首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8192篇
  免费   514篇
  国内免费   232篇
耳鼻咽喉   311篇
儿科学   800篇
妇产科学   181篇
基础医学   365篇
口腔科学   133篇
临床医学   1472篇
内科学   241篇
皮肤病学   31篇
神经病学   1880篇
特种医学   299篇
外科学   850篇
综合类   660篇
预防医学   554篇
眼科学   352篇
药学   366篇
  3篇
中国医学   373篇
肿瘤学   67篇
  2023年   113篇
  2022年   216篇
  2021年   338篇
  2020年   355篇
  2019年   325篇
  2018年   323篇
  2017年   351篇
  2016年   344篇
  2015年   276篇
  2014年   569篇
  2013年   895篇
  2012年   460篇
  2011年   493篇
  2010年   395篇
  2009年   337篇
  2008年   361篇
  2007年   345篇
  2006年   310篇
  2005年   252篇
  2004年   227篇
  2003年   171篇
  2002年   170篇
  2001年   169篇
  2000年   136篇
  1999年   130篇
  1998年   83篇
  1997年   84篇
  1996年   76篇
  1995年   59篇
  1994年   70篇
  1993年   53篇
  1992年   47篇
  1991年   33篇
  1990年   31篇
  1989年   38篇
  1988年   26篇
  1987年   24篇
  1986年   22篇
  1985年   35篇
  1984年   24篇
  1983年   19篇
  1982年   26篇
  1981年   21篇
  1980年   13篇
  1979年   15篇
  1978年   15篇
  1977年   14篇
  1976年   10篇
  1975年   7篇
  1973年   7篇
排序方式: 共有8938条查询结果,搜索用时 15 毫秒
1.
ObjectivesSystematic review of the scientific literature dedicated to treatment modalities and results for aural tuberculosis published since the start of the 21st century.Material and methodsSearch of the Medline, Cochrane and Embase databases for the period 2000 - 2020. Selection of articles in English, French and Spanish devoted to clinical cases and series documenting treatment of auricular tuberculosis. Extraction of data on pre-established files documenting treatment modalities and results. Reading of articles by two authors. Analysis performed according to SWiM guidelines, evaluating cure, tuberculosis-related death, treatment-related complications, improvement in facial palsy, and hearing sequelae rates.ResultsOne hundred and twenty eight articles: 118 case reports (159 patients) and 10 cohorts (177 patients) from 42 countries were analyzed. Female/male sex ratio was 1.2 with ages ranging from 1 month to 87 years. Medical treatment consisted in 5 to 24 months’ antitubercular antibiotic treatment using 2 to 8 antibiotics. Mastoidectomy, tympanoplasty and facial nerve decompression were associated to medical treatment in 64.7%, 17.4% and 6.2% of cases, respectively. Overall rates of cure, death, treatment-related complications, facial sequelae and hearing sequelae were 96.8%, 2%, 9.5%, 35.8% and 75.5%. In case reports, BCG vaccination did not appear to protect against facial palsy and severe intracranial complications (P > 0.6). There was no significant correlation (P > 0.3) between death and the clinical variables tested, and facial nerve decompression did not appear to influence outcome for facial function (P = 0.4).ConclusionMedical treatment is very effective but not without risk of death, complications and sequelae. It is the same as for pulmonary tuberculosis. Indications for and benefit of major auricular surgery during medical treatment deserve further studies.  相似文献   
2.
