首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1769篇
  国内免费   28篇
  完全免费   48篇
  神经病学   1845篇
  2015年   13篇
  2014年   75篇
  2013年   74篇
  2012年   93篇
  2011年   160篇
  2010年   105篇
  2009年   132篇
  2008年   106篇
  2007年   80篇
  2006年   129篇
  2005年   88篇
  2004年   76篇
  2003年   76篇
  2002年   59篇
  2001年   54篇
  2000年   45篇
  1999年   43篇
  1998年   28篇
  1997年   29篇
  1996年   22篇
  1995年   27篇
  1994年   18篇
  1993年   19篇
  1992年   14篇
  1991年   22篇
  1990年   17篇
  1989年   15篇
  1988年   9篇
  1987年   14篇
  1986年   20篇
  1985年   22篇
  1984年   30篇
  1983年   28篇
  1982年   28篇
  1981年   13篇
  1980年   15篇
  1979年   16篇
  1978年   5篇
  1977年   4篇
  1976年   8篇
  1975年   1篇
  1974年   1篇
  1973年   4篇
  1972年   7篇
  1968年   1篇
排序方式: 共有1845条查询结果,搜索用时 359 毫秒
1.
Quality of Life of People with Epilepsy: A European Study   总被引:36,自引:18,他引:18  
Summary: Purpose: To study the impact of epilepsy and its treatment on people with epilepsy in Europe. We therefore aimed to collect data from as many countries as possible.
Methods: Clinical and demographic details and information about psychosocial functioning was collected using self-completed questionnaires mailed to members of epilepsy support groups.
Results: Quality of life data was collected from >5,000 patients living in 15 countries in Europe. Over a third of all respondents had frequent seizures, and a fifth believed that their seizures were not well enough controlled by antiepileptic medication. Reported levels of side effects from medication were high. A significant number of respondents reported changing their medication because of side effects or poor control. Respondents reported that epilepsy and its treatment had a significant impact on a number of different aspects of their daily lives. Half of all respondents felt stigmatised by their epilepsy. There were significant differences by seizure type and frequency in the way respondents scored on measures of the perceived impact of their condition, the stigma associated with it and their health status as measured by a generic scale, the SF36.
Conclusions: This study confirms the findings of previous smaller-scale studies that reducing side effects and achieving better control of seizures are key to improving the quality of life of people with epilepsy, as is reducing the stigma and handicap associated with it.  相似文献
2.
利培酮对心电图的影响   总被引:28,自引:0,他引:28  
目的研究利培酮引起心电图改变的特征及其与服药时间、剂量之间的关系,并与氯氮平引起的心电图改变作比较.方法对符合CCMD-2-R诊断标准的精神分裂症、分裂样精神障碍患者,在服药前、服药后4周、8周分别作心电图检查,记录服药剂量与心电图改变的情况,并在利培酮组与氯氮平组之间作显著性检验.结果利培酮引起的心电图改变主要为窦性心动过速、T波变化,其程度及发生率均低于氯氮平,一般不影响治疗.并且与服药天数、剂量大小有一定的关系.结论利培酮可引起心电图的改变,其程度及发生率低于氯氮平.  相似文献
3.
微创血肿清除术治疗高血压脑出血疗效分析   总被引:27,自引:5,他引:22  
目的比较微创血肿粉碎清除术与开颅血肿清除术的疗效。方法对两组高血压脑出血患者分别行微创血肿粉碎清除术和开颅血肿清除术,对两组疗效、死亡率进行卡方检验,并对两组疗效进行多元线性回归分析。结果微创组有效率66.67%(40/60),死亡率16.67%(10/60);手术组有效率57.89%(33/57),死亡率29.82%(17/57),两组间有效率和死亡率均无显著差异(P〉0.05)。微创组疗效回归方程为y=0.732—0.418X1-0.119X2,X1为有无并发症,X2为人院状态;手术组疗效回归方程为Y=-0.665+0.024X1-0.216X2+0.016X3-0.291X4,X1为GCS评分、X2为有无并发症,X3为患者年龄,X4为有无脑疝。两组方程中Y均代表神经功能缺损评分减少百分数。结论微创血肿粉碎清除术是治疗高血压脑出血的有效方法。  相似文献
4.
