首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8245篇
  国内免费   57篇
  完全免费   861篇
  神经病学   9163篇
  2020年   3篇
  2019年   122篇
  2018年   383篇
  2017年   404篇
  2016年   410篇
  2015年   256篇
  2014年   609篇
  2013年   553篇
  2012年   527篇
  2011年   813篇
  2010年   569篇
  2009年   731篇
  2008年   774篇
  2007年   594篇
  2006年   335篇
  2005年   276篇
  2004年   274篇
  2003年   267篇
  2002年   239篇
  2001年   108篇
  2000年   2篇
  1999年   87篇
  1998年   68篇
  1997年   78篇
  1996年   50篇
  1995年   50篇
  1994年   38篇
  1993年   39篇
  1992年   38篇
  1991年   36篇
  1990年   25篇
  1989年   32篇
  1988年   24篇
  1987年   25篇
  1986年   23篇
  1985年   76篇
  1984年   50篇
  1983年   44篇
  1982年   34篇
  1981年   28篇
  1980年   12篇
  1979年   16篇
  1978年   8篇
  1977年   11篇
  1976年   6篇
  1975年   1篇
  1974年   5篇
  1973年   2篇
  1972年   4篇
  1971年   2篇
  1970年   2篇
排序方式: 共有9163条查询结果,搜索用时 31 毫秒
1.
BACKGROUND: Positron emission tomography (PET) studies of major depression have revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI has been adapted to examine connectivity within a specific resting-state neural network--the default-mode network--that includes medial prefrontal and anterior cingulate cortices. The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls. METHODS: Twenty-eight subjects with major depression and 20 healthy controls underwent 5-min fMRI scans while resting quietly. Independent component analysis was used to isolate the default-mode network in each subject. Group maps of the default-mode network were compared. A within-group analysis was performed in the depressed group to explore effects of depression refractoriness on functional connectivity. RESULTS: Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. Within the depressed group, the length of the current depressive episode correlated positively with functional connectivity in the subgenual cingulate. CONCLUSIONS: This is the first study to explore default-mode functional connectivity in major depression. The findings provide cross-modality confirmation of PET studies demonstrating increased thalamic and subgenual cingulate activity in major depression. Further, the within-subject connectivity analysis employed here brings these previously isolated regions of hypermetabolism into the context of a disordered neural network. The correlation between refractoriness and subgenual cingulate functional connectivity within the network suggests that a quantitative, resting-state fMRI measure could be used to guide therapy in individual subjects.  相似文献
2.
北京市抑郁症的患病率调查   总被引:18,自引:0,他引:18  
目的掌握北京市常住人口中抑郁症的患病率及其特征。方法以复合性国际诊断交谈检查核心本1.0版为主要调查工具,按多阶段分层系统随机抽样原则,对北京市18个区县≥15岁人口5926人进行抑郁症的现况调查。结果(1)时点患病率为3.31%(196例),终生患病率为6.87%(407例)。(2)时点和终生患病率中,均为女性(分别为4.40%和8.46%)高于男性(2.45%和5.01%),年龄≥55岁者高,农村(4.19%和7.98%)高于城市(2.50%和6.07%),文盲(6.02%和10.87%)和小学文化程度者(5.42%和10.64%)高,再婚(9.52%和28.57%)、离婚(6.15%和13.85%)和丧偶者(5.43%和11.27%)高,不在业者(3.96%和7.95%)、月收入≤300元者(5.52%和9.13%)及有家庭暴力者(6.51%和15.38%)高,均P〈0.01~0.05。结论抑郁症是一种患病率较高的常见精神障碍,预防控制抑郁症应成为我国医疗卫生工作的重点之一。  相似文献
3.
Phenomenology of Depression in Epilepsy   总被引:17,自引:17,他引:6  
Sixty-six patients with epilepsy and depression were studied. Thirty-four had a family history of psychiatric illness; depression was the most common condition. Assessed using standardised rating scales, the severity of the depression was moderate and was endogenous in approximately 40% of patients. Attendant features were high state and trait anxiety and hostility. The EEGs of the patients and a control group were not significantly different. Patients receiving phenobarbital (PB) were more depressed, whereas those taking carbamazepine (CBZ) were both less depressed and less anxious. The phenomenology of the depression was not clearly influenced by epilepsy variables. We suggest that the depression in patients with epilepsy represents the outcome of multiple factors in genetically predisposed individuals.  相似文献
4.
度洛西汀与文拉法辛对首发抑郁症疗效的对照研究   总被引:13,自引:1,他引:12  
目的观察固定剂量度洛西汀与文拉法辛对首发抑郁症患者的疗效和安全性。方法73例首发抑郁症患者随机分为度洛西汀组(36例)和文拉法辛组(37例),治疗剂量分别为60mg/d和150mg/d,观察8周。用汉密尔顿抑郁量表(HAMD17)和蒙哥马利抑郁量表(MADRS)评定疗效,不良反应量表(TESS)评定不良反应和安全性。结果度洛西汀组31例和文拉法辛组30例完成8周的观察。至第8周末两组的有效率和临床痊愈率分别为77.4%(24/31)、83.3%(25/30)和48.4%(15/31)、53.3%(16/30),差异无统计学意义。治疗第1周末,文拉法辛组起效率(80.0%)高于度洛西汀组(41.9%)。度洛西汀组主要不良反应为食欲减退、恶心、心动过速、头痛、震颤、口干和便秘,与文拉法辛组相似。结论度洛西汀对首发抑郁症患者安全有效,与文拉法辛相似。  相似文献
5.