BackgroundGait classification systems (GCS) may enable clinicians to differentiate gait patterns into clinically significant categories that assist in clinical decision-making and assessment of outcomes. Davids and Bagley in 2014 [1] described a GCS for children with cerebral palsy (GCS-CP). The purpose of our study was to use the GCS-CP for the first time on a sample of patients with CP and to evaluate the reliability and utility of the classification system.MethodsThe gait of 131 children with CP was retrospectively reviewed and classified according to Davids and Bagley’s classification using two-dimensional (2D) video and three-dimensional (3D) lower limb kinematics and kinetics. Gross Motor Function Classification System (GMFCS) levels were determined, and the Gait Profile Scores (GPS) calculated to characterize the sample concerning gait classification. The comparison between the groups was performed using the Kruskal-Wallis test with respect to the non-normal distribution of the data. The intrarater and interrater reliability was determined using the Kappa index (k) statistics with 95% CI.ResultsAll GCS-CP groups were represented within the evaluated sample. Of the 131 cases evaluated, 127 (96.95%) were able to be classified with respect to sagittal plane stance phase gait deviations. All patients in the sample were able to be classified with respect to sagittal plane swing phase and transverse plane gait deviations. The interrater reliability was 0.596 and 0.485 for the first and second levels of the classification, respectively, according to the Fleiss’s Kappa statistics. Intrarater reliability was 0.776 and 0.714 for the raters one and two, respectively, according to the Cohen’s Kappa statistics.SignificanceThe GCS-CP exhibited clinical utility, successfully classifying almost all subjects with CP in two planes, based upon kinematic and kinetic data. The classification is valid and has moderate interrater and moderate to substantial intrarater reliability.  相似文献   
3.
BackgroundThe Fullerton Advanced Balance Scale (FAB) is a multi-item balance assessment test designed to measure balance in relatively higher functioning individuals. The aim of this study was to examine the reliability and validity of the Turkish version of the FAB (FAB-T) in children with cerebral palsy (CP).Research questionIs the Turkish version of the Fullerton Advance Balance Scale valid and reliable in determining balance problems in children with cerebral palsy and determining the underlying cause of this condition?MethodsForty-six children with CP participated in this study. Rasch analysis was used to investigate item adherence. Internal consistency of the FAB-T was established using Cronbach's alpha coefficient. Test-retest reliability was also evaluated. In addition, to assess concurrent validity, FAB-T scores were compared with the Pediatric Balance Scale (PBS) using the Spearman correlation coefficient.ResultsThe FAB-T showed satisfactory internal consistency (Cronbach's alpha value=0.94) and excellent test-retest reliability (ICC=0.99). The FAB and the PBS exhibited concurrent positive validity (r = 0.913; p < 0.001). All items of the FAB-T were found to fit the Rasch Model (Chi-square 16.01(df=20), p = 0.716).SignificanceThe FAB-T is a reliable and valid tool that can be used to measure balance skills and to identify the source of the problem in children with CP.  相似文献   
4.
Juvenile Idiopathic Arthritis (JIA) is a multi-factorial disease influenced both by environmental and genetic factors. Progressive pseudorheumatoid dysplasia (PPD) is a rare autosomal recessive genetic disorder affecting multiple joints, mimicking JIA. Aim of the work: to reveal the frequency of HLA-DR types among the studied patients and to correlate the different allele variations clinically. Patients and methods: Thirty JIA patients, in addition to 15 molecularly diagnosed PPD patients were subjected to full history taking and clinical examination. HLA-DRB1 typing was performed to 24/30 JIA and 12/15 PPD cases and thirty healthy age and sex matched children who were included as a control group. Results: The JIA patients were 22 females and 8 males with mean age of 15.8 ± 1.96 years and disease duration 5.3 ± 4.4 years. PPD patients were 8 males and 7 females with mean age of 8.7 ± 3.06 years and disease duration 3.95 ± 2.68 years. A significant frequency of HLA-DRB 04 (p = 0.049) among JIA patients was present in comparison to the controls (OR = 2.81, CI:1.02–7.75), other risky alleles were HLA-DRB 10, 13 and 15. However, HLA-DRB 01, 03, 07, 11 and 14 were found to be protective. HLA-DRB 01, 04, 10 and 13 were found to be risky alleles in PPD. However, HLA 03, 07, 11 and 15 were found to be protective alleles among PPD patients. Conclusion: HLA-DRB 04 was found in a higher frequency in JIA patients with a significant difference in comparison to the controls, denoting that it may play a role in the genetic pathogenesis of JIA.  相似文献   
5.
