectional study was to quantify patients' personal beliefs about the necessity of their prescribed medication and their concerns about taking it and to assess relations between beliefs and reported adherence among 324 patients from four chronic illness groups (asthma, renal, cardiac, and oncology). The findings revealed considerable variation in reported adherence and beliefs about medicines within and between illness groups. Most patients (89%) believed that their prescribed medication was necessary for maintaining health. However, over a third had strong concerns about their medication based on beliefs about the dangers of dependence or long-term effects. Beliefs about medicines were related to reported adherence: higher necessity scores correlated with higher reported adherence (r=0.21, n=324, p<0.01) and higher concerns correlated with lower reported adherence (r=0.33, n=324, p<0.01). For 17% of the total sample, concerns scores exceeded necessity scores and these patients reported significantly lower adherence rates (t=-4.28, p<0.001). Stepwise multiple linear regression analysis showed that higher reported adherence rates were associated with higher necessity-concerns difference scores (beta=0.35, p<0.001), a diagnosis of asthma (beta= -0.31, p<0.001), a diagnosis of heart disease (beta=0.19, p<0.001), and age (beta=0.22, p<0.001). Gender, educational experience, or the number of prescribed medicines did not predict reported adherence. Medication beliefs were more powerful predictors of reported adherence than the clinical and sociodemographic factors, accounting for 19% of the explained variance in adherence. These data were consistent with the hypothesis that many patients engage in an implicit cost-benefit analysis in which beliefs about the necessity of their medication are weighed against concerns about the potential adverse effects of taking it and that these beliefs are related to medication adherence.  相似文献
7.
神经内镜手术并发症及防治   总被引:35,自引:8,他引:27  
目的 探讨与神经内镜应用有关的常见并发症和防治方法。方法 回顾分析1998年10月至2002年10月应用内镜手术并具备半年以上随访的病例,选取5个有代表性的病种共500例,疾病种类包括颅内表皮样囊肿、垂体瘤、脑积水、颅内囊肿、脑囊虫。手术方法包括单纯内镜手术、内镜辅助的显微外科、内镜下经单鼻孔垂体瘤切除术:结果 单纯内镜手术并发症为术中出血8/240例(3.3%);感染5/240例(2.1%);内镜辅助的显微外科手术中颅神经损伤2/110(1.8%)。三脑室底造瘘的病人中,一过性高热10.2%,一过性精神症状9.1%,头痛6.1%,脑膜炎l%。内镜下垂体瘤手术中,6.7%的病人有一过性脑脊液漏;0.8%有脑膜炎。结论 神经内镜手术的并发症发生率较低,并且多数是可以防治的。  相似文献
8.
Magnesium protects against neurological deficit after brain injury   总被引:33,自引:0,他引:33  
The biochemical factors that mediate secondary or delayed damage to the central nervous system (CNS) remain speculative. We have recently demonstrated that brain injury in rats causes a rapid decline in brain intracellular free magnesium (Mg2+) and total magnesium concentrations that is significantly correlated with the severity of injury. In order to further investigate the relationship between Mg2+ and brain injury, we examined the effect of Mg2+ treatment on posttraumatic neurological outcome following fluid-percussion brain injury (2.0 atm) in rats. Since administration of ATP-MgCl2 has been shown to be beneficial in a variety of models of organ ischemia, we also examined the efficacy of ATP-MgCl2 or ATP alone in the treatment of experimental brain injury. Animals treated with low (12.5 mumol) or high (125 mumol) dose MgCl2 at 30 min postinjury showed a significant dose-dependent improvement in neurological function when compared to saline-treated controls. Treatment with ATP-MgCl2 (12.5 mumol) or ATP alone (12.5 mumol) caused no significant improvement in chronic neurological outcome. MgCl2-treated animals showed no change in postinjury mean arterial blood pressure (MAP), whereas animals treated with either ATP-MgCl2 or ATP alone showed a transient but significant fall in MAP (P less than 0.01) during the drug-infusion period. Our results suggest that postinjury treatment with MgCl2 is effective in limiting the extent of neurological dysfunction following experimental traumatic brain injury in the rat.  相似文献
9.
Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its topographic possibilitiesellipsis while science is the compass that keeps us from getting lost. -R. T. Bartus, Simple Words for Complex Lives, (c) 1998 In the nearly 20 years since the cholinergic hypothesis was initially formulated, significant progress has been achieved. Initial palliative treatments for Alzheimer's disease (AD) have proven beneficial and have gained FDA approval, the use of animal models for studying AD and other neurodegenerative diseases has achieved wider acceptance, and important insight into the potential causes and pathogenic variables associated with various neurodegenerative diseases continues to increase. This paper reviews the current status of the cholinergic hypothesis in the context of continuing efforts to improve upon existing treatments for AD and explores the role that animal models might continue to play. Using the benefit of hindsight, particular emphasis is placed on an analysis of the approaches, strategies, and assumptions regarding animal models that proved useful in developing the initial treatments and those that did not. Additionally, contemporary issues of AD are discussed within the context of the cholinergic hypothesis, with particular attention given to how they may impact the further refinement of animal models, and the development of even more effective treatments. Finally, arguments are presented that, despite the deserved enthusiasm and optimism for identifying means of halting the pathogenesis of AD, a clear need for more effective palliative treatments will continue, long after successful pathogenic treatments are available. This review, therefore, focuses on issues and experiences intended to: (a) facilitate further development and use of animal models for AD and other neurodegenerative diseases, and (b) accelerate the identification of newer, even more effective treatments.  相似文献
10.
显微神经外科手术治疗痉挛型脑瘫738例临床观察   总被引:32,自引:19,他引:13  
目的探讨显微神经外科手术治疗痉挛型脑瘫的疗效。方法回顾分析2000年3月至2003年3月显微神经外科手术治疗的738例痉挛型脑瘫病例,根据病例的不同情况采用相应的选择性周围神经部分切断术,包括:胫神经、坐骨神经、肌皮神经、正中神经、颈段和腰骶段脊神经后根。结果全部病人平均随访19个月。98.6%病人术后立即感痉挛状态缓解,随访期间缓解率为89.5%。术后6周内运动功能改善率为75.0%,随访期间为87%。生活质量提高率在随访期间为90.2%。术后发生肢体感觉障碍199侧(21.7%),肌无力123侧(13.4%),随访期间均见好转。术后肢体痉挛状态不同程度复发83例(9.1%)。结论选择性周围神经部分切断术是治疗痉挛型脑瘫安全有效的手术方法。选择合适的病例、熟悉局部解剖、掌握显微手术技巧和术后坚持长期正规康复训练是保证疗效的关键。  相似文献
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号