利培酮对老年期精神障碍的临床应用   总被引:24,自引:4,他引:20  
目的 :了解利培酮治疗老年期精神障碍患者的用药特点、疗效及锥体外系反应 (EPS)。 方法 :调查 5 8例以利培酮治疗 4周以上、年龄≥ 6 0岁的住院老年病人。 结果 :老年病人的平均起始剂量为 (1.2 8± 0 .6 3) m g/ d,平均治疗剂量 (2 .90± 1.2 4) m g/ d,总有效率 86 .2 % ,锥体外系反应发生率31.0 %。脑器质性精神障碍的起始和治疗剂量均低于精神分裂症 ,而疗效优于精神分裂症。晚发精神分裂症的疗效优于早发精神分裂症 ,二者的治疗剂量差异不明显。EPS的发生与剂量有关。 结论 :利培酮治疗老年期精神障碍疗效好、剂量低。  相似文献
5.
Sodium Valproate: Monotherapy and Polytherapy   总被引:22,自引:19,他引:3  
Summary: Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has been achieved in more than 80% of patients with absence, myoclonic, and primary tonic-clonic seizures, in 72% of those with photosenstivie epilepsy including eyelid myoclonia, and in 47% of partial epilepsies, for which carbamazepine was the initial drug of choice. Only 21% of those with myoclonic astatic epilepsy have become free from seizures. At first VPA was given twice daily, but in recent years it was given once daily, as this was more effective. Reasons for failure of VPA therapy are given. Side effects in 436 patients (100 more patients were added for this assessment only) were uncommon, though where they did occur, weight increase was the most frequent. Platelets were reduced without clinical problems. There were no severe hepatic disorders. Serum levels were assessed in seizure-free patients, and the optimum level was between 60 and 120 mg/L (most patients received between 20 and 30 mg/kg). VPA was given during 30 pregnancies, and there was no evidence of teratogenicity on monotherapy. VPA is most effective in primary generalized epilepsy, especially if given as the sole antiepileptic drug. If the daily dose does not exceed 40 mg/kg or 2.5 g, it is singularly free from serious side effects.  相似文献
6.
亚低温在治疗急性颅脑创伤中的疗效和争议   总被引:22,自引:1,他引:21  
二十世纪90年代初,国内外对亚低温脑保护的作用有了新认识。动物实验研究发现亚低温对实验性颅脑外伤具有显著的治疗保护作用。大多数前瞻性临床应用研究发现30~33℃亚低温能显著降低重型颅脑伤患者的死残率。但美国Clifton教授牵头的9个医学中心合作研究发现亚低温治疗组与对照组无统计学差异.仅能显著提高GCS 6~8分、年龄<45岁、伤后6h内达到亚低温水平的病人的治疗效果。最近一项欧州5家医院多中心前瞻性随机临床研究结果令人兴奋,他们研究证明亚低温对心跳骤停脑缺血缺氧病人有显著治疗保护作用。目前国内外有关亚低温治疗的争议焦点是亚低温治疗的指征、时间窗和时程。  相似文献
7.
Effectiveness of First Antiepileptic Drug   总被引:21,自引:14,他引:7  
PURPOSE: To investigate the interaction among efficacy, tolerability, and overall effectiveness of the first antiepileptic drug (AED) in patients with newly diagnosed epilepsy. METHODS: The 470 patients were diagnosed, treated and followed up from January 1984 at a single center. Outcome was classified as seizure freedom for at least the last year or failure of initial treatment because of inadequate seizure control, adverse events, or for other reasons. RESULTS: Overall, 47% of patients became seizure-free with the first prescribed AED. A higher proportion (p = 0.025) of patients with symptomatic or cryptogenic epilepsy changed treatment because of intolerable side effects (17%), and a lower proportion (p = 0.007) became seizure-free (43.5%) compared with those with idiopathic epilepsy (8.5% and 58%, respectively). Most patients (83%) received carbamazepine (CBZ; n = 212), sodium valproate (VPA; n = 101), or lamotrigine (LTG; n = 78). The majority of seizure-free patients required only a moderate daily AED dose (93.1% with < or =800 mg CBZ, 91.3% with < or =1,500 mg VPA, 93.8% with < or =300 mg LTG), with commonest dose ranges being 400-600 mg for CBZ, 600-1,000 mg for VPA, and 125-200 mg for LTG. Most withdrawals due to poor tolerability also occurred at or below these dose levels (CBZ: 98%; VPA: 100%; LTG: 75%). Patients taking CBZ (27%) had a higher incidence of adverse events necessitating a change of treatment than did those treated with VPA (13%) or LTG (10%), resulting in fewer becoming seizure-free (CBZ vs. VPA, p = 0.02; CBZ vs. LTG, p = 0.002). CONCLUSIONS: Nearly 50% of newly diagnosed patients became seizure-free on the first-ever AED, with >90% doing so at moderate or even modest dosing. Tolerability was as important as efficacy in determining overall effectiveness.  相似文献
8.