目的探究丁苯酞+依达拉奉治疗进展性脑梗死(PCI)的临床效果。方法102例PCI患者,以计算机抽号方式随机分为B组和A组,各51例。B组采用依达拉奉治疗,A组采用丁苯酞+依达拉奉联合治疗。比较两组临床效果、用药不良反应发生率、血液流变学指标、治疗前及治疗后1、2周的美国国立卫生研究院卒中量表(NIHSS)评分。结果A组治疗总有效率90.20%高于B组的68.63%,差异有统计学意义(P<0.05)。A组的用药不良反应发生率9.80%(5/51)与B组的7.84%(4/51)比较,差异无统计学意义(P>0.05)。A组患者的纤维蛋白原、全血粘度、血小板聚集率分别为(2.72±1.08)g/L、(1.02±0.02)mPa·s、(52.33±7.54)%,均低于B组的(3.35±1.11)g/L、(1.18±0.08)mPa·s、(63.65±6.67)%,差异有统计学意义(P<0.05)。治疗后1、2周,A组NIHSS评分均低于B组,差异有统计学意义(P<0.05)。结论在PCI患者治疗中,采用丁苯酞+依达拉奉联合用药方案的临床效果显著,能减少患者神经功能损伤,并改善血液流变学,促进康复,且用药不良反应少,安全性高,值得在临床上推广应用。  相似文献   
6.
目的对脑瘫患儿发生癫痫持续状态的急救护理方法和效果进行探讨。方法选择2018年4月—2018年9月在医院收治的50例脑瘫发生癫痫持续状态的患儿作为对照组,对其实施常规急救护理,同时选择2018年10月—2019年3月在医院收治的50例脑瘫发生癫痫持续状态的患儿作为观察组,对其实施强化急救护理,对比两组护理满意度、生命体征评分、护理有效率。结果观察组的总体满意率、护理有效率、生命体征评分均优于对照组,两组差异明显,有统计学意义,P<0.05。结论对脑瘫发生癫痫持续状态的患儿实施强化急救护理能够提升治护效果,提高患儿家长满意度,更好的改善患儿生命体征。  相似文献   
7.
目的:探讨作业治疗对不随意运动型脑瘫患儿手眼协调能力的临床疗效。方法:选取2017年5月~2018年9月在广州中医药大学附属南海妇产儿童医院儿童康复科就诊的不随意运动型脑瘫患儿30例,进行作业治疗手眼协调训练,采用Peabody精细运动发育量表(PDMS-FM)及FMFM(手眼协调E项)评定临床疗效。结果:患儿FMQ评分、FMFM(E区)评分随治疗时间推移呈逐渐增加趋势,第二次评估与第一次评估比较有统计学意义(P<0.05),第三次评估和第二次评估有统计学意义(P<0.01)。结论:作业治疗手眼协调训练对不随意运动型脑瘫精细运动及手技巧有明显改善作用。  相似文献   
8.
9.
10.
AimTo assess the gait and cognitive performances of children with cerebral palsy (CP) during dual tasks (DT) in comparison to typically developing (TD) children.MethodThis prospective, observational, case-control study included 18 children with CP (7 girls, 11 boys; median age 12 [10:13] years and 19 controls (9 girls, 10 boys; median age 12 [10:13y6mo] years). Performances were recorded during a simple walking task, 5 DT (walking + cognitive tasks with increasing cognitive load), and 5 simple cognitive tasks (while sitting). Gait parameters were computed using an optoelectronic system during walking tasks. Six parameters were selected for analysis by a principal component analysis. Cognitive performance was measured for each cognitive task. The dual-task cost (DTC) was calculated for each DT.ResultsGait performance decreased in both groups as DT cognitive load increased (e.g., walking speed normalized by leg length, in simple task: 1.25 [1.15:1.46] s−1 for CP, 1.53 [1.38:1.62] s−1 for TD; DT with highest load: 0.64 [0.53:0.80] s−1 for CP, 0.95 [0.75:1.08] s−1 for TD). The CP group performed significantly worse than TD group in every task (including the simple task), but DTC were similar in both groups. A task effect was found for the majority of the gait parameters.InterpretationThe reduced gait performance induced by DT may generate underestimated difficulties for children with CP in daily-life situations, where DT are common. This should be considered in clinical assessments.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号