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黄芩汤出自《伤寒论》,原文用于治疗下利。笔者曾跟师黄煌教授学习经方,根据黄煌老师经验结合个人体会,以唇红、眼睑充血、肛门灼热等黏膜充血为抓手,采用黄芩汤治疗不孕,黄芩汤合百合地黄汤治疗蛋白尿、血尿,黄芩汤加黄柏治疗热痹,黄芩汤原方治疗痛经等均取得了较好的疗效,本方值得进一步深入研究。 相似文献
4.
《The African Journal of Urology》2014,20(3):158-160
Gestational choriocarcinoma (GC) belongs to a group of gestational trophoblastic tumors. This rare tumor has a great metastatic potential and thus requires an early and adapted treatment. Herein We report a case of GC in a 35-year-old patient who presents with hematuria from a renal metastasis. Clinical improvement was noted after nephrectomy and chemotherapy. This observation underlines the importance of the dosage of the beta-HCG and the polymorphic clinical presentation of gestational choriocarcinoma. 相似文献
5.
Teresa K. Chen Christine Murakami Rebecca L. Manno Duvuru Geetha 《Seminars in arthritis and rheumatism》2014
Objectives
Hematuria is considered a marker of active renal disease in ANCA-associated glomerulonephritis (ANCA-GN) with induction immunosuppression often continued until hematuria has resolved. We aim to determine whether longer hematuria duration is associated with lower estimated glomerular filtration rate (eGFR) at 1 year.Methods
We conducted a retrospective study of 55 patients with biopsy-proven ANCA-GN. Linear regression models were constructed to determine predictors of eGFR at 1 year. The primary exposure was hematuria (>5 rbc/hpf) duration, defined as <90 days vs. ≥90 days following renal biopsy. Covariates included age, gender, ANCA type, baseline eGFR, and baseline proteinuria.Results
Mean age at diagnosis was 58 years (53% male, 80% Caucasian, 38% PR3-ANCA, and 45% MPO-ANCA). At baseline, all patients had hematuria, 95% had proteinuria, and mean serum creatinine was 3.1 [standard deviation (SD) = 2.3] mg/dL. Overall, 93% were treated with steroids in combination with either cyclophosphamide or rituximab. Mean hematuria duration was 92 (SD = 77) days with 34 (62%) patients having hematuria resolution within 90 days. Older age and lower baseline eGFR were associated with lower eGFR at 1 year (p = 0.03 and p < 0.001, respectively). Hematuria resolution (<90 days vs. ≥90 days) was not predictive of eGFR at 1 year (p = 0.93).Conclusions
In ANCA-GN, hematuria duration does not predict eGFR at 1 year. Our findings provide support that among individuals who are otherwise considered to be in clinical remission, the persistence of hematuria should not delay transition from induction to maintenance immunosuppression. 相似文献6.
肾小球性血尿病机复杂,临证表现繁多,但总以阴虚生热者为主。邵老在重视本虚,强调阴虚病机在血尿中作用的同时,也注重气、血、水在本病演变中的作用。邵老认为,肾性血尿虽与阴虚有关,但血瘀、水湿却贯穿于疾病之始终,遣方用药时,在阴虚的基础上,以"滋阴清热,凉血止血"为大法自拟"血尿方",并灵活运用"活血、理气、行水"之法,环环相扣,随证加减,用之临床疗效卓著。 相似文献
7.
Krauss T Frauenfelder T Strebel RT Birzele J Scheffel H Seifert B Marincek B Goerres GW 《European journal of radiology》2012,81(3):417-422
Objectives
To compare the impact of unenhanced and contrast-enhanced multi-detector computed tomography (MDCT) for the detection of urinary stones and urinary obstruction in patients with suspected renal colic.Methods
95 patients with suspected renal colic underwent a three-phase MDCT for evaluation of the urinary tract. The unenhanced scan and the multiphase examination were reviewed retrospectively by two radiologists for the characterization of urinary stones and signs of obstruction. Results of unenhanced MDCT were compared with those obtained during the second review of the entire multiphase examination.Results
Overall diagnosis of urinary stones revealed an accuracy of 97.0% for unenhanced, and 98.9% for multiphase MDCT with a significant difference between both protocols (mixed-effects logistic regression: odds ratio 3.3; p = 0.019). With 3 versus 15 false positive ratings, multiphase MDCT was superior to unenhanced MDCT for the diagnosis of urinary stones.There was no significant difference in detecting signs of obstruction. Inter-reader agreement for overall stone detection was excellent on both unenhanced (kappa 0.84) and multiphase (kappa 0.88) MDCT.Conclusion
Contrast-enhanced multiphase MDCT offers distinct advantages compared to an unenhanced approach for the assessment of urinary stone disease, and therefore should be considered as a complementary examination for patients with inconclusive findings. 相似文献8.
Yanjie Xu Ye-Hwan Kim Pildu Jeong Xuan-Mei Piao Young Joon Byun Ho Won Kang Won Tae Kim Jong-Young Lee Isaac Y. Kim Sung-Kwon Moon Yung Hyun Choi Seok Joong Yun Wun-Jae Kim 《Urologic oncology》2019,37(1):86-96
Background
Urinary cell-free DNA (ucfDNA) has great potential as a “liquid biopsy” for use in diagnosis of urological cancers. In this study, we compared ucfDNA gene expression levels between patients with bladder cancer (BC) and those with hematuria, and determined whether they could be used as a noninvasive urine-based marker.Methods
The study cohort of 355 patients included a screening group (40 BC and 41 hematuria controls) and a validation cohort (149 BC and 125 hematuria controls). Expression levels ratios of 1 up-regulated gene (IQGAP3) to those of 7 down-regulated genes were examined in ucfDNA in the screening group to identify ratios that differed significantly between BC and hematuria patients. IQGAP3/BMP4 and IQGAP3/FAM107A ratios were selected and combined to develop a discriminant score (DS) index, which was tested in the validation cohort. Receiver operating characteristic curves and areas under the curve were calculated to evaluate the performance of the DS index.Results
IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were both significantly higher in BC patients than in hematuria patients (both P < 0.001). The DS index had an area under the curve of 0.862, a sensitivity of 71.0%, a specificity of 88.6%, a positive predictive value of 90.3%, and a negative predictive value of 67.2%.Conclusions
Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were significantly higher in patients with BC than in those with hematuria. The DS index exhibits good diagnostic performance as a noninvasive biomarker. 相似文献9.
Melania Guerrero-Hue Alfonso Rubio-Navarro Ángel Sevillano Claudia Yuste Eduardo Gutiérrez Alejandra Palomino-Antolín Elena Román Manuel Praga Jesús Egido Juan Antonio Moreno 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(1):13-26
Haemoglobin and myoglobin are haem proteins that play a key role as they help transport oxygen around the body. However, because of their chemical structure, these molecules can exert harmful effects when they are released massively into the bloodstream, as reported in certain pathological conditions associated with rhabdomyolysis or intravascular haemolysis. Once in the plasma, these haem proteins can be filtered and can accumulate in the kidney, where they become cytotoxic, particularly for the tubular epithelium, inducing acute kidney failure and chronic kidney disease. In this review, we will analyse the different pathological contexts that lead to the renal accumulation of these haem proteins, their relation to both acute and chronic loss of renal function, the pathophysiological mechanisms that cause adverse effects and the defence systems that counteract such actions. Finally, we will describe the different treatments currently used and present new therapeutic options based on the identification of new cellular and molecular targets, with particular emphasis on the numerous clinical trials that are currently ongoing. 相似文献
10.
《The Surgical clinics of North America》2016,96(3):503-515