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ObjectiveThe objective of this study was to reduce errors in a pathologic specimen with the help of a protocol systematizing the pathology specimen management process in the operating room.Materials and methodThis quasi-experimental study was carried out in the operating room unit of a research and training hospital. A protocol systematizing the process of specimen management in secure surgical pathology and prepared in light of the current literature was used as an intervention, and the effectiveness of the protocol was tested.ResultsIt was determined that the rate of adverse events decreased from .3226% (68 of 21,078) to .032% (6 of 18,706) after the protocol systematizing the surgical pathology specimen management process prepared by the researchers, and the protocol was found to be effective by 90% (P = .03).ConclusionBased on the data obtained in this study, we recommend the use of a pathologic specimen management protocol in the operating room.  相似文献   
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《Molecular therapy》2022,30(1):32-46
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PurposeWe have shown that “Click-to-sense” (CTS) assay based on the visualization of cancer cells by fluorescence probe targeted for acrolein is useful for differentiating between the malignant and benign lesions of the breast. In the present study, we aimed to apply CTS assay to the examination of the simulated surgical margins, being compared with frozen section (FS) analysis.Experimental designThe simulated surgical margin samples (n = 300) were obtained from 1 to 2 cm distant sites from the tumor margin in the mastectomy specimens of breast cancer patients, and divided into the training (n = 150) and validation (n = 150) set. The samples were subjected to CTS assay, subsequently to FS analysis and finally to permanent section (PS) analysis.ResultsDiagnostic accuracy of the CTS assay and FS analysis was evaluated in the examination of the simulated surgical margin status finally determined by the PS analysis. In the training set, sensitivity, specificity, and accuracy was 89.3%, 98.4%, and 96.7% for the CTS assay and 89.3%, 98.4%, and 96.7% for the FS analysis. In the validation set, sensitivity, specificity, and accuracy was 93.3%, 98.3%, and 97.3% for the CTS assay, and 93.3%, 99.2%, and 98.0% for the FS analysis.ConclusionsThe CTS assay is as accurate as the FS analysis in the examination of the simulated surgical margins in breast cancer patients, and it seems to have a potential to replace the FS analysis for the intra-operative examination of surgical margins in breast-conserving surgery since it is less labor-intensive and more time-saving than the FS analysis.  相似文献   
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术后胃排空延迟(DGE)是上消化道外科手术的一种常见并发症,尤其好发于远端胃切除和胰十二指肠切除手术(Whipple手术)后,其形成机制迄今不明,进一步明确其机制有助于该并发症的预防与处理。十二指肠的机械性扩张会反馈性地抑制胃排空。我们推测这一负反馈机制在近段空肠也存在,在空肠胀满或肠壁受到牵扯的情况下会导致胃排空抑制。激活这一负反馈抑制效应的外科因素众多,当用直径比较大的管形吻合器做空肠吻合时,吻合器的插入会使空肠黏膜发生环周蹭擦损伤,形成局部炎性反应。用吻合器做肠肠吻合会使输入襻形成扭转导致十二指肠和空肠扩张。此外,胃肠吻合口有可能存在轻微的张力,尤其在实施结肠前胃肠吻合时。肠黏膜的炎性水肿会造成空肠扩张,肠襻扭转会影响其通畅性,胃肠吻合口的张力会对空肠壁形成牵扯,这些因素都可能通过负反馈机制导致DGE。  相似文献   
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目的 探讨带感觉功能上臂外侧嵌合骨皮瓣修复手指复合组织缺损的临床效果。方法 回顾性研究。纳入2016年11月—2019年11月徐州仁慈医院手外科收治的6例手指软组织缺损伴指骨、神经缺损患者。其中,男4例,女2例;年龄33~61岁,平均47.3岁;右手2例,左手4例;拇、示、中指各1例,环指3例;皮肤缺损面积1.0 cm×1.5 cm~2.5 cm×3.0 cm,骨缺损长度1.5~2.5 cm。6例患者均采用一期创面彻底清创,创面缺损伴指骨、神经缺损先行异种皮覆盖创面,克氏针维持骨折稳定性;二期带感觉功能的上臂外侧嵌合骨皮瓣游离移植修复治疗,皮瓣设计面积1.5 cm×2.0 cm~3.0 cm×3.5 cm,骨瓣切取大小为1.5 cm×1.0 cm×1.0 cm~3.0 cm×1.5 cm×1.0 cm。术后采用中华医学会手外科学会手部功能评定标准评价手功能,英国医学研究委员会(BMRC)制定的感觉分级方法评价皮瓣感觉恢复效果,Michigan手部功能问卷评定标准评定患指外观满意度。结果 本组6例患者手术均顺利完成,术后随访3~7个月,平均13.5个月。6例皮瓣全部成活,骨折均愈合,骨瓣平均愈合时间3~6个月,平均3.5个月。供区直接缝合,创面均一期愈合。手部功能优5例、良1例,手指感觉恢复至S4级4例、S3+级2例,患指外观满意度评价非常满意1例、满意4例、一般1例。结论 带感觉功能的上臂外侧嵌合骨皮瓣游离移植,可同时修复手指软组织缺损和指骨缺损,对供区影响小,术后手指感觉功能恢复好,是修复手指复合组织缺损的备选方案之一。  相似文献   
