全文获取类型
收费全文 | 42969篇 |
免费 | 6220篇 |
国内免费 | 1776篇 |
专业分类
耳鼻咽喉 | 101篇 |
儿科学 | 620篇 |
妇产科学 | 404篇 |
基础医学 | 4442篇 |
口腔科学 | 136篇 |
临床医学 | 3797篇 |
内科学 | 3854篇 |
皮肤病学 | 216篇 |
神经病学 | 406篇 |
特种医学 | 1779篇 |
外国民族医学 | 74篇 |
外科学 | 5600篇 |
综合类 | 5992篇 |
现状与发展 | 6篇 |
一般理论 | 1篇 |
预防医学 | 1829篇 |
眼科学 | 78篇 |
药学 | 2779篇 |
25篇 | |
中国医学 | 1330篇 |
肿瘤学 | 17496篇 |
出版年
2024年 | 71篇 |
2023年 | 804篇 |
2022年 | 1424篇 |
2021年 | 2498篇 |
2020年 | 2434篇 |
2019年 | 1998篇 |
2018年 | 1838篇 |
2017年 | 1933篇 |
2016年 | 2017篇 |
2015年 | 2367篇 |
2014年 | 3254篇 |
2013年 | 3203篇 |
2012年 | 2533篇 |
2011年 | 2722篇 |
2010年 | 2035篇 |
2009年 | 1908篇 |
2008年 | 1978篇 |
2007年 | 2074篇 |
2006年 | 1998篇 |
2005年 | 1730篇 |
2004年 | 1416篇 |
2003年 | 1347篇 |
2002年 | 1115篇 |
2001年 | 974篇 |
2000年 | 790篇 |
1999年 | 643篇 |
1998年 | 472篇 |
1997年 | 448篇 |
1996年 | 371篇 |
1995年 | 362篇 |
1994年 | 266篇 |
1993年 | 249篇 |
1992年 | 216篇 |
1991年 | 204篇 |
1990年 | 144篇 |
1989年 | 126篇 |
1988年 | 127篇 |
1987年 | 116篇 |
1986年 | 110篇 |
1985年 | 126篇 |
1984年 | 102篇 |
1983年 | 66篇 |
1982年 | 87篇 |
1981年 | 88篇 |
1980年 | 45篇 |
1979年 | 44篇 |
1978年 | 31篇 |
1977年 | 20篇 |
1976年 | 22篇 |
1973年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Salvatore Greco Beatrice Bonsi Nicol Fabbri 《World Journal of Experimental Medicine》2022,12(5):104-107
Even if the relationships between nutrition and inflammatory bowel disease (IBD) remain underexplored, the current literature is providing, day by day, much more evidence on the effects of various diets in both prevention and treatment of such illnesses. Wrong dietary habits, together with other environmental factors such as pollution, breastfeeding, smoke, and/or antibiotics, are among the theoretical pathogenetic causes of IBD, whose multifactorial aetiology has been already confirmed. While some of these risk factors are potentially reversible, some others cannot be avoided, and efficient treatments become necessary to prevent IBD spread or recurrence. Furthermore, the drugs currently available for treatment of such disease provide low-to-no effect against the symptoms, making the illnesses still strongly disabling. Whether nutrition and specific diets will prove to effectively interrupt the course of IBD has still to be clarified and, in this sense, further research concerning the applications of such dietary interventions is still needed. 相似文献
2.
目的 通过研究明确苗药五藤膏外敷缓解胶原诱导性关节炎(CIA)大鼠关节局部炎症和骨破坏的机制,证实苗医外治就近驱邪的作用。方法 将70只Wistar大鼠随机分为空白组、模型组、苗药五藤膏高、中、低剂量组、扶他林组及IL-17阻断组,每组10只。除空白组外,其余6组均构建CIA模型,并给予相应的外敷治疗。观察大鼠一般情况,HE染色进行病理学分析,TRAP染色检测OC生成,ELISA检测各炎症因子的含量,RT-PCR和WB分别检测RANKL的基因及蛋白表达。结果 苗药五藤膏能改善CIA大鼠破骨细胞浸润及关节病理性结构,并降低RANKL蛋白、基因表达以及TNF-α、IL-1、IL-6、IL-17含量。结论 苗药五藤膏外敷剂对CIA大鼠的治疗机制可能与降低致炎因子的分泌,抑制RANKL及OC的表达相关。 相似文献
3.
