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1.
Elin Rosen-Wetterholm Oscar Cavefors Björn Redfors Sven-Erik Ricksten Elmir Omerovic Christian L. Polte Jonatan Oras 《Acta anaesthesiologica Scandinavica》2023,67(6):746-754
Introduction
Left ventricular (LV) dysfunction is estimated to occur in 10%–25% of the general intensive care unit (ICU) population and is frequently seen as regional wall motion abnormalities (RWMAs). Although RWMA is mostly attributed to myocardial ischemia or infarction, some studies have suggested that nonischemic RWMA might also be prevalent. We sought to establish that RWMA can be seen in critically ill patients with normal coronary arteries and to explore reasons for RWMA in this population.Methods
In this retrospective study, data from the hospital angiography register and the ICU register were collated between 2012 and 2019. Patients were identified who underwent angiography in conjunction with their ICU stay and had RWMA on echocardiography. Patients were divided into either those with non-obstructed or those with obstructed coronary arteries. Cardiac magnetic resonance imaging (cMRI) examinations were reviewed if they had been performed on patients with non-obstructed coronaries.Results
We identified 53 patients with RWMA and non-obstructed coronary arteries and 204 patients with RWMA and obstructed coronary arteries. Patients with non-obstructed coronary arteries were more often female, younger, and had fewer cardiovascular risk factors. They less commonly had ST elevation, but more frequently had T-wave inversion or serious arrhythmias. Troponin levels were higher in patients with obstructed coronary arteries, but NT-proBNP was similar between the groups. There were no differences in risk-adjusted 90-day mortality between patients with non-obstructed versus obstructed coronary arteries (OR 1.21, [95% CI 0.56–2.64], p = .628). In those with non-obstructed coronary arteries, follow-up echocardiography was available for 38 patients, of whom 30 showed normalization of cardiac function. Of the 14 patients with non-obstructed coronary arteries on whom cMRI was performed, 7 had a tentative diagnosis of Takotsubo syndrome or myocardial stunning; 4 had a myocardial infarction (preexisting in 3 cases); 1 patient had acute myocarditis; 1 patient had post-myocarditis; and 1 patient was diagnosed with dilated cardiomyopathy.Conclusion
RWMA can be seen to occur in critically ill patients in the absence of coronary artery obstruction. Several conditions can cause regional hypokinesia, and cMRI is useful to evaluate the underlying etiology. 相似文献2.
《Journal of the American Medical Directors Association》2022,23(12):2015-2022.e5
ObjectivesTo explore formal and informal care costs in the last 3 months of life for people with dementia, and to evaluate the association between transitions to hospital and usual place of care with costs.DesignCross-sectional study using pooled data from 3 mortality follow-back surveys.Setting and ParticipantsPeople who died with dementia.MethodsThe Client Service Receipt Inventory survey was used to derive formal (health, social) and informal care costs in the last 3 months of life. Generalized linear models were used to explore the association between transitions to hospital and usual place of care with formal and informal care costs.ResultsA total of 146 people who died with dementia were included. The mean age was 88.1 years (SD 6.0), and 98 (67.1%) were female. The usual place of care was care home for 85 (58.2%). Sixty-five individuals (44.5%) died in a care home, and 85 (58.2%) experienced a transition to hospital in the last 3 months. The mean total costs of care in the last 3 months of life were £31,224.7 (SD 23,536.6). People with a transition to hospital had higher total costs (£33,239.2, 95% CI 28,301.8-39,037.8) than people without transition (£21,522.0, 95% CI 17,784.0-26,045.8), mainly explained by hospital costs. People whose usual place of care was care homes had lower total costs (£23,801.3, 95% CI 20,172.0-28,083.6) compared to home (£34,331.4, 95% CI 27,824.7-42,359.5), mainly explained by lower informal care costs.Conclusions and ImplicationsTotal care costs are high among people dying with dementia, and informal care costs represent an important component of end-of-life care costs. Transitions to hospital have a large impact on total costs; preventing these transitions might reduce costs from the health care perspective, but not from patients' and families' perspectives. Access to care homes could help reduce transitions to hospital as well as reduce formal and informal care costs. 相似文献
3.
