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1.
电针对慢性应激抑郁模型大鼠脑单胺类神经递质的影响   总被引:72,自引:3,他引:69  
目的 探讨电针刺激百会、印堂穴对慢性应激抑郁模型大鼠脑内单胺类神经递质的影响及治疗抑郁症的机理。方法 将24 只SpragueDawley 雄性大鼠随机分为对照组、抑郁模型组、抑郁模型加电针组和抑郁模型加阿米替林组,每组6 只。用高效液相电化学法测定大鼠脑内单胺类神经递质及其代谢产物的含量,比较含量的比值。结果 抑郁模型组大鼠脑皮层5羟色胺(5HT)/5羟吲哚乙酸(5HIAA) 、纹状体多巴胺(DA)/3,4二羟基苯乙酸(DOPAC) 分别为0-50 ±0-17,10-37 ±1-40,低于对照组( 分别为0-88±0-25 ,12-36 ±1-50),P< 0-05 ;皮层去甲肾上腺素(NE)/5HT(2-88 ±1-00) 高于对照组(1-73±0-40) ,P< 0-05。电针刺激百会、印堂穴可使模型大鼠脑皮层5HT/5HIAA 与NE/5HT恢复正常(P<0-05) ,对纹状体DA/DOPAC 的降低无影响( P> 0-05)。结论 提示电针刺激百会、印堂穴通过降低皮层5HT的代谢,提高5HT能神经的活性,并协调NE 与5HT之间的平衡来发挥抗抑郁作用。  相似文献
2.
卒中后抑郁状态患者的血浆、脑脊液单胺类神经递质测定   总被引:44,自引:0,他引:44  
目的 探讨卒中后抑郁状态与血浆、脑脊液单胺类递质水平的关系。方法 采用高压液相色谱仪 ,测定 32例卒中后抑郁状态患者、30例卒中后无抑郁状态患者及 2 8名正常人的血浆、脑脊液单胺类递质水平 ,进行对照分析。结果 卒中后抑郁状态患者血浆、脑脊液中单胺类递质水平[多巴胺 (DA) =(2 6± 0 4) μmol L ,(2 0± 0 3) μmol L ;去甲肾上腺素 (NE) =(0 19± 0 0 6 ) μmol L ,(0 14± 0 0 6 ) μmol L ;5 羟色胺 (5 HT) =(1 0 9± 0 30 ) μmol L ,(0 6 0± 0 12 ) μmol L]低于卒中后无抑郁组 [DA =(3 2± 0 5 ) μmol L ,(2 6± 0 4) μmol L ;NE =(0 31± 0 12 ) μmol L ,(0 2 8± 0 0 8) μmol L ;5 HT=(1 31± 0 40 ) μmol L ,(1 11± 0 40 ) μmol L]及正常对照组 [DA =(2 9± 0 5 ) μmol L ,(2 2± 0 6 )μmol L ;NE =(0 2 7± 0 70 ) μmol L ,(0 2 3± 0 0 8) μmol L ;5 HT =(1 19± 0 30 ) μmol L ,(0 88± 0 0 7)μmol L],而大脑左侧及前部卒中患者的血浆、脑脊液中单胺类递质水平低于其它卒中部位患者 (P <0 0 5 ) ,脑脊液单胺类递质水平与抑郁程度呈负相关 (P <0 0 5 )。结论 卒中后抑郁状态的发生与血浆、脑脊液中单胺类神经递质的降低有关  相似文献
3.
