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1.
ObjectivesThe aim of this study was to test whether optical coherence tomographic (OCT) guidance would provide additional useful information beyond that obtained by angiography and lead to a shift in reperfusion strategy and improved clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) with early infarct artery patency.BackgroundAngiography is limited in assessing the underlying pathophysiological mechanisms of the culprit lesion.MethodsEROSION III (Optical Coherence Tomography–Guided Reperfusion in ST-Segment Elevation Myocardial Infarction With Early Infarct Artery Patency) is an open-label, prospective, multicenter, randomized, controlled study approved by the ethics committees of participating centers. Patients with STEMI who had angiographic diameter stenosis ≤ 70% and TIMI (Thrombolysis In Myocardial Infarction) flow grade 3 at presentation or after antegrade blood flow restoration were recruited and randomized to either OCT guidance or angiographic guidance. The primary efficacy endpoint was the rate of stent implantation.ResultsAmong 246 randomized patients, 226 (91.9%) constituted the per protocol set (112 with OCT guidance and 114 with angiographic guidance). The median diameter stenosis was 54.0% (IQR: 48.0%-61.0%) in the OCT guidance group and 53.5% (IQR: 43.8%-64.0%) in the angiographic guidance group (P = 0.57) before randomization. Stent implantation was performed in 49 of 112 patients (43.8%) in the OCT group and 67 of 114 patients (58.8%) in the angiographic group (P = 0.024), demonstrating a 15% reduction in stent implantation with OCT guidance. In patients treated with stent implantation, OCT guidance was associated with a favorable result with lower residual angiographic diameter stenosis (8.7% ± 3.7% vs 11.8% ± 4.6% in the angiographic guidance group; P < 0.001). Two patients (1 cardiac death, 1 stable angina) met the primary safety endpoint in the OCT guidance group, as did 3 patients (3 cardiac deaths) in the angiographic guidance group (1.8% vs 2.6%; P = 0.67). Reinfarction was not observed in either group. At 1 year, the rates of predefined cardiocerebrovascular events were comparable between the groups (11.6% after OCT guidance vs 9.6% after angiographic guidance; P = 0.66).ConclusionsIn patients with STEMI with early infarct artery patency, OCT guidance compared with angiographic guidance of reperfusion was associated with less stent implantation during primary percutaneous coronary intervention. These favorable results indicate the value of OCT imaging in optimizing the reperfusion strategy of patients with STEMI. (EROSION III: OCT- vs Angio-Based Reperfusion Strategy for STEMI; NCT03571269)  相似文献   
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目的探讨基于微信平台的延续护理在颈动脉狭窄患者行颈动脉支架植入术后的应用效果。方法选择2019年1月—2020年12月于浙江省台州医院行颈动脉支架植入术的120例颈动脉狭窄患者为研究对象,根据随机数字表法将其分为干预组和对照组,各60例。对照组患者应用常规出院指导及随访护理,干预组在对照组的基础上实施基于微信平台的延续护理。采用简易生活质量量表(SF-36)、家庭亲密度与适应性量表中文版(FACESⅡ-CV)、自制治疗依从性调查问卷调查两组患者的生活质量、家庭功能、治疗依从性。结果干预后,干预组患者SF-36评分及FACESⅡ-CV评分、治疗依从性均高于对照组,差异均有统计学意义(P<0.05)。结论基于微信平台的延续护理可以有效提升行颈动脉支架植入术后颈动脉狭窄患者的生活质量、治疗依从性及家庭功能,值得临床应用。  相似文献   
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Introduction and objectivesThe DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES.MethodsIndividual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach.ResultsWe included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI.ConclusionsThe incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.  相似文献   