目的 总结2021年7月20日郑州特大暴雨某医院危重症患者航空救援的经验,为航空救援实施提供参考。方法 通过成立航空救援筹备小组与航空救援团队,评估各病区收治能力及基础设施,构建航空救援转运流程,明确人员分工与接机转运路线,细化病情交接,并做好突发状况处置等安全管理工作。结果 本次航空救援共转运危重症患者24例,患者多患有冠状动脉粥样硬化性心脏病、心脏瓣膜病变、先天心脏病等心血管疾病。历经8.5 h的航空转运,所有患者均安全送达接收科室。结论 良好的航空救援基础、精细化的救援筹备、专业的航空转运团队、标准的航空转运流程、明确的人员分工与团队协作为此次航空救援提供了安全保障。 相似文献
4.
《Journal of microbiology, immunology, and infection》2022,55(2):291-299
Background/PurposeCytomegalovirus (CMV) viremia is associated with a higher mortality rate and prolonged intensive care unit (ICU) stay for critically ill patients. CMV infection causes transient but substantial immunosuppression for transplant recipients, increasing risk of fungal infection. The association between CMV viremia and invasive pulmonary aspergillosis (IPA) for critically ill patients is still unknown.MethodsWe retrospectively analyzed patients received bronchoalveolar lavage (BAL), galactomannan test, influenza survey and blood CMV viral load test in ICUs of a university hospital between April 2017 and May 2020. Independent risks for IPA were analyzed by multivariable logistic regression.ResultsA total of 136 patients were included. Twenty-one patients had IPA, 48 patients had CMV viremia and 22 patients had influenza. In a multivariable logistic regression model, patients with CMV viremia or influenza had higher IPA risk (adjusted odds ratio, 3.98 and 8.72; 95% CI, 1.26–12.60 and 2.64–28.82; p value = 0.019 and <0.001, respectively.). Patients with detectable CMV in BAL fluid did not have higher IPA risk (crude odds ratio, 0.95; 95% CI, 0.33–2.79; p value = 0.933). After stratifying patients by CMV viral load, the IPA risk is higher for patients with higher viral loads. There is an additive synergistic effect on IPA risk between CMV viremia and influenza infection.ConclusionFor critically ill patients, CMV viremia is an independent risk factor of IPA. Patients with higher blood CMV viral loads have a higher risk of IPA. CMV viremia and influenza have an additive synergistic effect for IPA risk in critically ill patients. 相似文献
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[目的]探究不同种类评分系统评价急诊科危重症预后的应用效果对比。[方法]将我院收治的184例急诊科危重症病人作为研究对象,采用不同的评分系统评价,分别是简单临床评分量表(SCS)、快速急诊内科评分量表(REMS)及急性生理与慢性健康状况评分Ⅱ量表(APACHEⅡ),对比三种评分系统标准与病人的死亡率情况、三种评分标准与病人的预后情况。[结果]在SCS评分中,>11分及6~11分病人死亡率明显高于0~5分病人死亡率,6~11分病人死亡率明显高于0~5分病人死亡率,差异具有统计学意义(P<0.05)。在REMS评分中,>16分及12~16分病人死亡率明显高于<11分病人死亡率,12~16分病人死亡率明显高于<11分病人死亡率,差异具有统计学意义(P<0.05)。在REMS评分中,>25分及15~24分病人死亡率明显高于<15分病人死亡率,15~24分病人死亡率明显高于<15分病人死亡率,差异具有统计学意义(P<0.05)。使用ROC曲线计算可见,SCS、REMS及APACHEⅡ评分的灵敏度分别为75.23%、76.44%、85.99%,特异度分别为71.23%、71.29%、80.62%,可见APACHEⅡ评分较SCS、REMS评分均具有更高的灵敏度以及特异性,差异具有统计学意义(P<0.05)。SCS、REMS评分相比灵敏度及特异性之间无明显差异(P>0.05)。[结论]SCS、REMS及APACHEⅡ这三种评分系统均能够在一定程度上对急诊科危重症病人的预后进行一定的判断,但结合急诊科危重症病人的实际情况分析,前二者的操作方法更加简便,通过对准确度进行判断可见,SCS评分具有更好的准确度,综合分析可见应用价值更高。 相似文献
10.
丁德正 《中国中医药现代远程教育》2021,(3)
慎察精神疾病患者之症象,准确辨证,若系正气虚匮或不足,予相应之扶正方药、针灸等主治或辅治之,收效颇佳。反之,审证不清,“实而误补,固必增邪”(《顾氏医镜》)。同时,宜鼓励患者多做活动锻炼,增强体质,提高正气,亦可谓一种较好的扶正辅助疗法。 相似文献