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摘要:目的 基于光激化学发光技术平台初步建立血清催乳素(PRL)的分析方法,并评估其性能指标。方法 将发光纳米微球和生物素分别标记于一对人PRL单抗,两者与血清中待检泌乳素、链霉亲和素标记的感光微球(通用感光溶液)在均相条件下形成双抗体夹心的检测体系,并对该检测体系的性能指标和相关性进行评价。结果 本方法的批内及批间精密度(变异系数)分别为4.60%和5.25%;检测范围为2.48~ 4240 μIU/ml;加标回收试验的回收率在96.25%-97.16%;胆红素<20 mg/dL、血红蛋白<200 mg/dL、甘油三酯<3000 mg/dL时,均无干扰现象发生;且该方法与贝克曼Unicel Dxi 800 Access 2酶促化学发光免疫系统分析法具有良好的相关性。 结论 光激化学发光法检测血清PRL的方法具有良好的分析性能,可满足临床诊断需求。 相似文献
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目的:探讨子宫内膜异位症不孕患者与非子宫内膜异位症不孕患者血清卵泡刺激素、黄体生成素、雌二醇、睾酮、促甲状腺激素及泌乳素的差异。方法:选取2015~2016年907例子宫内膜异位症不孕患者(观察组),与1579例非子宫内膜异位症的不孕患者(对照组),对比分析两组患者激素水平。结果:两组卵泡刺激素、黄体生成素、雌二醇、睾酮、促甲状腺激素水平差异无统计学意义。观察组泌乳素水平[(17.8±8.8)ng/mL vs.(16.8±8.2)ng/mL]高于对照组,差异有统计学意义(P=0.005)。子宫内膜异位症卵巢型患者血清泌乳素水平为(17.1±7.1)ng/mL,腹膜型为(18.9±11.0)ng/mL,腹膜型高于卵巢型,差异有统计学意义(P=0.009)。结论:子宫内膜异位症不孕患者泌乳素水平升高,针对泌乳素的机制研究与干预可能有助于了解不孕症的发生机制、提高临床诊治效果。 相似文献
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It has been well recognized that prolactin (PRL), a pleiotropic hormone, has many functions in the brain, such as maternal behavior, neurogenesis, and neuronal plasticity, among others. Recently, it has been reported to have a significant role in neuroprotection against excitotoxicity. Glutamate excitotoxicity is a common alteration in many neurological and neurodegenerative diseases, leading to neuronal death. In this sense, several efforts have been made to decrease the progression of these pathologies. Despite various reports of PRL’s neuroprotective effect against excitotoxicity, the signaling pathways that underlie this mechanism remain unclear. This review aims to describe the most recent and relevant studies on the molecular signaling pathways, particularly, PI3K/AKT, NF-κB, and JAK2/STAT5, which are currently under investigation and might be implicated in the molecular mechanisms that explain the PRL effects against excitotoxicity and neuroprotection. Remarkable neuroprotective effects of PRL might be useful in the treatment of some neurological diseases. 相似文献
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目的 探讨帕利哌酮缓释片与阿立哌唑治疗青年女性首发精神分裂症的疗效及对社会功能的影响。方法 选取我院2017年5月~2019年2月收治的72例首发精神分裂症青年女性患者,按随机数字表法分为两组,A组35例,B组37例,A组给予帕利哌酮,B组给予阿立哌唑,两组均连续治疗8周。观察两组患者治疗前、后血清催乳素、糖脂代谢、社会功能指标,并评定疗效。结果 治疗第4周,A组PANSS评分显著低于B组(P<0.05);治疗第4周、第8周,两组血清PRL,与治疗前相比无显著差异(P>0.05);治疗第8周,两组脂代谢指标TG水平,均显著高于治疗前(P<0.05);B组糖代谢指标GLU水平,显著高于治疗前(P<0.05);治疗第4周、第8周,A组PSP评分显著高于同期B组(P<0.05);治疗期间,A组体重增加、镇静不良反应的发生率均显著高于B组(P<0.05);B组失眠、焦虑不良反应的发生率显著高于A组(P<0.05);A组总有效率80.00%,显著高于B组62.16%(P<0.05)。结论 帕利哌酮与阿立哌唑治疗青年女性首发精神分裂症对血清催乳素无显著影响,对脂代谢均产生一定的影响,且阿立哌唑还会影响糖代谢水平,引起失眠、焦虑等不良反应,帕利哌酮的社会功能恢复力高于阿立哌唑,起效快于阿立哌唑,但8周后疗效相当,且会引起体重增加、镇静等不良反应。 相似文献
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Mustafa Kadihasanoglu Semih Aktas Emre Yardimci Hale Aral Ates Kadioglu 《The journal of sexual medicine》2021,18(2):256-264
