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1.
目的 探讨易肇事肇祸严重精神障碍患者在村医全程督导服药管理下的效果.方法 在石家庄市随机选取2个县(区)作为试点,对登记在册的严重精神障碍患者进行筛查,采用社会功能缺陷量表(SDSS)、患者危险性评估表(参照《重性精神疾病管理治疗工作规范(2012年版)》危险性评估)分别在入组时以及干预后3,6,9,12个月时,对患者的社会功能和危险性进行评定,并比较两组患者的再入院率.结果 干预9个月后干预组的SDSS评分明显优于对照组,干预6个月后干预组的危险性等级明显低于对照组,两组差异均有统计学意义(P<0.01);干预其间,干预组中12例次(12.12%)再次住院接受治疗,对照组有65例次(66.33%),两组差异有统计学意义(χ2=60.777,P<0.01).结论 对易肇事肇祸严重精神障碍患者进行全程督导服药管理能够改善患者的社会功能,降低患者的危险性分级,减少对家庭社会的影响,降低患者的再住院率.  相似文献
2.
目的:了解武汉市武昌区重性精神疾病患者的现状与相关因素之间的关系,为社区有效管理提供依据。方法资料来源于国家重性精神疾病网络管理系统,对武昌区3358例重性精神疾病患者的相关数据进行描述性分析,对患者病程及疾病类型的影响因素进行 Logistic 回归分析。结果武昌区网络管理的重性精神疾病患者中单身者占59.38%,初中及以下文化程度者占60.18%,家庭经济状况贫困者占43.33%,无业或下岗者占60.76%。Logistic回归分析发现,经济状况(OR =0.896)、文化程度(OR =1.430)会影响病程;文化程度(OR =0.549)、经济状况(OR =1.212)、婚姻(OR =1.183)、职业(OR =1.215)会影响精神疾病类型。结论应将精神分裂症、精神发育迟滞(伴发精神障碍)作为管理重点,尤其是对未服药及依从性差的患者。  相似文献
3.
Objective. In a previous multisite comparative study of spiritual and religious coping (S/R) among outpatients with schizophrenia; S/R were adaptive for 80% of patients; harmful for 13%; and marginal for 7%. This importance was underestimated by clinicians. We created an interfaith therapeutic group to address such topics. The aim of the study is to assess patients’ wish to address S/R issues in their psychiatric care. Method. Psychiatrists asked consecutive outpatients about their wish; with who they shared S/R concerns; and their interest to enroll in the “Spiritual and Recovery Group”. Results. Among the 147 patients included less than half shared their spiritual concerns with other people. A quarter wished to address S/R issues in their care; 24/147 already shared those issues with a religious professional; half of them wished also to share them with their psychiatrist. Among the 21 patients who participated in an in-depth spiritual assessment 16 patients were directed to the S/R group and 5 patients were directed to groups addressing other therapeutic objectives. Conclusion. For one patient out of ten, S/R issues were of a clinical significance warranting integration into psychiatric treatment. This study shows that patients’ views are in accordance with former research, putting forward psychiatrists’ stance on this issue.  相似文献
4.
目的了解佛山市顺德区重性精神疾病患者的肇事肇祸等情况。方法对登记在册的4107例重性精神疾病患者进行一般信息统计和基础情况调查,评估其危险性,了解其肇事肇祸情况。结果4107例重性精神疾病患者中,肇事肇祸患者共962例(23%),肇事肇祸患者以精神分裂症(62%)最多见,并且具有男性(63.7%)为多、未婚和丧偶较多、经济状况较差、服药依从性差和阳性家族史较多的特点。结论要重视重性精神疾病患者的药物治疗,并建立有效的社区干预模式。  相似文献
5.
目的:对山东日照地区重性精神疾病患者管理治疗状况和肇事肇祸情况进行调查分析。方法:对日照市城乡部分登记在册的重性精神疾病患者进行疾病分类管理并对肇事肇祸情况进行危险性评估。结果:重性精神疾病患者中未治疗的患者占26.34%、门诊治疗的患者占34.31%,住院治疗的患者占39.35%。患者中肇事肇祸发生率为82.37%,其中精神分裂症患者肇事肇祸最多。危险性评估为高风险患者占53.30%。结论:重性精神疾病患者治疗不足,肇事肇祸发生多,应该加强这一特殊人群的管理和治疗。  相似文献
6.
目的:了解南宁市兴宁区重性精神疾病患者肇事肇祸情况及危险因素。方法:对登记在册的兴宁区712例重性精神疾病患者进行危险性评估,了解其有无肇事肇祸情况。结果:712例重性精神疾病患者中有肇事肇祸患者148例,占20.79%,其中精神分裂症患者中最多,占20.96%;肇事肇祸的发生与患者的性别、婚姻、家族史、服药依从性等原因有关。结论:需要针对高危的社区重性精神疾病患者加强监管和治疗。  相似文献
7.

Objective

Elevated levels of inflammation are reported in bipolar disorders (BP), but how this relates to affective symptoms is unclear. We aimed to determine if immune markers that consistently have been reported elevated in BP were associated with depressive and manic symptoms, and if this was specific for BP.