目的:构建预测年轻乳腺癌患者生存情况的列线图,以期帮助临床诊疗。方法:收集SEER数据库中5 525例年轻乳腺癌患者的临床信息,通过单因素Log-rank检验和多因素Cox生存分析筛选出独立预后因素,用于构建预测患者3、5年总生存率(overall survival,OS)和癌症特异性生存率(cancer special survival,CSS)的列线图,将我院就诊的147例年轻乳腺癌患者作为验证集进行外部验证。结果:单因素和多因素分析结果显示,种族、病理类型、组织学分级、T分期、N分期、M分期、ER状态、HER-2状态、手术方式是与患者OS和CSS相关的独立危险因素,将这些因素纳入并建立预测患者OS和CSS的列线图模型。内部和外部验证结果显示模型具有良好的预测性能。基于建立的OS和CSS列线图模型对患者进行了风险分层,能够准确地将年轻乳腺癌患者分成预后有显著差异的三个风险亚组。结论:本研究构建的预测模型能较为准确的预测年轻乳腺癌患者的预后情况,为临床的诊疗提供科学依据。 相似文献
4.
Kely Paviani StevanatoRaíssa Bocchi PedrosoCatia Millene Dell AgnoloLander Dos SantosFernando Castilho PellosoMaria Dalva de Barros CarvalhoSandra Marisa Pelloso 《Asian Pacific journal of cancer prevention》2022,23(4):1117-1123
Objective: To perform a scoping review of the applicability of the Gail model in different countries for different ethnicities. Methods: The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist and search strategies based on the PICOS approach. The reviewed articles were included if they were published between 2013 and 2018 in English, Portuguese, or Spanish; were original articles available in full online; and described the use of the Gail model. The PubMed, Embase, and Web of Science data bases were searched. Results: A total of 38 articles eligible for analysis were identified, of which 16 used the Gail model to assess breast cancer risk in women, eight analyzed the applicability of this tool in their population, seven compared the tool and/or modified it according to the specific risk factors of their population, and seven cited the model in determining eligibility for chemoprevention. Conclusion: The Gail model has different applicabilities Greater effectiveness and breast cancer risk are found in developed countries. 相似文献
5.
《Value in health》2022,25(1):69-76
ObjectivesThere is limited knowledge about the cost patterns of patients who receive a diagnosis of de novo and recurrent advanced cancers in the United States.MethodsData on patients who received a diagnosis of de novo stage IV or recurrent breast, colorectal, or lung cancer between 2000 and 2012 from 3 integrated health systems were used to estimate average annual costs for total, ambulatory, inpatient, medication, and other services during (1) 12 months preceding de novo or recurrent diagnosis (preindex) and (2) diagnosis month through 11 months after (postindex), from the payer perspective. Generalized linear regression models estimated costs adjusting for patient and clinical factors.ResultsPatients who developed a recurrence <1 year after their initial cancer diagnosis had significantly higher total costs in the preindex period than those with recurrence ≥1 year after initial diagnosis and those with de novo stage IV disease across all cancers (all P < .05). Patients with de novo stage IV breast and colorectal cancer had significantly higher total costs in the postindex period than patients with cancer recurrent in <1 year and ≥1 year (all P < .05), respectively. Patients in de novo stage IV and those with recurrence in ≥1 year experienced significantly higher postindex costs than the preindex period (all P < .001).ConclusionsOur findings reveal distinct cost patterns between patients with de novo stage IV, recurrent <1-year, and recurrent ≥1-year cancer, suggesting unique care trajectories that may influence resource use and planning. Future cost studies among patients with advanced cancer should account for de novo versus recurrent diagnoses and timing of recurrence to obtain estimates that accurately reflect these care pattern complexities. 相似文献
6.
7.
