首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   17篇
  免费   0篇
妇产科学   1篇
基础医学   3篇
临床医学   1篇
内科学   2篇
特种医学   1篇
外科学   5篇
综合类   1篇
预防医学   2篇
药学   1篇
  2023年   2篇
  2021年   1篇
  2020年   1篇
  2018年   4篇
  2016年   1篇
  2015年   1篇
  2014年   1篇
  2013年   2篇
  2012年   1篇
  2011年   2篇
  2003年   1篇
排序方式: 共有17条查询结果,搜索用时 78 毫秒
1.
Changes in intestinal microbiome and barrier function are critical in the development of alcohol-related liver disease (ALD). Here, we determined the effects of a one-week alcohol withdrawal on parameters of intestinal barrier function in heavy drinkers with ALD in comparison to healthy non-drinkers (controls). In serum samples of 17 controls (m = 10/f = 7) and 37 age-matched ALD patients (m = 26/f = 11) undergoing a one-week alcohol withdrawal, markers of liver health and intestinal barrier function were assessed. Liver damage, e.g., fibrosis and hepatic steatosis, were assessed using FibroScan. Before alcohol withdrawal, markers of liver damage, lipopolysaccharide binding protein (LBP) and overall TLR4/TLR2 ligands in serum were significantly higher in ALD patients than in controls, whereas intestinal fatty acid binding protein (I-FABP) and zonulin protein concentrations in serum were lower. All parameters, with the exception of LBP, were significantly improved after alcohol withdrawal; however, not to the level of controls. Our data suggest that one-week of abstinence improves markers of intestinal barrier function and liver health in ALD patients.  相似文献   
2.
Background: An understanding of the factors that influence intestinal wall integrity during the transition from fetal to neonatal life is important to elucidate and minimize potential contributions to the development of intestinal pathologies in vulnerable newborns.

Objective: To assess the factors affecting intestinal wall integrity of late preterm and term newborns at birth.

Methods: The concentrations of serum intestinal fatty acid-binding protein (I-FABP) as biomarker of intestinal wall injury, superoxide dismutase (SOD), and glutathione peroxidase (Gpx) as parameters of oxidative stress, and blood gas analyses were measured in the arterial cord blood of 80 newborns, delivered by spontaneous vaginal delivery (labor group) or elective cesarean delivery (non-labor group).

Results: Compared with the non-labor group, I-FABP, SOD, and Gpx levels were significantly higher in the labor group. I-FABP concentration was inversely correlated with pH and BE and positively correlated with SOD and Gpx concentrations, second stage of labor duration, and active pushing time.

Conclusions: This study demonstrates that oxidative stress at birth and prolonged second stage of labor may lead to the intestinal injury, which is reflected in increased serum concentration of I-FABP.  相似文献   

3.
4.
目的探讨盐酸戊乙奎醚对围体外循环期患者血浆肠型脂肪酸结合蛋白(I-FABP)和D-乳酸浓度的影响。方法 40例拟在体外循环下行心脏瓣膜置换术患者,随机分为盐酸戊乙奎醚(P组)和对照组(C组),每组各20例。P组体外循环前10 m in颈内静脉注射盐酸戊乙奎醚0.05 mg/kg,对照组给予等容量生理盐水。分别于体外循环前(T1)、主动脉开放10 m in(T2)、停体外循环即刻(T3)、术后2 h(T4)、术后6 h(T5)、术后18 h(T6)采取中心静脉血标本,测定血浆I-FABP和血浆D-乳酸浓度。结果 T1时点两组患者血浆I-FABP和D-乳酸浓度的差异均无统计学意义(P〉0.05);与C组比较,P组转流开始后及术后各时点血浆I-FABP浓度均降低,其中T2~T5时点与C组的差异有统计学意义(P〈0.05);P组患者血浆D-乳酸浓度在转流后及术后各时点均较降低,其中T3、T4时点与C组的差异有统计学意义(P〈0.05)。结论预先给予盐酸戊乙奎醚0.05 mg/kg可降低围体外循环期患者血浆I-FABP和D-乳酸浓度,对肠黏膜屏障功能具有保护作用。  相似文献   
5.
6.

Background

In recent years several potential biochemical markers have been evaluated to facilitate a reliable diagnosis of necrotizing enterocolitis (NEC), but none have made progress to clinical routine. We performed a comparative assessment in premature infants to evaluate the diagnostic value of the routinely available cytokine interleukin (IL)-8, and two promising experimental biomarkers, the gut barrier proteins liver fatty acid binding protein (L-FABP) and intestinal fatty acid binding protein (I-FABP), respectively, for the diagnosis of NEC.

Methods

IL-8, L-FABP, and I-FABP concentrations were analyzed in the serum of 15 infants with NEC and compared with 14 gestational age-matched infants serving as a control group.

Results

Serum concentrations of I-FABP, L-FABP and IL-8 were significantly higher in infants with NEC compared with controls. IL-8 showed the highest diagnostic value with an area under the curve of 0.99, followed by L-FABP and I-FABP. In addition we found a significant correlation between IL-8 and both FABPs in infants with NEC.