Methods

From a catchment area, 112 BP patients were included together with 153 schizophrenia (SCZ) patients and 239 healthy controls. Depression and mania were assessed and the patients were grouped into depressed, neutral, and elevated mood. We measured the immune markers tumor necrosis factor receptor 1 (sTNF-R1), interleukin 1 receptor antagonist (IL-1Ra), interleukin 6 (IL-6), high sensitive C-reactive protein (hsCRP), osteoprotegerin (OPG) and von Willebrand factor (vWf) which have been found increased in severe mental disorders.

Results

In BP all inflammatory markers were lowest in depressed state, with significant group differences after control for confounders with respect to TNF-R1 (p = 0.04), IL-1Ra (p = 0.02), OPG (p = 0.004) and IL-6 (p = 0.005). STNF-R1 was positively correlated with the item elevated mood (p = 0.02) whereas sad mood was negatively correlated with OPG (p = 0.0003), IL-1Ra (p = 0.001) and IL-6 (p = 0.006). Compared to controls the neutral mood group had significantly higher levels of OPG (p = 0.0003) and IL-6 (p = 0.005), and the elevated mood group had higher levels of TNF-R1 (p = 0.000005) and vWf (p = 0.002). There were no significant associations between affective states orsymptoms in SCZ.

Conclusions

The current associations between inflammatory markers and affective symptomatology in BP and not SCZ suggest that immune related mechanisms are associated with core psychopathology of BP.  相似文献
8.

Objective

Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is documented in bipolar disorder and schizophrenia, but the mechanism is unclear; recently, increased activity of cortisol metabolizing enzymes was indicated in these disorders. We investigated whether five genes involved in cortisol metabolism were associated with altered activity of cortisol metabolizing enzymes in bipolar disorder (BD) and schizophrenia spectrum disorders (SCZ).

Methods

A case–control sample of subjects with BD (N = 213), SCZ (N = 274) and healthy controls (N = 370) from Oslo, Norway, were included and genotyped from 2003 to 2008. A sub-sample (healthy controls: N = 151; SCZ: N = 40; BD: N = 39) had estimated enzyme activities based on measurements of urinary free cortisol, urinary free cortisone and metabolites. A total of 102 single nucleotide polymorphisms (SNPs) in the SRD5A1, SRD5A2, AKR1D1, HSD11B1 and HSD11B2 genes were genotyped, and significant SNPs analyzed in the sub-sample.

Results

There was a significant association of rs6732223 in SRD5A2 (5α-reductase) with SCZ (p = 0.0043, Bonferroni corrected p = 0.030, T risk allele). There was a significantly increased 5α-reductase activity associated with rs6732223 (T allele) within the SCZ group (p = 0.011).

Conclusions

The present data suggest an interaction between SCZ and SRD5A2 variants coding for the enzyme 5α-reductase, giving rise to increased 5α-reductase activity in SCZ. The findings may have implications for cortisol metabolizing enzymes as possible drug targets.  相似文献
9.
目的:了解农村重性精神疾病患者肇事肇祸情况。方法:从已登记的1427例农村重性精神疾病患者中调查有无肇事肇祸情况。结果:1427例中有肇事肇祸患者308例(21.6%),其中以精神分裂症最多1067例(74.8%)。肇事肇祸的发生率与患者的性别、文化程度、诊断、监护人、病程、住院次数和服药依从性等有关。结论:对农村重性精神疾病患者的监护和治疗工作应引起充分重视。  相似文献
10.
Background:  Alterations in the inflammatory system have been associated with schizophrenia and major depression, while bipolar disorder has been less studied. Most previous studies examined small samples, and the literature is inconsistent with regard to specific underlying immune mechanisms. In the present study, we examined markers representing different inflammatory pathways, and the aim was to investigate whether the levels of inflammatory parameters in a representative sample of bipolar disorder and schizophrenia are elevated compared to healthy controls, and to investigate whether the inflammatory profile is different between the groups.
Methods:  Plasma levels of soluble tumor necrosis factor receptor 1 (sTNF-R1), interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), high-sensitivity CRP (hs-CRP), soluble CD40L ligand (sCD40L), and von Willebrand factor (vWf) were measured with ELISA techniques in a catchment area based sample of consecutively referred patients with severe mental disorders [N = 311, comprising bipolar disorder (n = 125) and schizophrenia (n = 186)] and in healthy volunteers (n = 244).
Results:  Plasma levels of sTNF-R1 and vWf were statistically significantly increased in both bipolar disorder and schizophrenia compared to controls (p < 0.00001), and were also increased in unmedicated patients, but there were no major differences between the two diagnostic groups. Controlling for age, gender, ethnicity, cardiovascular disorders, kidney and liver function, and other confounders did not affect the results. There were no differences in other inflammation factors between the groups.
Conclusion:  The present results indicate specific alterations of endothelium-related inflammation processes in both bipolar disorder and schizophrenia.  相似文献
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