脑功能磁共振成像研究进展   总被引:21,自引:0,他引:21  
主要综述fMRI产生的历史、成像原理、成像技术和方法、已经取得的成绩以及将来研究发展的方向等。fMRI产生技术广泛应用的20世纪90年代,主要受快速成像技术的影响,从有创走向无创,从而受到神经、认知和心理科学领域的极大关注。fMRI原理是根据神经元兴奋后局部氧耗与血流增幅不一致,而BOLD效应机制成像,间接显示神经元活动。成像主要采用平面回波成像(EPI)和快速小角度激发(FLASH)技术、二者在时间和空间分辨率上各有优劣。最后几年来,fMRI技术对脑功能的研究已取得了巨大的成绩,估计将在这一领域继续拥有非常重要的地位。将来fMRI可能主要在BOLD效应的生理过程、临床应用以及高场磁体的应用等领域进一步展开。  相似文献
9.
PURPOSE: To assess which antiepileptic medications (AEDs) have the best evidence for long-term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or untreated epilepsy. METHODS: A 10-member subcommission of the Commission on Therapeutic Strategies of The International League Against Epilepsy (ILAE), including adult and pediatric epileptologists, clinical pharmacologists, clinical trialists, and a statistician evaluated available evidence found through a structured literature review including MEDLINE, Current Contents and the Cochrane Library for all applicable articles from 1940 until July 2005. Articles dealing with different seizure types (for different age groups) and two epilepsy syndromes were assessed for quality of evidence (four classes) based on predefined criteria. Criteria for class I classification were a double-blind randomized controlled trial (RCT) design, >or=48-week treatment duration without forced exit criteria, information on >or=24-week seizure freedom data (efficacy) or >or=48-week retention data (effectiveness), demonstration of superiority or 80% power to detect a 相似文献
10.
大鼠海马干细胞移植治疗颞叶癫痫的初步研究   总被引:19,自引:1,他引:18  
目的 通过神经干细胞移植至癫痫鼠后与宿主细胞的整合及其对损伤宿主的修复作用,为神经干细胞移植治疗癫痫提供理论依据。方法 分离、培养新生鼠海马干细胞,移植至海人酸(KA)所致癫痫模型鼠的右侧海马内,应用Timm、Nissl、HE染色及动态脑电记录仪记录脑电图。在光镜及电镜下比较正常对照组、移植组及KA未移植组大鼠,在移植后的1周、4周、8周及24周苔状纤维发芽(MSF)、海马CA3区锥体神经元损伤情况及海马、杏仁核的脑电变化。结果 海马干细胞的移植可以显著抑制KA引起的MFS,其抑制作用从移植后第4周开始,第8周时最强,持续至第24周;同时亦明显的减轻了KA所致的CA3区锥体细胞缺失,其作用在第8周最强;KA所致CA3区锥体神经元超微结构的损伤亦得到一定程度的修复;但是,干细胞的移植并未使宿主恢复到损伤前的水平,海马干细胞移植可减少癫痫动物脑电的痫性发放,并降低其癫痫波的波幅约50%。结论 神经干细胞移植对于KA诱发癫痫鼠具有显著的修复作用,其具体作用机制还有待于进一步的研究。  相似文献
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号