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目的 观察奥氮平对雄性小鼠能量消耗和糖代谢的影响及可能机制.方法 将10只C57BL/6J雄性小鼠随机分为两组,分别奥氮平及其溶剂灌胃2周,观察小鼠摄食、体质量、空腹血糖、糖耐量和胰岛素耐量的变化,监测24 h能量代谢,并比较肝脏糖代谢相关基因的表达.结果 小鼠奥氮平给药后出现胰岛素抵抗和高血糖;白天能量消耗明显下降,呼吸商趋势性下降,氧化底物由葡萄糖向脂肪转移;肝内糖异生关键酶磷酸烯醇式丙酮酸羟激酶(PEPCK)和葡萄糖-6-磷酸酶(G-6-pase)的基因表达明显升高.结论 奥氮平诱导的高血糖可不依赖于摄食和体质量增加;奥氮平可直接诱导胰岛素抵抗并促进肝糖异生.  相似文献
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We have investigated the effects of stimulation frequency and pulse duration on fatigue and energy metabolism in rat gastrocnemius muscle during a single bout of neuromuscular electrical stimulation (NMES). Electrical pulses were delivered at 100 Hz (1‐ms pulse duration) and 20 Hz (5‐ms pulse duration) for the high (HF) and low (LF) frequency protocols, respectively. As a standardization procedure, the averaged stimulation intensity, the averaged total charge, the initial peak torque, the duty cycle, the contraction duration and the torque‐time integral were similar in both protocols. Fatigue was assessed using two testing trains delivered at a frequency of 100 Hz and 20 Hz before and after each protocol. Metabolic changes were investigated in vivo using 31P‐magnetic resonance spectroscopy (31P‐MRS) and in vitro in freeze‐clamped muscles. Both LF and HF NMES protocols induced the same decrease in testing trains and metabolic changes. We conclude that, under carefully controlled and comparable conditions, the use of low stimulation frequency and long pulse duration do not minimize the occurrence of muscle fatigue or affect the corresponding stimulation‐induced metabolic changes so that this combination of stimulation parameters would not be adequate in the context of rehabilitation. Muscle Nerve, 2010  相似文献
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