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Approximately 7%-29% of patients with colorectal cancer present with colonic obstruction. The concept of self-expandable metal stent (SEMS) insertion as a bridge to surgery (BTS) is appealing. However, concerns on colonic stenting possibly impairing oncologic outcomes have been raised. This study aimed to review current evidence on the short- and long-term oncologic outcomes of SEMS insertion as BTS for left-sided malignant colonic obstruction. For short-term outcomes, colonic stenting facilitates a laparoscopic approach, increases the likelihood of primary anastomosis without a stoma, and may decrease postoperative morbidity. However, SEMS-related perforation also increases local recurrence and impairs overall survival. Moreover, colonic stenting may cause negative oncologic outcomes even without perforation. SEMS can induce shear forces on the tumor, leading to increased circulating cancer cells and aggressive pathological characteristics, including perineural and lymphovascular invasion. The conflicting evidence has led to discordant guidelines. Well-designed collaborative studies that integrate both oncologic outcomes and data on basic research (e.g., alteration of circulating tumors) are needed to clarify the actual benefit of colonic stenting as BTS.  相似文献   
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目的 评价内镜下全层切除(EFTR)食管及贲门近食管段巨大黏膜下肿瘤(SMTs)后应用全覆膜可回收金属支架处理巨大创面的疗效及安全性。方法 20例于2017年7月至2021年7月于复旦大学附属中山医院接受EFTR术并于术后放置全覆膜可回收支架的食管及贲门近食管段巨大SMTs患者,对其治疗效果、术后并发症等结果进行回顾性分析。结果 20例食管及贲门近食管段巨大SMTs患者接受EFTR术后出现应用常规内镜缝合技术无法完全修补及封闭的创面,均予置入全覆膜可回收金属支架,2-3周后取出,创面修复良好,未出现严重并发症。结论 全覆膜可回收金属支架在修补及封闭食管及贲门近食管段巨大SMTs行EFTR术后巨大创面安全有效。  相似文献   
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目的探讨胆总管结石患者采用内镜逆行胰胆管造影术(ERCP)取石后同期开展胆道支架置入术或开展经内镜鼻胆管引流术(ENBD),对于防范并发症的价值。 方法按照前瞻性研究原则,选择2017年4月至2019年1月新疆医科大学第一附属医院收治的338例胆总管结石患者,随机分为支架组(170例)与引流组(168例)。两组患者均行ERCP治疗,其中引流组术后同期开展ENBD,支架组患者术后开展胆道支架置入术,对比两组患者腹痛评分、并发症发生情况及预后。 结果两组患者术后均未合并严重出血、穿孔或病死,结石完全清除率差异无统计学意义。与支架组相比,引流组术中胰腺管插管次数,术后4 h血淀粉酶水平、高淀粉酶血症、急性胰腺炎以及并发症总发生率更高,差异有统计学意义(P<0.05),术后24、48、72 h不同时点腹痛测评分值居更高水平(P<0.05)。 结论对于胆总管结石行ERCP治疗的患者,术后予以ENBD、胆道支架置入术的结石完全清除效果对比无明显差异,但胆道支架置入术更能降低术后并发症风险、缓解腹痛症状,患者获益更多。  相似文献   
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目的探讨颅内动脉瘤Enterprise支架辅助弹簧圈栓塞后瘤腔和载瘤动脉的血流动力学改变。方法回顾性分析2021年3~8月Enterprise支架辅助弹簧圈栓塞治疗的24例颅内动脉瘤的临床资料。收集术前、术后即刻动脉瘤瘤腔和载瘤动脉处DSA数据的DICOM格式,导入OpenFOAM软件,应用计算流体力学数值模拟技术进行血流动力学分析,参数包括壁面剪切力(WSS)、均一化WSS(NWSS)、WSS分布梯度(WSSG)、流线方向WSSG(SWSSG)、归一化压力(NP)、剪切力震荡指数(OSI)。结果24例(24个动脉瘤)应用24枚Enterprise支架,术后即刻造影显示Raymond分级Ⅰ级18例,Ⅱ级6例。栓塞后WSS、NWSS、NWSS最小值、WSSG、WSSG最小值均明显升高(P<0.05),WSSG最大值明显降低(P<0.05)。结论Enterprise支架辅助弹簧圈栓塞治疗明显改变颅内动脉瘤的血流动力学,使载瘤动脉被重建、血流被重构,瘤腔内涡流减少或消失,血流形式由复杂转向简单。这些作用有助于瘤腔内血栓形成。  相似文献   
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PurposeTo compare the technical success of antegrade uteral stent (AUS) and retrograde ureteral stent (RUS) placements in patients with malignant ureteral obstruction (MUO) and to determine the predictors of technical failure of RUS.Materials and MethodsThis study retrospectively included 61 AUS placements (44 patients) performed under fluoroscopic guidance and 76 RUS placements (55 patients) performed under cystoscopic guidance in patients with MUO from January 2019 to December 2020. Technical success rates of the 2 techniques were compared using inverse probability of treatment weighting (IPTW) analysis. Logistic regression was used to identify predictive factors for technical failures.ResultsTechnical success was achieved in 98.4% of the AUS group and 47.4% of the RUS group. After stabilized IPTW, the technical success rate was higher in the AUS group than in the RUS group (adjusted risk difference, 49.4%; 95% confidence interval [CI], 35.4%–63.1%). The independent predictors for technical failure of the RUS procedure were age of ≥65 years (odds ratio [OR], 5.56; 95% CI, 1.73–21.27), ureteral orifice invasion (OR, 4.21; 95% CI, 1.46–13.46), and extrinsic cancer (OR, 15.58; 95% CI, 2.92–111.81).ConclusionsThe technical success rate of AUS placement was higher than that of RUS placement in patients with MUO. RUS failure was associated with age of ≥65 years, cancer with ureteral orifice invasion, and extrinsic ureteral obstruction.  相似文献   
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