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1.
Axonal regrowth and restoration of visual function were studied in adult rats. The optic nerve was completely cut behind the eye. The proximal and distal nerve stumps were realigned and the meninges sutured back together. During the same surgical procedure, the lens was lesioned in order to induce secondary cellular cascades, which are known to strongly support the survival of retinal ganglion cells (RGCs) and to promote axonal regeneration. The anatomical and topographic restoration of the visual pathway was assessed neuroanatomically with the aid of anterograde and retrograde tracing using fluorescent dyes. It appeared that the axons formed growth cones at the junction of the suture soon after injury, before glial cells and extracellular matrix proteins were able to cause local scar formation. Growth cones first entered the distal optic nerve stump 3 days after injury, grew through it to reach the optic chiasm approximately 3 weeks after the lesion was made, and terminated within the retinoreceptive layers of the superior colliculus 5 weeks after lesioning. Quantification of the retrogradely labeled cell bodies within the regenerating retina revealed that up to 30% of the RGCs, which includes all major cell types, were capable of regenerating their axons along the entire visual pathway. To assess whether topography was restored, double-labeling experiments were performed, revealing only crude topographic restoration during the initial stages of regeneration. However, visual-evoked potentials could be recorded, indicating that synaptic transmission in higher visual areas was relatively intact. The data show, in principle, that cut axons can regenerate over long distances within the white matter of a central nerve like the adult optic nerve, spanning over 11 mm to the chiasm and between 12 and 15 mm to the thalamus and midbrain. The findings suggest, for the first time, that lentogenic stimulation of RGCs is sufficient to induce the formation of growth cones that can override inhibitors at the site of injury, grow through the white matter of the optic nerve, pass through the optic chiasm, and make synaptic connections within the brain.  相似文献
2.
精神分裂症首次发病患者治疗前后感觉门控功能的动态观察   总被引:23,自引:11,他引:12  
目的探讨精神分裂症首次发病(以下简称首发)患者治疗前后的听觉诱发电位P50变异的意义。方法应用美国Bravo脑电生理仪,采用条件刺激(S1)-测试刺激(S2)模式,分别于治疗前(66例)、治疗第5周(42例)和第12周(32例)对首发精神分裂症患者(患者组)进行P50检测,同时用阳性和阴性症状量表(PANSS)评定患者的临床症状;并以正常人(对照组,92名)的P50做比较。结果(1)治疗前,患者组的S1-P50波幅[(3±2)μV]低于对照组[(6±3)μV],S2-P50波幅[(4±2)μV]高于对照组[(2±1)μV],均P<0.01;患者组S2/S1比值[(81±40)%]高于对照组[(42±21)%],S1-S2波幅[(2±1)μV]低于对照组[(3±2)μV],100(1-S2/S1)值(19±17)低于对照组(58±21),差异均有统计学意义(P<0.05~0.01)。(2)患者组的S2/S1、S1-S2和100(1-S2/S1)与PANSS评分无相关性(P>0.05)。(3)与治疗前比较,患者组在治疗第5周末及第12周末P50的各项指标均无明显改变(均P>0.05)。结论P50变异可能是精神分裂症患者的早期改变,具有一定的属性标志特性,值得进一步随访研究。  相似文献
3.
五种脑诱发电位的相关性研究   总被引:20,自引:2,他引:18  
目的:研究提高5种脑诱发电位指标反映信息量的方法。方法:采用听觉脑干反应、听觉诱发电位、视觉诱发电位、事件相关电位P300、关联性负变5种脑诱发电位,对33名正常被试者进行检测,应用SPSS统计软件包进行主成分分析。结果:应用主成分分析的方法,从正常被试者的43个指标中提取出9个主成分,其反映的信息量为信息量的90.0%。结论:应用较少的主成分来反映多种脑诱发电位指标,可减少分析评价的变量数,并能较好地代表和评价多个脑诱发电位指标。  相似文献
4.
目的探讨精神分裂症首次发病(以下简称首发)患者和健康成年人听觉感觉门控电位P50的特点。方法采用听觉条件(S1)测-试刺激(S2)范式对58例首发精神分裂症患者(患者组)和108名健康成年人(正常对照组)进行P50检测,评定阳性和阴性症状量表(PANSS)。结果(1)在Cz、Fz和Pz脑区,正常对照组S1所诱发的P50波(S1-P50)潜伏期与S2所诱发的P50波(S2-P50)潜伏期的差异无统计学意义(P>0.05);S2-P50波幅[分别为(2.2±1.4)μV,(2.3±1.5)μV,(2.1±1.4)μV]低于S1-P50波幅[分别为(5.6±3.3)μV,(5.6±3.9)μV,(4.9±2.8)μV;P<0.01];S2/S1比值、S1-S2差值和100(1-S2/S1)的差异无统计学意义(P>0.05)。(2)与正常对照组比较,患者组在Cz、Fz和Pz脑区的S1-P50波幅低(Pz:Z=-2.030,P=0.042,余P<0.01),S2-P50波幅高;S2/S1比值高,S1-S2差值小,100(1-S2/S1)值低(P均<0.01)。(3)患者组的S2/S1比值、S1-S2差值和100(1-S2/S1)值与PANSS总分[(138.49±15.30)分]无相关性(P>0.05)。结论首发精神分裂症患者的感觉门控功能有异常,能通过感觉门控电位P50定量表达。  相似文献
5.
