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排序方式: 共有2456条查询结果,搜索用时 78 毫秒
1.
中青年脑梗塞患者的临床与病理   总被引:56,自引:0,他引:56  
目的 探讨中,青年人脑梗塞的病因。方法 将连续尸检确诊的脑梗塞病例中≤45岁患者的脑标本常规处理,以动脉为重点行肉眼及光镜下观察,并分析有关临床资料。结果 72例患者中≤45岁者7例,其中男6例,女1例,其中高血压,风湿性心脏病各2例,嗜烟,嗜酒中4例,病前1日酗酒1例。便塞灶相关动脉闭塞处管壁5例发现粥样斑块,3例发现炎症(1例与粥样斑并存)。5例粥样斑块血栓形成均位于基底动脉,4例病后2日内死  相似文献
2.
Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its topographic possibilitiesellipsis while science is the compass that keeps us from getting lost. -R. T. Bartus, Simple Words for Complex Lives, (c) 1998 In the nearly 20 years since the cholinergic hypothesis was initially formulated, significant progress has been achieved. Initial palliative treatments for Alzheimer's disease (AD) have proven beneficial and have gained FDA approval, the use of animal models for studying AD and other neurodegenerative diseases has achieved wider acceptance, and important insight into the potential causes and pathogenic variables associated with various neurodegenerative diseases continues to increase. This paper reviews the current status of the cholinergic hypothesis in the context of continuing efforts to improve upon existing treatments for AD and explores the role that animal models might continue to play. Using the benefit of hindsight, particular emphasis is placed on an analysis of the approaches, strategies, and assumptions regarding animal models that proved useful in developing the initial treatments and those that did not. Additionally, contemporary issues of AD are discussed within the context of the cholinergic hypothesis, with particular attention given to how they may impact the further refinement of animal models, and the development of even more effective treatments. Finally, arguments are presented that, despite the deserved enthusiasm and optimism for identifying means of halting the pathogenesis of AD, a clear need for more effective palliative treatments will continue, long after successful pathogenic treatments are available. This review, therefore, focuses on issues and experiences intended to: (a) facilitate further development and use of animal models for AD and other neurodegenerative diseases, and (b) accelerate the identification of newer, even more effective treatments.  相似文献
3.
山东省城市老年人睡眠障碍患病率的现况调查   总被引:33,自引:0,他引:33  
目的 探讨山东省城市老年人睡眠障碍的流行病学特点及其相关因素。方法 采用多级抽样的方法,于1997年3-6月对2003名≥65岁的山东省城市老年人进行调查,调查工具为睡眠行为与睡眠质量评定量表(SBQS),一般项目调查表等。结果 (1)资料完整者1805名(应答率为90.11%),有各种睡眠障碍者为1006例,患病率为55.73%;其中失眠为28.98%(523例),(2)男性的高声打鼾(196例,22.84%),睡眠呼吸暂停(18例,2.10%)和日间嗜睡(13例,1.52%)患病率高于女性(分别为85例,8.98%,9例,0.95%;2例,0.21%),而女性的不宁腿综合征(123例,12.99%)和夜间肌阵挛(137例,14.47%)患病率高于男性(分别为86例,10.02%;61例,7.11%)。(3)经Logistic回归分析,年龄大,文化程度低,丧偶和有躯体疾病的老年人睡眠障碍患病率高。(3)经Logistic回归分析,年龄大,文化程度低,丧偶和有躯体疾病的老年人睡眠障碍患病率高,。结论 山东省城市老年人中睡眠障碍比较多见,睡眠障碍的发生与性别,年龄,文化程度,婚姻状态和躯体疾病有关。  相似文献
4.
社区老年人认知功能变化及其预后的五年前瞻性研究   总被引:31,自引:0,他引:31  
目的 观察一个社区居住的老年人群体的认知功能随年龄变化的发生和发展速度,以及与预后的关系。方法 在北京市≥60岁的老年和55 ̄59岁的亚老年人群(在此统称老年人)中抽取一个样本,对其进行前瞻性研究,即分别于1992年和5年后检查认知功能。结果 基线调查时2047名老年人中有241人(11.8%)认知功能异常。随访发现,认知功能异常者5年死亡率42.9%,明显高于认知功能正常老人的死亡率(19.8%  相似文献
5.
