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1.
抗精神病药致血糖改变与体重体脂指标关系   总被引:22,自引:4,他引:18  
目的:分析首次治疗的精神分裂症患者抗精神病药(APS)急性期治疗期间血糖改变及其与体重体脂指标间的关系方法:测定46例患者(男27例,女19例)APS单药治疗10周前后空腹血糖和餐后2h血糖;观察治疗前后体重指数(BMI)和腰臀比率(WHR),并采用磁共振测定其中40例患者治疗前后腹部脂肪分布结果:患者治疗10周后餐后2h血糖明显增高,葡萄糖耐量低减(IGT)发生率增加。治疗前餐后2h血糖水平与体重体脂指标呈正相关;治疗10周后,餐后2h血糖水平与体重体脂指标无相关。结论:APS急性期治疗可致精神分裂症患者血糖异常;血糖水平改变与体重增加及体脂沉积有关。  相似文献
2.
代谢综合征是脑卒中的危险因素   总被引:7,自引:0,他引:7  
目的初步探讨代谢综合征与初发脑卒中的关系。方法选择905例初发脑卒中患者和500例正常对照,计算各组代谢综合征的现患率。测定纤维蛋白(原)、C-反应蛋白等指标。结果初发卒中患者代谢综合征的现患率是对照组的3倍;伴代谢综合征的脑卒中患者中,缺血性卒中(80.75%)所占比例显著超过出血性卒中,CRP和FIB(均P〈0.05)均明显高于同组不伴MS的患者及对照组。结论代谢综合征是脑卒中的危险因素之一,其机制可能与凝血纤溶系统、炎症等方面有关。  相似文献
3.
精神分裂症患者伴发代谢综合征的患病率调查   总被引:6,自引:1,他引:5  
目的调查国内精神分裂症患者中代谢综合征的患病率及分析可能的相关影响因素。方法对住院的精神分裂症患者进行问卷调查和实验室测定,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综合征标准。结果符合入组条件者共完成602例。精神分裂症患者中代谢综合征患病率为35.5%。与代谢综合征患病风险相关的危险因素包括年龄、性别、抗精神病药物种类及精神分裂症的病程(P〈0.05)。Logistic回归分析结果显示,女性精神分裂症患者罹患代谢综合征的相对危险度明显高于男性。年龄的相对危险度为12.27(95%CI2.238-32.557)。抗精神病药物种类与代谢综合征的患病风险有关(P=0.047〈0.05)。结论与普通人群相比,精神分裂症患者具有较高的代谢综合征发病风险,可能的危险因素包括女性、高龄、病程长及服用氯氮平药物等。  相似文献
4.
OBJECTIVE: This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians. METHODS: Data were collected from participants entering the Bipolar Disorder Center for Pennsylvanians protocol between 2003 and 2004. The study focused on the presence of the metabolic syndrome, as defined by the National Cholesterol Education Program Expert Panel on Detection, Evaluation And Treatment of High Blood Cholesterol in Adults (NCEP ATP III). RESULTS: Thirty percent of the sample met the NCEP ATP III criterion for the metabolic syndrome, 49% met the criterion for abdominal obesity, 41% met the criterion for hypertriglyceridemia, 48% met the criterion for hypertriglyceridemia or were on a cholesterol-lowering medication, 23% met the criterion for low high-density lipoprotein cholesterol, 39% met the criterion for hypertension and 8% met the criterion for high fasting glucose or antidiabetic medication use. Patients with the metabolic syndrome and patients endorsing the obesity criterion were more likely (p = 0.05 and p = 0.004, respectively) to report a lifetime history of suicide attempt/s. CONCLUSIONS: The prevalence of the metabolic syndrome in patients with bipolar disorder is alarmingly high, as it is for the general population. The prevalence of obesity is even higher than the already very high prevalence that has been estimated for the US general population. Our findings are a reason for concern, considering the difficulty in implementing prevention and treatment programs in the bipolar population. We strongly support the development and testing of interventions specifically designed for preventing and treating the metabolic syndrome and its components in patients with bipolar disorder.  相似文献
5.
Paraventricular nucleus, stress response, and cardiovascular disease   总被引:4,自引:0,他引:4  
Abstract The paraventricular nucleus of the hypothalamus (PVN) is a complex effector structure that initiates endocrine and autonomic responses to stress. It receives inputs from visceral receptors, circulating hormones such as angiotensin II, and limbic circuits and contains neurons that release vasopressin, activate the adrenocortical axis, and activate preganglionic sympathetic or parasympathetic outflows. The neurochemical control of the different subgroups of PVN neurons is complex. The PVN has been implicated in the pathophysiology of congestive heart failure and the metabolic syndrome.  相似文献
6.
To elucidate the relationship between metabolic syndrome (MetS) and cerebrovascular stenosis, we performed comparative studies of MetS and its components between ischemic stroke patients with intra- and extracranial atherostenosis. We evaluated 378 acute ischemic stroke patients who underwent brain magnetic resonance (MR) imaging and MR angiography. Stenosis was diagnosed in cases showing a degree of luminal narrowing of ≥ 50%. The stroke subtypes were categorized as large artery atherosclerosis (LAA), small artery occlusion (SAO), cardioembolism (CE), and stroke of undetermined etiology (SUE). MetS was defined using the criteria of the Adult Treatment Panel III. The mean carotid intimal medial thickness values showed increased tendency as the number of MetS components increased ( P  < 0.001). Regardless of stroke subtype, the MetS (+) group showed an increasing tendency toward stenosis (LAA, SAO, all P  < 0.001; CE, P  = 0.001; SUE, P  = 0.077). MetS was independently associated with intracranial atherosclerosis (odds ratio, 3.58; 95% CI, 2.28–5.63), which was prominent with more severe MetS components after adjustment for other risk factors ( P  < 0.001). Amongst the component conditions, elevated blood pressure, increased blood glucose/hyperglycemia, and abdominal obesity were dominantly associated with stenosis (all P  < 0.001). Modifications of the individual MetS components need to be considered for stroke prevention because of intracranial atherogenic progression.  相似文献
7.