目的:通过诱发电位(EP)监测,探讨金尔伦(盐酸纳洛酮)治疗急性中,重型脑外伤的疗效,方法:对40例急性中,重型脑外伤患者者随机,双盲治疗,前3天剂量为每日0.3mg/kg,后7天剂量为4.8mg/日,于用药前,用药后30分钟,24小时,72小时,120小时监测正中神经短潜伏期体感诱发电位(SLSEP)和脑干听觉诱发电位(BAEP),揭盲后分为金尔伦治疗组和对照组,对金氽伦治疗组与对照组诱发电位进行统计学分析,结果:金尔伦治疗级SLSEP的N13-N20峰间潜伏期(N13-N20IPL)及BAEP的I-V波峰间潜伏期(I-VIPL)在用药手均较对组缩短且有显著性差异,P<0.05,结论,诱发电位监测结果表明,金尔伦能有效改善急性脑外伤患者异常的神经网络生理指标,对于急性中,重型脑外伤有明显的治疗作用。  相似文献
6.
The precise neural mechanisms underlying speech perception are still to a large extent unknown. The most accepted view is that speech perception depends on auditory-cognitive mechanisms specifically devoted to the analysis of speech sounds. An alternative view is that, crucial for speech perception, it is the activation of the articulatory (motor) gestures that generate these sounds. The listener understands the speaker when his/her articulatory gestures are activated (motor theory of speech perception). Here, by using transcranial magnetic stimulation (TMS), we demonstrate that, during speech listening, there is an increase of motor-evoked potentials recorded from the listeners' tongue muscles when the presented words strongly involve, when pronounced, tongue movements. Although these data do not prove the motor theory of speech perception, they demonstrate for the first time that word listening produces a phoneme specific activation of speech motor centres.  相似文献
7.
亚急性脊髓混合变性的17例临床特征和诊断   总被引:17,自引:0,他引:17  
目的评价亚急性脊髓混合变性(SCD)的临床特征及电生理和磁共振成像的诊断价值。方法回顾分析了17例SCD患者的临床表现。结果发现全部SCD患者发病由维生素B12缺乏引起,胃大部切除术是一个主要病因,肢体感觉异常和深感觉减退是SCD最常见的症状和体征,12例合并周围神经损害,5例合并植物神经损害,体感诱发电位有极高的敏感性,磁共振成像可以明确脱髓鞘的部位。结论电生理和磁共振检查对SCD的诊断和治疗起重要作用  相似文献
8.
Recent evidence indicates that direct current (DC) fields promote recovery of acutely injured central and peripheral nervous system axons. The polarity of the applied DC field may play an important role in modulating these effects. In the present study, the effect of DC field polarity on recovery of injured spinal cord axons was examined anatomically, electrophysiologically and behaviourly in a rat model. After a 53 g clip compression injury of the cord at T1, 30 adult rats were randomly and blindly allocated to one of three groups (n = 10 each): one group received implantation of a DC stimulator (14 microA) with the cathode caudal to the injury site; the second group received implantation of a similar stimulator with the cathode rostral to the injury site; and the third group received a sham (O microA) stimulator. Clinical neurological function was assessed by the inclined plane technique and axonal function was assessed by motor- and somatosensory-evoked potentials (MEP and SSEP). A quantitative assessment of axonal integrity was performed by counting neurons in the brain retrogradely labelled by the axonal tracer horseradish peroxidase (HRP) and by counting axons at the injury site. The inclined plane scores (P less than 0.0001), MEP amplitude (P less than 0.02), counts of neurons retrogradely labelled by HRP (P less than 0.0001), and axon counts at the injury site (P less than 0.01) were significantly greater in the group treated with a DC field with the cathode caudal to the lesion than in the other two groups. Conversely, the cathode rostral DC field caused a decrease in the number of neurons retrogradely labelled by HRP (P less than 0.05) compared to the sham and cathode caudal groups. These data confirm our previous finding that DC fields promote recovery of acutely injured spinal cord axons. Furthermore, the polarity of the applied field is of critical importance to this effect.  相似文献
9.
脑干及其附近手术诱发电位术中监护的研究   总被引:15,自引:1,他引:14  
目的 探讨脑干及其周围手术损伤与脑干听觉诱发电位(BAEP)和体感诱发电位(SEP)不同指标之间的关系,找出神经功能损伤第三的电生理指标。方法 对23例脑干肿瘤病人进行手术中BAEP和SEP连续监测。结果 脑干及其周围手术操作均可以引起BAEP、SEP的改变。SEP的N13-N20中枢传导时间(CCT)和N20潜伏期及波幅的变化和BAEPV波潜伏期(PL)、Ⅲ-V、I-V峰间潜伏期(IPL)的变化  相似文献
10.
听觉诱发电位监测在面肌痉挛显微血管减压术中的应用   总被引:14,自引:1,他引:13  
目的探讨减少显微血管减压术(MVD)治疗面肌痉挛术后听力障碍的有效方法。方法对440例面肌痉挛病人在MVD中采用脑干听觉诱发电位(BAEP)监测,根据监测结果的实时提示,找出影响听力的因素并加以解除。结果采用BAEP监测后术后听力障碍的发生率由以往手术的7.1%下降到目前的2.5%。结论术中BAEP监测对减少治疗面肌痉挛时所造成的听力障碍具有显著的意义。  相似文献
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