Micropapillary carcinoma of the parotid gland arising in mucinous cystadenoma

We describe a 45-year-old man who had a 2-year history of a slowly enlarging tumor in the left parotid gland. Histologically, the tumor was a mucinous cystadenoma with focal apocrine differentiation, which revealed a widespread invasive micropapillary adenocarcinoma component. A rim of lymphoid tissue surrounded the margins of the micropapillary carcinoma. The invasive micropapillary adenocarcinoma component was morphologically identical with the invasive micropapillary carcinoma of the mammary gland. The tumor is different from so-far recognized salivary gland tumor entities. Received: 25 October 1999 / Accepted: 13 June 2000     

Implications of micropapillary urothelial carcinoma variant on prognosis following radical cystectomy: A multi-institutional investigation

Purpose

To determine the association of micropapillary urothelial carcinoma (MUC) variant histology with bladder cancer outcomes after radical cystectomy.

不同病理亚型乳腺粘液癌的超声表现特征

目的探讨不同病理亚型乳腺粘液癌(MBC)的超声表现特征。方法选取39个MBC病灶,比较传统单纯性乳腺粘液癌(cPMBC)、乳腺粘液微乳头状癌(MUMPC)及混合型乳腺粘液癌(MMBC)的临床及超声表现特点,采用SPSS 23.0统计学软件对数据分析。结果MBC多表现为平行方位的低回声团块,少见液化及微钙化;cPMBC、MUMPC多呈椭圆形或分叶状,后方回声增强及伴侧方声影,前者多富血供,后者多乏血供;MMBC边缘多呈角状或蟹足状且乏血供,后方回声多无改变,少见侧方声影。三组癌的年龄、最大径、位置、纵横比、内部回声、微钙化、导管变化、血流Adler分级及阻力指数比较差异无统计学意义(P>0.5),cPMBC与MMBC的边缘、后方回声模式、侧方声影比较差异有统计学意义(P<0.0167),MMBC较cPMBC与MUMPC更易出现淋巴结转移(P<0.0167)。结论MBC的超声表现与其组织病理学特点相关,cPMBC、MUMPC与MMBC的声像特征各具特点。     

Micropapillary bladder cancer: Current treatment patterns and review of the literature

ObjectivesNo guidelines exist for the management of micropapillary bladder cancer (MPBC) and most reports of this variant of urothelial carcinoma are case series comprising small numbers of patients. We sought to determine current practice patterns for MPBC using a survey sent to the Society of Urologic Oncology (SUO) and to present those results in the setting of a comprehensive review of the existing literature.Materials and methodsA survey developed by the Translational Science Working Group of the Bladder Cancer Advocacy Network–sponsored Think Tank meeting was distributed to members of the SUO. The results from 118 respondents were analyzed and presented with a literature review.ResultsMost survey respondents were urologists, with 80% considering bladder cancer their primary area of interest. Although 78% of the respondents reported a dedicated genitourinary pathologist at their institution, there were discrepant opinions on how a pathologic diagnosis of MPBC is determined as well as variability on the proportion of MPBC that is clinically significant. Among them, 78% treat MPBC differently than conventional urothelial carcinoma, with 81% reporting that they would treat cT1 MPBC with upfront radical cystectomy. However, the respondents had split opinions regarding the sensitivity of MPBC to cisplatin-based chemotherapy, which affected utilization of neoadjuvant chemotherapy in muscle-invasive disease.ConclusionsThe management of MPBC is diverse among members of the SUO. Although most favors early cystectomy for cT1 MPBC, there is no consensus on the use of neoadjuvant chemotherapy for muscle-invasive MPBC.     

Mucocele-like tumor of the breast caused by ductal carcinoma in situ: a case report

A mucocele-like tumor (MLT) of the breast caused by clinging and micropapillary carcinoma in situ is reported. The tumor was a smooth-contoured mass located near the nipple in the lower inner quadrant of the left breast. Ultrasonography showed a cystic tumor and distended ducts. An aspiration specimen contained abundant mucinous material and a small amount of epithelial cell components, but was insufficient for cytological diagnosis. An excisional biopsy specimen disclosed multiple cysts containing mucin with extravasation into the stroma. Additional pathologic diagnosis using consecutive microscopic sections demonstrated ductal carcinoma in situ. Subcutaneous mastectomy was subsequently performed. Histopathologic findings in the resected and biopsy specimens indicated a diagnosis of MLT caused by widely spreading clinging and micropapillary ductal carcinoma in situ. The ductal epithelium of the MLT in an open biopsy specimen must be carefully examined using consecutive microscopic sections to detect occult DCIS.     

Rare histological subtype of invasive micropapillary carcinoma in the ampulla of Vater: A case report

BACKGROUNDCarcinoma of the ampulla of Vater is an uncommon ampullo-pancreatobiliary neoplasm, and the most common histological type is adenocarcinoma with a tubular growth pattern. Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma in several organs that is associated with lymph node metastasis and poor prognosis. IMPC was first described as a histological subtype of breast cancer; however, IMPC of the ampulla of Vater is extremely rare, with only three articles reported in the English literature.CASE SUMMARYWe have reported a case of IMPC of the ampulla of Vater in an 80-year-old man. Microscopically, the surface area of the carcinoma was composed of tubulopapillary structures mimicking intra-ampullary papillary-tubular neoplasm, and the deep invasive front area exhibited a pattern of IMPC. The carcinoma showed lymphatic invasion and extensive lymph node metastasis. The immunohistochemical study revealed mixed intestinal and gastric/pan-creatobiliary phenotypes.CONCLUSIONThis rare subtype tumor in the ampulla of Vater showed a histologically mixed phenotype and exhibited aggressive behavior.     

卵巢微乳头交界性浆液性肿瘤一例及文献复习

卵巢微乳头型浆液性交界性肿瘤（micropapillary serous borderline tumor,MPSC）是卵巢癌中非常罕见的一种病理类型,这种肿瘤不显示破坏性浸润生长,但可能与恶性行为有关,与无微乳头状结构的浆液性病变相比,双侧肿瘤、表面受累的频率更高,且盆腹腔浸润性种植的发生率更高,相当于非浸润性低级别浆液性癌。到目前为止对于MPSC的治疗仍没有明确的诊治规范或指南,微乳头结构对浆液性交界性卵巢肿瘤患者预后的影响目前仍存在争议。结合我院收治的1例伴有腹腔非浸润性种植的MPSC患者,主要对此疾病的治疗加以探讨,已期提高临床医师对本病治疗的进一步认识。