住院精神分裂症患者代谢综合征的患病率及相关因素   总被引:3,自引:0,他引:3  
目的 了解住院精神分裂症患者代谢综合征的患病率及其相关因素.方法 对上海市精神卫生中心分部住院的精神分裂症患者作调查,测定其代谢指标,采用世界糖尿病联盟(IDF)全球统一标准定义代谢综合征.结果 共入组483人,其中男性272人(56.3%),女性211人(43.7%),平均年龄(53±10)岁(19~82岁).住院精神分裂症患者代谢综合征的患病率为43.9%(213/483),女性的患病率(118/211,55.9%)高于男性的(94/272,36.4%)(χ2=22.0,P<0.05).患病率随年龄增加而增加.大于41岁的患者中女性的代谢综合征患病率均高于男性.Logistic回归发现代谢综合征与性别有关.结论 在精神分裂症患者尤其女性患者中存在较多的代谢综合征,疾病早期即应予以关注.  相似文献
8.
长期住院治疗的精神分裂症患者代谢综合征风险研究   总被引:3,自引:0,他引:3  
目的调查长期服用抗精神病药的精神分裂症患者在糖脂代谢相关变量的情况及相关风险的评估,以便为进一步研究抗精神病药与代谢综合征发生的因果关系提供初步的调查线索。方法以上海市精神卫生中心住院诊断为精神分裂症且持续服用治疗剂量抗精神病药至少6个月以上而以往无代谢障碍的患者为调查对象,在6个病房中进行筛选,符合条件共170人,调查包括人口学资料(身高,体重,腰围,用药时间,糖尿病家族史)、最近一月的血脂水平(HDL,TG)、空腹血糖和血压等情况。结果精神分裂症患者中男性较女性更易罹患代谢综合征(P<0.01);精神分裂症患者中的吸烟者较不吸烟者更易罹患代谢综合征(P<0.05);而药物之间的比较并无显著性差异(P>0.05)。结论经典和非典型抗精神病药可能会引起代谢综合征或加重其发生的风险。  相似文献
9.
Associations between anxiety, depression, and the metabolic syndrome.   总被引:2,自引:0,他引:2  
BACKGROUND: There is limited evidence as to whether the metabolic syndrome (MetS) is associated with depression or anxiety and, if so, whether this association is gender-specific. This study investigated in each gender whether the MetS is associated with anxiety or depression and whether these relationships are independent of age, obesity, smoking status, socioeconomic factors, and lifestyle. METHODS: Metabolic syndrome (American Heart Association/National Heart, Lung, and Blood Institute criteria), depression, and anxiety (Hospital Anxiety and Depression Scale) were assessed in 1598 subjects at risk of cardiovascular disease. RESULTS: In both men and women, the MetS was associated with an increased prevalence of depression but not anxiety. The number of components of the MetS increased with increasing levels of depression but not anxiety. This association between the MetS and depressive symptoms was independent of age, smoking status, socioeconomic factors, and lifestyle. The relationship was observed across body mass index categories and was independent of anxiety. CONCLUSIONS: The MetS is associated with depression and depressive symptoms but not anxiety irrespective of gender and overweight/obesity status in subjects at risk of cardiovascular disease. These findings suggest a potential importance of screening for depression in patients with the MetS.  相似文献
10.
Snoring and the metabolic syndrome in women   总被引:2,自引:0,他引:2  
OBJECTIVE: The main objective was to examine the association between metabolic syndrome, snoring and sleep quality among women. METHODS: The study sample comprised healthy women (30-65 years) from the greater Stockholm area. Snoring and sleep quality were measured by the Karolinska Sleep Questionnaire. The metabolic syndrome was defined as the presence of two or more of the following components: (1) fasting serum glucose level > or =7.0 mmol/L; (2) arterial blood pressure > or =140/90 mmHg; (3) fasting serum triglycerides > or =1.7 mmol/L and/or HDL cholesterol <1.05 mmol/L; and (4) obesity (waist-to-hip ratio >0.85 and/or BMI > or =28 kg/m2). RESULTS: After adjustment for age, the risk ratio of metabolic syndrome among snorers as compared to non-snorers was 4.50 (95% CI: 1.71-11.86; p=0.002). This association persisted after controlling for menopausal status, educational level, smoking, fatigue and exercise habits. Poor sleep quality showed a trend (OR: 3.31; 95% CI: 0.89-12.21; p=0.073) towards an increased risk for metabolic syndrome, but this did not reach statistical significance. CONCLUSIONS: Snoring may be a strong predictor for metabolic syndrome in middle-aged women. These findings show that snoring women are not only at increased risk for individual risk factors associated with cardiovascular disease and type 2 diabetes, but also for metabolic syndrome.  相似文献
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