《Diagnostic Histopathology》2022,28(3):156-160
Breast core biopsies are a standard component of the triple approach that includes clinical examination, imaging and tissue sampling. Conventional cores, diagnostic vacuum assisted biopsy and vacuum assisted excisions are established methods for sampling and managing breast lesions. It is important to be aware of the potential pitfalls in the technical handling and interpretation of the limited core biopsy samples. Here, we present a clinically oriented, well illustrated overview of the common diagnostic pitfalls based on the author's diagnostic and second opinion practice, emphasize the value of clinicopathological correlation and provide histological tips and clues with useful immunohistochemistry to aid the reporting pathologists in their daily interpretation of breast core biopsies. 相似文献
8.
Tomoe Koizumi PhD Yodo Sugishita MD PhD Yuki Suzuki-Takahashi MD PhD Kazuko Nara MA Tomoko Miyagawa MA Misako Nakajima MA Kouhei Sugimoto MD PhD Manabu Futamura MD PhD Tatsuro Furui MD PhD Yasushi Takai MD PhD Hiroshi Matsumoto MD PhD Hideko Yamauchi MD Shinji Ohno MD PhD Akemi Kataoka MD PhD Kiyotaka Kawai MD PhD Eisuke Fukuma MD PhD Hiroko Nogi MD PhD Koichiro Tsugawa MD PhD Nao Suzuki MD PhD 《Cancer》2023,129(16):2568-2580
9.
目的评估并比较基于不同机器学习算法建立的乳腺癌超声影像组学预测模型的诊断性能。 方法回顾性收集2017年1月至2019年4月就诊皖南医学院第一附属医院、有明确病理结果的乳腺肿块病例828例,以2018年8月31日为节点将其分为训练集(526例)和验证集(302例),提取肿块的超声影像组学特征并进行特征筛选,运用k最近邻(kNN)、逻辑回归(LR)、朴素贝叶斯(NB)、随机森林(RF)和支持向量机(SVM)5种机器学习算法分别建立预测模型,使用重复交叉验证方法做内部验证,计算比较各模型的敏感度、特异度、阳性预测值(PPV)和阴性预测值(NPV),并实施外部验证,绘制ROC曲线并比较ROC曲线下面积(AUC)以评价模型的鉴别诊断性能,绘制校准曲线评价模型校准度。 结果从提取的109个影像组学特征中筛选出19个特征建立了5种机器学习算法模型。在内部验证中,5种模型的敏感度、特异度、PPV、NPV比较,总体差异均有统计学意义(P均<0.001)。LR模型的特异度、PPV、NPV中位数分别为0.769、0.816、0.778,3项指标均高于其他4种模型;敏感度中位数为0.824,高于kNN、RF和SVM模型。此外,SVM模型的特异度、PPV、NPV中位数分别为0.706、0.774、0.759,虽均低于LR模型,但均高于其他3种模型。在外部验证中,LR、SVM、RF、kNN和NB的AUC依次为0.890、0.832、0.821、0.746和0.703,其中LR与SVM的AUC差异有统计学意义(P=0.012);此外,各模型在校准性能上表现并不一致,LR和SVM模型的校准曲线显示乳腺癌实际概率与预测概率之间的一致性较好。 结论以超声影像组学特征为基础,运用不同机器学习算法建立的乳腺癌超声预测模型,均表现出较高的诊断性能,其中LR模型表现最为突出;选择合适的机器学习算法有助于进一步提高预测模型的诊断性能,提供更加准确的量化预测结果。 相似文献
10.
《The Journal for Nurse Practitioners》2022,18(2):140-146
Early detection and improved treatments for breast cancer are increasing survival rates, thereby growing the number of survivors to almost 4 million in the United States. Continuing care after treatment is frequently provided in primary care. Evidence-based care includes a history review, physical examination, and imaging for recurrence and new cancers, along with health maintenance and health promotion. Additionally, survivors often experience long-term side effects from their disease and/or treatment, affecting health and quality of life. This article provides a synopsis of breast cancer treatment-related side effects and current evidence-based guidelines to assist the primary care provider caring for survivors. 相似文献