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肌张力障碍的治疗进展   总被引:1,自引:0,他引:1  
肌张力障碍(dystonia)最早由Oppenheim于1911年提出,用来命名一种以躯体扭曲,肌肉痉挛,伴有身体屈曲的奇异步态以及逐渐出现的持续固定的姿态畸形为特征的儿童起病的全身性肌张力障碍。一个世纪以来,肌张力障碍的  相似文献
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中药熏蒸对痉挛型脑瘫患儿的疗效观察   总被引:1,自引:1,他引:0  
目的 评估中药熏蒸对脑瘫患儿的临床疗效.方法 68例脑瘫患儿随机分为2组,对照组采有功能训练、小儿按摩、蜡疗、痉挛肌常规治疗, 观察组除常规治疗外加用中药熏蒸.结果 观察组总有效率(94.1%)明显高于对照组(88.2%), 前者与后者的关节活动度均有明显改善(P<0.05). 结论 中药熏蒸能有效改善痉挛型脑瘫患儿的运动功能、缓解肌肉痉挛,降低肌张力.  相似文献
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目的 评价注射用A型肉毒毒素改善脑卒中亚急性期和恢复期肌肉痉挛和活动功能的效果比较.方法 选择2013年6月~2016年1月在我院就诊的脑卒中患者86例,根据病史长短分为亚急性期组(<1个月)37例和恢复期组(≥1个月)49例,均接受肉毒毒素200 U肌肉注射,疗程4周,评价治疗后改良Ashworth量表(MAS)、改良Tardieu量表(MTS)、徒手肌力检查法(MMT)、被动关节活动度(PROM)、Barthel指数和Fugl-Meyer量表.结果 所有患者均顺利接受治疗,两组随访时间分别为26(22~30)d和29(24~31)d,组间比较差异无统计学意义(Z=1.332,P=0.307);亚急性期组治疗后肘部、腕部MAS评分较疗前改善(P<0.05),而恢复期组MAS无明显差异(P>0.05),亚急性期组均优于恢复期组(P<0.05);亚急性期组治疗后肘部R1、D和腕部R1、R2均有改善(P<0.05),恢复期组治疗后MTS中肘部R1、D和腕部R1较治疗前改善(P<0.05),亚急性期组腕部R1、R2优于恢复期组(P<0.05);亚急性期组治疗后MMT肘部外展较治疗前改善(P<0.05),其他指标无改善;亚急性期组PROM腕部外展、腕部活动度较治疗前改善(P<0.05),恢复期组各指标治疗后无明显改善(P>0.05),亚急性组腕部外展优于恢复期组(P<0.05);亚急性期组Barthel指数、Fugl-Meyer和恢复期Fugl-Meyer较治疗前升高(P<0.05),但组间比较差异均无统计学意义(P>0.05).结论 肉毒毒素能改善脑卒中亚急性期和恢复期肌肉痉挛和功能,但亚急性期治疗效果更明显.  相似文献
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目的对1例遗传性血管病、肾病、动脉瘤和肌肉痉挛(hereditary angiopathy with nephropathy, aneurysm and cramps,HANAC)综合征患者进行临床、病理及基因的分析. 方法收集患者病史、家族史,进行影像学检查、皮肤肾脏活检.对患者及家族成员进行COL4A1基因分析. 结果50岁女性患者,临床表现为脑白质病变、肾病、肌肉痉挛.皮肤活检可见小血管基底膜普遍性增厚,胶原组织增生.肾脏穿刺活检病理显示肾小球血管基底膜增厚,肾小管间质增生.COL4A1基因检测发现第1号外显子A1A/G杂合子突变,为起始密码子的突变. 结论 COL4A1基因第1号外显子起始密码子基因突变的临床表型为不典型的HANAC综合征.  相似文献
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BACKGROUND: Studies have shown that sensory transduction is a way to introduce needle sensation. OBJECTIVE: To observe the influence of electro-acupuncture at the "Zusanll" (ST 36) point on lower extremity motor function in various sensory disturbance patients with cerebral stroke. DESIGN, TIME AND SETTING: A randomized, controlled, clinical study was performed at the Department of Neurological Rehabilitation, China Rehabilitation Research Centre from September 2006 to June 2008. PARTICIPANTS: Patients with first-time cerebral infarction or hemorrhage, or with a stroke history, but no neurodysfunction (single damage), were selected for this study. The subjects were right-handed and disease state was stable. A total of 240 inpatients were randomly assigned to the following groups: electro-acupuncture (n = 124) and control (n = 116). The two groups were further assigned into sub-groups: no sensory disturbance, superficial sensory disturbance, deep sensory disturbance, and deep and superficial sensory disturbance. METHODS: On the basis of routine limb function training, the acupoint Zusanliwas utilized in all patients from the electro-acupuncture group. Perpendicular acupuncture was 3.0-4.0 cm deep. An electric acupuncture instrument was connected when patients developed the needle sensation, deqi. A stimulation pattern consisting of distant and dense waves of 50 Hz was used to elicit slight dorsal foot extension. Acupuncture was administered 5 times per week, 30 minutes per session, for 6 weeks in total. MAIN OUTCOME MEASURES: FugI-Meyer assessment (FMA) was used to evaluate lower extremity motor function; Ver.1.0 gait analysis to estimate gait (step frequency, step speed, and step scope); lower extremity Composite Spasticity Scale (CSS) to estimate muscle spastic degree. RESULTS: Following treatment, motor function improved in both groups. Compared with the control group, FMA score, step speed, step frequency, and step scope were increased in the electro-acupuncture group, but there was no difference in lower extremity CSS scores between the electro-acupuncture and the control groups (P 〉 0.05). Compared with the control group, Zusanli (ST 36) electro-acupuncture improved motor function indices as follows: FMA score, step frequency, step speed, and step scope of patients with no sensory disturbance (P 〈 0.05-0.01), step frequency of patients with superficial sensory disturbance (P 〈 0.05), and step frequency and step speed of patients with deep sensory disturbance (P 〈 0.05). CONCLUSION: Zusanfi (ST 36) electro-acupuncture effects on lower extremity motor function in stroke patients were improved with no muscle tone rise. Therefore, this form of treatment can be used in convalescent treatment, Moreover, effects were different according to various sensory disturbance types, which suggested that sensory input influenced acupuncture effects.  相似文献
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人体内存在CB1和CB2两种大麻素受体亚型,大麻素类药物主要作用于该受体途径,可缓解多发性硬化所致的肌肉痉挛、震颤、疼痛等症状,并通过抑制神经兴奋毒性及对免疫系统的调节作用起到神经保护作用。  相似文献
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