帕金森病患者的抑郁与认知功能障碍   总被引:12,自引:4,他引:8  
目的探讨帕金森病(PD)患者的抑郁与认知功能障碍之间的关系。方法对60名PD患者和38名对照组进行抑郁和认知功能评定。结果PD组HAMD均分(16.8±0.6),对照组(7.2±2.8);PD组的认知功能与对照组相比下降;PD并抑郁患者的认知功能与PD并非抑郁患者的认知功能相比有显著性差异(P<0.05)。结论PD患者存在抑郁与认知功能障碍,抑郁可能是导致认知功能下降的重要因素。  相似文献
6.
艾司西酞普兰与舍曲林治疗门诊抑郁症的对照研究   总被引:12,自引:0,他引:12  
目的 探讨艾司西酞普兰对门诊抑郁症病人的疗效和安全性。方法 68例符合CCMD-3抑郁发作的门诊病人随机分为艾司西酞普兰组和舍曲林组,艾司西酞普兰剂量10—20mg/d,舍曲林50~200mg/d,疗效采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定,不良反应和安全性用TESS和实验室检查评定。观察时间为期6周。结果 艾司西酞普兰组有效率70.6%,治愈率47.1%,舍曲林组有效率61.8%,治愈率41.2%,两组比较差异无显著性。艾司西酞普兰主要不良反应为食欲下降(11.8%)、恶心(8.8%)、头晕(8.8%)、口干(5.9%)等,与舍曲林无差异。脱落率和失访率各为11.8%和14.7%,无显著差异。结论 艾司西酞普兰治疗门诊抑郁症病人安全有效,疗效和不良反应与舍曲林相似。  相似文献
7.
Depression, Locus of Control, and the Effects of Epilepsy Surgery   总被引:10,自引:10,他引:3  
The purposes of this investigation were (a) to determine the relationship between interictal depression and a potential psychosocial risk factor (locus of control), (b) to examine changes in self-reported depression after anterior temporal lobectomy (ATL), and (c) relate postoperative changes in depression to alterations in surgical outcome and locus of control. Thirty-seven patients with intractable seizures of temporal lobe origin were administered measures of depression and locus of control both preoperatively and 6 months postoperatively. Results revealed a significant preoperative relationship between depression and an external locus of control, but this relationship no longer existed postoperatively. Postoperative declines in depression were independent of any alterations in locus of control. Further analyses revealed that depression declined significantly only in patients rendered completely seizure-free by ATL, whereas patients who were significantly improved (greater than or equal to 75% reduction in seizure frequency) but continued to experience some seizure activity showed no changes in self-reported depression. Finally, a wide variety of neurologic and seizure-related variables were shown to be unrelated to depression. The clinical and theoretical significance of these findings is discussed.  相似文献
8.
Symptoms of Depression and Anxiety in Pediatric Epilepsy Patients   总被引:10,自引:10,他引:0  
Summary: Purpose: We assessed rates of symptoms of anxiety and depression among pediatric patients with epilepsy.
Methods: We administered the Revised Child Manifest Anxiety Scale (RCMAS), and Child Depression Inventory (CDI) to 44 epilepsy patients aged 7–18 years (mean age 12.4 years). Demographic, socioeconomic, and epilepsy-related information was examined in relation to depression and anxiety scores.
Results: No patients had been previously identified to have depression or anxiety. However, 26% had significantly increased depression scores and 16% met critieria for significant anxiety symptomatology.
Conclusions: Symptoms of depression and anxiety are common among pediatric patients with epilepsy and appear to be overlooked by care providers.  相似文献
9.
上海市中学生抑郁症状现状及其与生活事件关系的研究   总被引:9,自引:1,他引:8  
目的 了解上海市初中和高中学生抑郁症状的现状及其与生活事件的关系.方法 采取横断面调查,使用流调用抑郁自评量表和简易生活事件量表对1 818名中学生进行了抑郁症状调查及其与生活事件的关系.结果 中学生有肯定抑郁症状的检出率为18.6%,其中男生为22.66%,女生为14.78%,男生高于女生( χ2=24.52,P<0.01);初一年级学生抑郁症状的检出率为15.89%、初二15.48%、初三17.26%、高一14.33%、高二24.70%、高三25.67%,高二和高三抑郁症状发生率显著高于初中和高一学生(χ2=33.40,P<0.01).负性生活事件的总分与抑郁症状的总分呈正相关;出现频率最高的生活事件是明显的学习压力或考试失败,对学生影响程度也最高,其次是受到批评.结论 中学生中抑郁症状是常见的,负性生活事件与抑郁症状有相关性.  相似文献
10.
OBJECTIVE: The purpose of this study was to examine whether there is a bidirectional relationship between, on one hand, anxiety and depression and, on the other hand, insomnia over the course of a year. METHODS: A randomly selected sample of 3000 participants from the general population filled out a baseline survey (N=1812) and a 1-year follow-up survey (N=1498) on anxiety, depression, and insomnia. RESULTS: On cross-sectional analyses, bivariate correlations showed that anxiety, depression, and insomnia were significantly intercorrelated (varphi=.31-.54). On prospective analyses, logistic regression analyses demonstrated that anxiety at baseline [odds ratio (OR)=4.27 (8% of variance)] and depression at baseline [OR=2.28 (2% of variance)] were related to new cases of insomnia on follow-up. Furthermore, insomnia at baseline was related to new episodes of high anxiety and high depression on follow-up [OR=2.30 (2% of variance) and OR=3.51 (4% of variance), respectively]. CONCLUSION: Evidence suggests that there is a bidirectional relationship between, on one hand, anxiety and depression and, on the other hand, insomnia. This suggests that anxiety, depression, and insomnia are intertwined over time, implying implications for theoretical conceptualizations and interventions.  相似文献
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号