大鼠抑郁模型的脑磁共振成像研究   总被引:31,自引:0,他引:31  
目的研究大鼠抑郁模型脑磁共振成像(MRI)的变化。方法选择OPENFIELD法评分相近的50只成年SD雄性大鼠随机分为对照组和抑郁组,每组各25只。应用分养和长期不可预见性中等强度应激所造成的大鼠抑郁模型。以敞箱实验等方法测定动物行为;MRIT2加权象对照研究抑郁大鼠脑内整体形态学及各脑区信号强度的改变。结果与对照组比较,抑郁组大鼠大脑纵裂深度加深[抑郁组(2.05±0.16)mm,对照组(1.83±0.21)mm,P<0.05]、体积扩大[抑郁组(343.00±78.87)mm3,对照组(258.00±13.59)mm3,P<0.05]。抑郁大鼠边缘系统各脑区T2加权象信号强度增加。结论提示抑郁大鼠存在脑萎缩,边缘系统各脑区水的流动性增加。  相似文献
4.
The genetics of depression: a review.   总被引:23,自引:0,他引:23  
Major depressive disorder (MDD) is common and moderately heritable. Recurrence and early age at onset characterize cases with the greatest familial risk. Major depressive disorder and the neuroticism personality trait have overlapping genetic susceptibilities. Most genetic studies of MDD have considered a small set of functional polymorphisms relevant to monoaminergic neurotransmission. Meta-analyses suggest small positive associations between the polymorphism in the serotonin transporter promoter region (5-HTTLPR) and bipolar disorder, suicidal behavior, and depression-related personality traits but not yet to MDD itself. This polymorphism might also influence traits related to stress vulnerability. Newer hypotheses of depression neurobiology suggest closer study of genes related to neurotoxic and neuroprotective (neurotrophic) processes and to overactivation of the hypothalamic-pituitary axis, with mixed evidence regarding association of MDD with polymorphisms in one such gene (brain-derived neurotrophic factor [BDNF]). Several genome-wide linkage studies of MDD and related traits have been reported or are near completion. There is some evidence for convergence of linkage findings across studies, but more data are needed to permit meta-analysis. Future directions will include more intensive, systematic study of linkage candidate regions and of the whole genome for genetic association; gene expression array studies; and larger-scale studies of gene-environment interactions and of depression-related endophenotypes.  相似文献
5.
Low glial numbers in the amygdala in major depressive disorder.   总被引:18,自引:0,他引:18  
BACKGROUND: Functional imaging studies implicate the prefrontal cortex and amygdala in major depressive disorder and bipolar disorder, and glial decreases have been reported in the prefrontal cortex. Here, glia and neurons were counted in the amygdala and entorhinal cortex in major depressive disorder, bipolar disorder, and control cases. METHODS: Tissue blocks from major depressive disorder (7), bipolar disorder (10), and control (12) cases, equally divided between right and left, were cut into 50 microm sections and stained with the Nissl method. One major depressive disorder and all but two bipolar disorder cases had been treated with lithium or valproate. Neurons and glia were counted using stereological methods. RESULTS: Glial density and the glia/neuron ratio were substantially reduced in the amygdala in major depressive disorder cases. The reduction was mainly accounted for by counts in the left hemisphere. No change was found in neurons. Average glia measures were not reduced in bipolar disorder cases; however, bipolar disorder cases not treated with lithium or valproate had significant glial reduction. Similar but smaller changes were found in the entorhinal cortex. CONCLUSIONS: Glia are reduced in the amygdala in major depressive disorder, especially on the left side. The results suggest that lithium and valproate may moderate the glial reduction.  相似文献
6.
北京市抑郁症的患病率调查   总被引:18,自引:0,他引:18  
目的掌握北京市常住人口中抑郁症的患病率及其特征。方法以复合性国际诊断交谈检查核心本1.0版为主要调查工具,按多阶段分层系统随机抽样原则,对北京市18个区县≥15岁人口5926人进行抑郁症的现况调查。结果(1)时点患病率为3.31%(196例),终生患病率为6.87%(407例)。(2)时点和终生患病率中,均为女性(分别为4.40%和8.46%)高于男性(2.45%和5.01%),年龄≥55岁者高,农村(4.19%和7.98%)高于城市(2.50%和6.07%),文盲(6.02%和10.87%)和小学文化程度者(5.42%和10.64%)高,再婚(9.52%和28.57%)、离婚(6.15%和13.85%)和丧偶者(5.43%和11.27%)高,不在业者(3.96%和7.95%)、月收入≤300元者(5.52%和9.13%)及有家庭暴力者(6.51%和15.38%)高,均P〈0.01~0.05。结论抑郁症是一种患病率较高的常见精神障碍,预防控制抑郁症应成为我国医疗卫生工作的重点之一。  相似文献
7.