Approximately three-quarters of epileptic patients seen in consultation by specialists can easily be assigned to one of the diagnostic categories of the International League against Epilepsy. When patient age is taken into account, such a distribution shows that partial epilepsy is more common than generalized epilepsy (62% versus 38%) in patients of all ages, especially in those over 15 years of age (78% versus 22%). In contrast, generalized epilepsy is more frequent in subjects under 15 than partial epilepsy (55% versus 45%). In this younger age group the rarity of partial epilepsy is primarily due to the infrequency of temporal lobe epilepsy (21% of cases, as opposed to 56% in subjects over 15), whereas both primary and secondary generalized epilepsy contribute to the frequency of generalized epilepsy in this group.  相似文献
6.
单纤维肌电图正常值的研究   总被引:27,自引:5,他引:22  
目的研究68名正常人单纤维肌电图颤抖(jiter)和纤维密度(FD)的正常值。方法用特殊的单纤维针电极测定上肢的伸指总肌和下肢的胫前肌的jiter和FD。结果Jiter与年龄有明显的相关性,随着年龄增长,jiter增宽,而与性别无明显的相关性;FD亦与年龄有关。结论该方法为检测神经肌肉接头处的功能和肌纤维再生情况的客观指标。  相似文献
7.
Highly polysialylated neural cell adhesion molecule (PSA-NCAM) is transiently expressed specifically in newly generated cells, and is important for migration and neurite outgrowth. To investigate the effect of aging on the migration of neural stem cell (NSC) after brain ischemia, the spatiotemporal expressions of immunoreactive PSA-NCAM were examined at 4 h or 1, 3 or 7 days after 90 min of middle cerebral artery occlusion (MCAO) in the young-adult or aged rats. In the sham control brain, PSA-NCAM staining was slightly observed both in dorsal and ventral parts of subventricular zone (SVZ) in the aged brain, but only in the dorsal part of SVZ in the young brain. After transient MCAO, immunoreactivity for PSA-NCAM increased in the number and the intensity in SVZ ipsilateral to MCAO in the young-adult brains and became the peak at 1 day, while that was at 3 days in the aged brains. These findings suggest that PSA-NCAM was located in different spatial distribution in normal condition between young and old rats. PSA-NCAM was induced after ischemia, and the temporal expression was also different after transient MCAO between young and older rats.  相似文献
8.
社区正常老年人和轻度认知功能损害老年人的随访研究   总被引:22,自引:0,他引:22  
目的了解社区正常和轻度认知功能损害(MCI)老年人的认知功能变化特点和转归。方法分别于2000年5月和2004年6月(时隔4年)对杭州市186名≥60岁老年人采用分层、分段、随机抽取方法进行调查。两次调查的程序和使用工具相同,采用美国精神障碍诊断与统计手册第4版进行诊断,用世界卫生组织老年认知功能评价成套神经心理测验(WHO-BCAI)进行测查。结果(1)在2000年调查时诊断为正常的127例中,4年后有97例(76.4%)正常(NC组),16例(12.6%)为MCI(MCI组),14例(11.0%)为痴呆(痴呆组);而2000年诊断为MCI的18例,4年后全部发展为痴呆。(2)与NC组比较,除性别外,MCI组的年龄大、教育水平低、从事体力劳动和不良婚姻事件多(P〈0.05和P〈0.01),痴呆组的年龄大和男性比例高(均P〈0.05和P〈0.01)。(3)WHO-BCAI测验,2004年与2000年比较,三组各项测验的成绩均有所下降(P〈0.01或P〈0.05),其中以痴呆组为著;而MCI组在听觉词汇学习第4次测验、语言能力测验(小标记测验)、视觉辨认测验(语义联系、视觉推理)、连线测验、注销测验(注销测验2和3)、运动测验和空间结构等项下降明显。结论老年期MCI患者的认知功能损害和功能下降呈进行性加重,主要表现为学习、近记忆能力、记忆再现、语义记忆、抽象思维能力、空间感知及执行功能受损。  相似文献
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10.
An epidemiologic study of epilepsy in school age children has been carried out in Modena, Italy, during the period 1968 to 1973. The prevalence of epileptics aged 5 to 14 years varied between 3.98% and 4.91%. The accession rate varied between 60 and 98 cases /100,000. The primary generalized epilepsies represent 30.8%, the epilepsies with rolandic spike foci 23.9%, the other types of partial epilepsy 42.1%, and the Lennox-Gastaut syndrome 3.2%. Of the 178 epileptics diagnosed during school age, 159 have been followed for at least 4 years, with recovery in 55% of the cases and tendency to improve in 24%.  相似文献
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