BackgroundSARS-CoV-2 which causes coronavirus disease 2019 (COVID-19) binds to angiotensin-converting enyzme 2 (ACE2) and enters the host cell. ACE2 protein is expressed highly in the testis.AimThe aim of this study was to compare male reproductive hormones such as total testosterone (TT), luteinizing hormone (LH), follicular stimulant hormone (FSH), and prolactin between patients with COVID-19, age-matched cases with non–COVID-19 respiratory tract infection, and age-matched controls.MethodsThis was a prospective cohort study and included 262 men aged between 20 and 65 years. The study comprised 3 groups including patients with COVID-19 (n = 89), cases with non–COVID-19 respiratory tract infection (n = 30), and age-matched controls (n = 143). All cases were evaluated using TT, LH, FSH, and prolactin. Correlations between TT and clinical parameters of patient groups were investigated using Pearson's correlation test.OutcomesThe primary outcome of the study was detection of the difference of TT, FSH, LH, and prolactin levels between the groups. Secondary outcome was to correlate TT and hospitalization time and oxygen saturation on hospital admission (SpO2) of patients.ResultsThe mean age of study groups was 49.9 ± 12.5 years, 52.7 ± 9.6 years, and 50 ± 7.8 years, respectively (P = .06). Serum TT levels was median 185.52 ng/dL in patients with COVID-19, median 288.67 ng/dL in patients with non–COVID-19 respiratory tract infection and median 332 ng/dL in control cases, (P < .0001). The proportion of patients with testosterone deficiency in group 1, group 2, and group 3 was 74.2%, 53.3%, and 37.8%, respectively (P < .0001). Serum LH levels (P = 0.0003) and serum prolactin levels (P = .0007) were higher in patients with COVID-19 and patients with non–COVID-19 respiratory tract infection than control cases. Correlation analysis revealed significant negative correlation between serum TT levels and hospitalization time of patients with COVID-19 (r = –0.45, P < .0001). In addition, a significant positive correlation was observed between SpO2 and serum TT levels in patients with COVID-19 ( r = 0.32, P = .0028).Clinical ImplicationsPhysicians may consider to evaluate male patients with COVID-19 for concomitant androgen deficiency.Strengths & LimitationsStrengths include the evidence about the alteration of male reproductive hormones under COVID-19. Limitations include the analysis limited to one general hospital, only a single measurement of TT was available, free and bioavailable testosterone levels were not evaluated.ConclusionThis study demonstrates COVID-19 is associated with decreased level of TT and increased level of LH and prolactin. More serious COVID-19 causes more reduction in TT levels and prolongs hospitalization period.Kadihasanoglu M, Aktas S, Yardimci E, et al. SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study. J Sex Med 2021;18:256–264. 相似文献
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目的探讨女性精神分裂症患者泌乳素、雌二醇水平及神经功能改变。方法选取100例女性首发精神分裂症患者作为研究组,选取同期在本院体检的100例正常女性作为对照组。检测并比较两组研究对象的血清泌乳素、雌二醇水平及美国国立卫生研究院卒中量表(NIHSS)评分。结果研究组患者的泌乳素水平(29.65±7.51)μg/L明显高于对照组的(20.02±7.45)μg/L,雌二醇水平(52.38±7.81)pmol/L明显低于对照组的(101.42±6.11)pmol/L,差异具有统计学意义(P<0.05)。研究组患者的NIHSS评分(8.47±2.33)分明显高于对照组的(0.15±0.03)分,差异具有统计学意义(P<0.05)。结论女性精神分裂症患者泌乳素明显高于正常体检者,雌二醇水平明显低于正常体检者,这与神经功能紊乱之间存在密切关系。泌乳素和雌二醇水平的变化与神经功能紊乱在女性精神分裂症患者的临床诊断和监控中有着重要的参考意义。 相似文献
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