BACKGROUND: Depression has a significant impact on poststroke recovery and mortality. There are a proportion of patients with poststroke depression (PSD) who do not respond to antidepressants. Repetitive Transcranial Magnetic Stimulation (rTMS) might be a safe and effective alternative in these refractory cases. METHODS: We conducted a randomized, parallel, double-blind study of active versus sham left prefrontal rTMS in patients with refractory PSD. After discontinuing antidepressants, patients were randomly assigned to receive 10 sessions of active (10 Hz, 110% of the motor threshold, 20 trains of 5 seconds duration) or sham left prefrontal rTMS. Efficacy measures included HAM-D scores, response and remission rates. Patients completed a neuropsychological battery at baseline and after completing the protocol. RESULTS: When compared with sham stimulation, 10 sessions of active rTMS of the left dorsolateral prefrontal cortex were associated with a significant reduction of depressive symptoms. This reduction was not influenced by patient's age, type or location of stroke, volume of left frontal leukoaraiosis or by the distance of the stimulating coil to the prefrontal cortex. However, there was a significant positive correlation between the percentage of reduction of Ham-D scores and frontal gray and white matter volumes. There were no significant changes in cognitive functioning between the active and the sham stimulation groups. In addition, there were few and mild adverse effects that were equally distributed among groups. CONCLUSIONS: Taken together, these preliminary findings suggest that rTMS may be an effective and safe treatment alternative for patients with refractory depression and stroke.  相似文献
8.
There are major concerns that specific agonal conditions, including coma and hypoxia, might affect ribonucleic acid (RNA) integrity in postmortem brain studies. We report that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays. In contrast to agonal factors, gender, age, and postmortem factors have less effect on gene expression profiles. The Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles. Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects.  相似文献
9.
抑郁症及其亚型的睡眠脑电图研究   总被引:12,自引:1,他引:11  
目的 探讨抑郁症患者睡眠脑电图的异常改变以及抑郁闰不同亚型之间的差异。方法 采用日本光电RM-6000多导生理记录仪,对18例抑郁症患者和19名健康人进行睡眠脑电图检查。结果 与对照组比较,抑郁症组出现明显的醒觉时间增多、睡眠总时间减少、晒起时间增加、睡眠效率下降、睡眠维持率下降、第一阶段睡眠百分比增加、快速眼球运动(REM)潜代期缩短和REM密度增加,经统计学处理差异均有显著性(P〈0.05)。  相似文献
10.
艾司西酞普兰与舍曲林治疗门诊抑郁症的对照研究   总被引:12,自引:0,他引:12  
目的 探讨艾司西酞普兰对门诊抑郁症病人的疗效和安全性。方法 68例符合CCMD-3抑郁发作的门诊病人随机分为艾司西酞普兰组和舍曲林组,艾司西酞普兰剂量10—20mg/d,舍曲林50~200mg/d,疗效采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定,不良反应和安全性用TESS和实验室检查评定。观察时间为期6周。结果 艾司西酞普兰组有效率70.6%,治愈率47.1%,舍曲林组有效率61.8%,治愈率41.2%,两组比较差异无显著性。艾司西酞普兰主要不良反应为食欲下降(11.8%)、恶心(8.8%)、头晕(8.8%)、口干(5.9%)等,与舍曲林无差异。脱落率和失访率各为11.8%和14.7%,无显著差异。结论 艾司西酞普兰治疗门诊抑郁症病人安全有效,疗效和不良反应与舍曲林相似。  相似文献
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