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目的:本研究旨在比较肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)患者手术治疗与手术后联合放疗的生存期,探讨手术后辅助放疗的可行性,为ICC的临床治疗提供依据。方法:提取美国The Surveillance,Epidemiology,and End Results(SEER)数据库2004至2015年间诊断为ICC患者的临床资料, 根据手术后是否放疗,将患者分为手术组(surgery)和手术后放疗组(radiation after surgery),采用Kaplan-Meier方法比较两组总体生存期(overall survival,OS)和肝癌特异性生存期(liver cancer specific survival,LCSS)的差异。在进行了1∶1倾向评分匹配(propensity score matching,PSM)之后,再次比较OS与LCSS的差异。然后进行亚组分析比较手术组与手术后放疗组的疗效。最后收集本院数据对数据库结果进行验证。结果:共有470例患者纳入研究,其中手术组患者410例,手术后放疗组患者60例。PSM前手术组与手术后放疗组的中位OS(19.00个月vs 26.00个月,P=0.268)和中位LCSS(19.00个月 vs 26.00个月,P=0.591)无明显差异,PSM后手术组与手术后放疗组的中位OS(25.50个月 vs 26.00个月,P=0.531)和中位LCSS(27.00个月 vs 26.00个月,P=0.302)亦无明显差异。在亚组分析中,手术后放疗并不是ICC患者总体生存的保护因素。本院数据结果与数据库结果一致。结论:ICC患者手术后辅助放疗相较于手术治疗并不会延长患者生存。  相似文献   
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BackgroundProsthetic choice for mitral valve replacement is generally driven by patient age and patient and surgeon preference, and current guidelines do not discriminate between different etiologies of mitral valve disease. Our objective was to assess and compare short- and long-term outcomes after mitral valve replacement among patients with biological or mechanical prostheses in the setting of severe ischemic mitral regurgitation.MethodsBetween 2000 and 2016, 424 patients underwent mitral valve replacement for severe ischemic mitral regurgitation at our institution, using biological prosthesis in 188 (44%) and mechanical prosthesis in 236 (56%). A 1:1 propensity score match (n = 126 per group) and inverse probability of treatment weighting were used to compare groups. Short-term outcomes included in-hospital mortality and other cardiovascular adverse events. Long-term outcomes included survival and hospital readmission for cardiovascular causes, stroke, and major bleeding.ResultsIn-hospital mortality and early postoperative adverse events were similar between groups in the propensity score match and inverse probability of treatment weighting cohorts. Overall long-term survival was similar at 5 and 9 years, but mechanical prosthesis recipients were more frequently readmitted to hospital for cardiovascular causes, including stroke and non-neurological bleeding in propensity score matching and inverse probability of treatment weighting analyses (all P values < .004). Type of prosthesis did not independently influence all-cause mortality (hazard ratio, 1.01; 95% confidence interval, 0.71-1.43; P = .959), but placement of a mechanical prosthesis was associated with increased risk of readmission for cardiovascular events (hazard ratio, 1.65; 95% confidence interval, 1.17-2.32; P = .004) among matched patients.ConclusionsThe type of prosthesis has no influence on long-term survival among patients with severe ischemic mitral regurgitation undergoing mitral valve replacement. There may be an increased risk of neurologic events and serious bleeding associated with mechanical prostheses.  相似文献   
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 目的 探讨冲击波疗法对训练伤所致冈上肌肌腱炎的疗效。方法 回顾性分析武警特色医学中心骨科收治的236例训练伤冈上肌肌腱炎的病例,其中非钙化冈上肌肌腱炎158例(非钙化组),钙化冈上肌肌腱炎78例(钙化组),均行同样参数冲击波治疗,对比两组治疗前,治疗后6、12个月视觉模拟评分(VAS)、Constant肩关节评分。结果 与治疗前相比,治疗后6、12个月,两组VAS评分均明显降低,肩关节Constant评分显增加,差异有统计学意义(P<0.05);且治疗后6、12个月,钙化组与非钙化组比较,VAS评分更低、Constant评分更高,差异有统计学意义(P<0.05)。结论 冲击波疗法能够明显缓解训练伤冈上肌肌腱炎的疼痛症状,提高患侧肩关节功能;且对钙化性冈上肌肌腱炎疗效更好。  相似文献   
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ObjectiveTo compare the effect of exercises and orthotics with orthotics alone on pain and hand function in patients with first carpometacarpal joint (CMC-1) osteoarthritis (OA) and to predict outcomes on pain and hand function of exercises and orthotics.DesignProspective cohort study with propensity score matching.SettingData collection took place in 13 outpatient clinics for hand surgery and hand therapy in The Netherlands.ParticipantsA consecutive, population-based sample of patients with CMC-1 OA (N=173) was included in this study, of which 84 were matched on baseline demographics and baseline primary outcomes.InterventionsExercises and orthotics versus orthotics alone.Main Outcome MeasuresPrimary outcomes included pain and hand function at 3 months, measured using visual analog scale (VAS, 0-100) and the Michigan Hand Outcomes Questionnaire (MHQ, 0-100).ResultsA larger decrease in VAS pain at rest (11.1 points difference; 95% confidence interval, 1.9-20.3; P=.002) and during physical load (22.7 points difference; 95% confidence interval, 13.6-31.0; P<.001) was found in the exercise + orthotic group compared to the orthotic group. In addition, larger improvement was found for the MHQ subscales pain, work performance, aesthetics, and satisfaction in the exercise + orthotic group. No differences were found on other outcomes. Baseline scores of metacarpophalangeal flexion, presence of scaphotrapeziotrapezoid OA, VAS pain at rest, heavy physical labor, and MHQ total predicted primary outcomes for the total exercise + orthotic group (N=131).ConclusionsNon-surgical treatment of patients with CMC-1 OA should include exercises, since there is a relatively large treatment effect compared to using an orthosis alone. Future research should study exercises and predictors in a more standardized setting to confirm this finding.  相似文献   
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