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《Survey of ophthalmology》2023,68(5):940-956
Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of vision. Currently, there is no approved therapy to delay or prevent its progression, and clinical management is challenging because of phenotypic variability and high risk of complications after interventions; however, new insights into the molecular pathogenesis of AAK may help improve its management. Here, we review the current understanding about the pathogenesis and management of AAK. We highlight the biological mechanisms involved in AAK development with the aim to develop future treatment options, including surgical, pharmacological, cell therapies, and gene therapies.  相似文献   
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Background/PurposeA small number of Hirschsprung disease (HD) patients develop inflammatory bowel disease (IBD)-like symptoms after pullthrough surgery. The etiology and pathophysiology of Hirschsprung-associated IBD (HD-IBD) remains unknown. This study aims to further characterize HD-IBD, to identify potential risk factors and to evaluate response to treatment in a large group of patients.MethodsRetrospective study of patients diagnosed with IBD after pullthrough surgery between 2000 and 2021 at 17 institutions. Data regarding clinical presentation and course of HD and IBD were reviewed. Effectiveness of medical therapy for IBD was recorded using a Likert scale.ResultsThere were 55 patients (78% male). 50% (n = 28) had long segment disease. Hirschsprung-associated enterocolitis (HAEC) was reported in 68% (n = 36). Ten patients (18%) had Trisomy 21. IBD was diagnosed after age 5 in 63% (n = 34). IBD presentation consisted of colonic or small bowel inflammation resembling IBD in 69% (n = 38), unexplained or persistent fistula in 18% (n = 10) and unexplained HAEC >5 years old or unresponsive to standard treatment in 13% (n = 7). Biological agents were the most effective (80%) medications. A third of patients required a surgical procedure for IBD.ConclusionMore than half of the patients were diagnosed with HD-IBD after 5 years old. Long segment disease, HAEC after pull through operation and trisomy 21 may represent risk factors for this condition. Investigation for possible IBD should be considered in children with unexplained fistulae, HAEC beyond the age of 5 or unresponsive to standard therapy, and symptoms suggestive of IBD. Biological agents were the most effective medical treatment.Level of EvidenceLevel 4  相似文献   
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The era of geriatric surgery has arrived with increased global life expectancy. The need to optimize outcomes in this group of patients goes beyond traditional outcomes such as postoperative morbidity and mortality indicators. Recognizing risk factors that impact adverse surgical outcomes such as frailty and sarcopenia, individualizing optimization strategies such as prehabilitation and a multidisciplinary geriatric surgical service have been shown to improve postoperative outcomes and help the older surgical patient regain premorbid function and maintain quality of life. There needs to be a concerted effort to increase awareness of this increasingly important topic in practicing surgeons around the world to meet the challenges of the aging population.  相似文献   
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