Conclusion

Our results further advocate the possible role of IL-8 as a specific marker for NEC. The diagnostic value of IL-8 seems to be superior to I-FABP, and similar to L-FABP. The routinely availability facilitates IL-8 as a possible candidate for further clinical investigations.  相似文献   
7.

Background/purpose

Serum Intestinal Fatty-Acid Binding Protein (I-FABP) is a useful marker of bowel necrosis in pediatric intussusception. The aim of this study is to determine the sensitivity of this marker and correlate it with length of necrosed small bowel.

Methods

A single-centre prospective study of 50 children presenting to Lagos University Teaching Hospital, Nigeria, in whom a diagnosis of intussusception was made over 1 year was completed. Additionally, 25 age- and sex-matched controls (day case surgery) were recruited. They were grouped into three: 25 children with necrotic bowel, 25 without bowel necrosis, and 25 controls. The serum IFABP levels were compared between the cohorts with confirmed bowel necrosis at surgery and those with no necrosis, as well as controls. The cut-off values for the diagnosis of bowel necrosis were calculated using a receiver operating characteristic curve (ROC). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.

Results

Twenty-five children were diagnosed with necrotic intussusception whose serum IFABP immunoassay has significantly higher median compared with those without necrosis and controls (2056.0 ng/ml vs. 943.0 ng/ml and 478.0 ng/ml P = 0.0002). Using a cut-off value of 1538 ng/ml, the sensitivity, specificity, PPV, and NPV were 64%, 88%, 84%, and 71%, respectively. I-FABP titer greater than 1538 ng/ml was found to have higher likelihood of necrotic bowel (p = 0.002; odds ratio 13.04; 95% confidence interval; 0.618–0.891).

Conclusion

Serum I-FABP is moderately sensitive for discriminating between bowel necrosis, and it predicts increased likelihood of bowel resectability in intussusception.

Level of evidence

Level II – Development of diagnostic criteria in a consecutive series of patients and a universally applied “gold standard”.  相似文献   
8.
9.
ObjectivesThe study aimed to examine if the α-diversity and relative abundance of the gastrointestinal bacterial taxa is associated with the response magnitude of markers characteristic of exercise-induced gastrointestinal syndrome in response to exertional-heat stress.DesignCross-sectional.MethodsTwenty-two endurance-trained athletes completed 2 h running at 60% V.O2max in hot ambient conditions (35.2 °C, 25% relative humidity). Faecal samples were collected pre-exercise to determine bacterial taxonomy by 16S rRNA amplicon sequencing (Illumina MiSeq platform). Data were processed using the QIIME2 pipeline (v2019.1) establishing taxonomic classification with >95% confidence using SILVA. Pre- and post-exercise blood samples were used to determine plasma I-FABP and cortisol concentrations, and systemic inflammatory response profile. Markers of physiological and thermoregulatory strain, and gastrointestinal symptoms were measured every 10 min during exercise. Associations were determined by partial correlation controlled for body mass variables.ResultsPositive associations between Tenericutes (r(18) = 0.446, p = 0.049) and Verrucomicrobia (r(18) = 0.450, p = 0.046) phylum, Akkermansiaceae (r(18) = 0.486, p = 0.030) and Ruminococcaceae (r(18) = 0.449, p = 0.047) family and aligned genus groups with I-FABP were observed. Whilst, associations between Faecalibacterium (r(12) = 0.668, p = 0.009) and Ruminoclostridium-9 (r(12) = −0.577, p = 0.031) genus with systemic inflammatory profile were observed. Association between bacterial phyla, family, and genus groups were also observed for gastrointestinal symptoms and markers of thermoregulatory strain (r(18) >0.400, p < 0.05).ConclusionsThe relative abundance of several commensal bacterial groups showed modest favourable (i.e., low perturbations) or detrimental associations with the magnitude of gastrointestinal integrity perturbations and symptoms, and potentially influences body temperature change, in response to exertional-heat stress.  相似文献   
10.
Treatment of mice with high sublethal doses of cholera entero-exotoxin, or chol-eragen, given i.v. on days 4 and 6 post-coitum, i.e., around the time of nidation, decreases or suppresses pregnancy in females of 3 different strains of mice. Our studies reveal that the toxin interferes with embryonic growth and development after day 7 post-coitum, producing complete embryo resorption sometime between days 9 and 11 post-coitum.

Studies of plasma progesterone reveal normal or slightly elevated levels on day 7 post-coitum and a marked decrease on day 9 post-coitum in toxin-treated mice, indicating that failure of the corpus luteum occurs sometime between these two days. Exogenous progesterone during this period partially or totally prevents the abortifo-cient effect of the toxin, at least until day 9 post-coitum

In the period preceding abortion, treated mice may show a slight increase in frequency of pregnancy or number of implants per mouse, probably related to an initial but transitory stimulation of the corpus luteum by the toxin. A similar tendency was observed in mice treated with low doses of this substance by i.p. injection, suggesting that low doses of toxin might improve reproductive performance.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号