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1.
<正>肿瘤是严重危害人类健康的疾病之一,流行病学数据显示,2018年全球约有1 810万肿瘤新发病例以及960万肿瘤死亡病例;肿瘤的发病率和死亡率在全球范围内迅速增长,其难治性及危害性使得肿瘤成为全球最重要的生命科学领域之一[1]。细胞死亡方式的研究对于肿瘤有重要意义,如细胞凋亡的发现对肿瘤细胞的清除及肿瘤治疗学产生了巨大影响,但单一方式的治疗常常伴随耐药性的产生[2-4];与此同时,诱导肿瘤细胞其它死亡形式在临床抗肿瘤治疗中也发挥重要的作用[5]。 相似文献
2.
《Presse medicale (Paris, France : 1983)》2020,49(2):103909
Interstitial lung disease (ILD) in children (chILD) is a heterogeneous group of rare respiratory disorders that are mostly chronic and associated with high morbidity and mortality. The pathogenesis of the various chILD is complex and the diseases share common features of inflammatory and fibrotic changes of the lung parenchyma that impair gas exchanges. The etiologies of chILD are numerous. In this review, we chose to classify them as ILD related to exposure/environment insults, ILD related to systemic and immunological diseases, ILD related to primary lung parenchyma dysfunctions and ILD specific to infancy. A growing part of the etiologic spectrum of chILD is being attributed to molecular defects. Currently, the main genetic mutations associated with chILD are identified in the surfactant genes SFTPA1, SFTPA2, SFTPB, SFTPC, ABCA3 and NKX2-1. Other genetic contributors include mutations in MARS, CSF2RA and CSF2RB in pulmonary alveolar proteinosis, and mutations in TMEM173 and COPA in specific auto-inflammatory forms of chILD. However, only few genotype-phenotype correlations could be identified so far. Herein, information is provided about the clinical presentation and the diagnosis approach of chILD. Despite improvements in patient management, the therapeutic strategies are still relying mostly on corticosteroids although specific therapies are emerging. Larger longitudinal cohorts of patients are being gathered through ongoing international collaborations to improve disease knowledge and targeted therapies. Thus, it is expected that children with ILD will be able to reach the adulthood transition in a better condition. 相似文献
3.
The Hierarchical Clustering of Clinical Psychology Practicum Competencies: A Multisite Study of Supervisor Ratings 下载免费PDF全文
Craig J. Gonsalvez Frank P. Deane Russell Blackman Michael Matthias Roslyn Knight Yasmina Nasstasia Alice Shires Kathryn Nicholson Perry Christopher Allan Vida Bliokas 《Clinical psychology》2015,22(4):390-403
Competency evaluation rating forms are widely used to assess a range of global and specific psychology practitioner competencies during and at the end of clinical placements. Surprisingly, there is little research examining the dimensional structure or the hierarchical clustering of items on these ratings. The current, multisite study examined supervisor ratings of clinical psychology trainees (N = 204) on the Clinical Psychology Practicum Competencies Rating Scale (CΨPRS). Based on the proximity criterion chosen, hierarchical clustering yielded either nine clusters or four super clusters: Good Practitioner Attributes and Conduct, Scientist Practitioner and Professional Management, Assessment and Intervention, and Psychological Testing. The study also tracked the developmental trajectory of competency attainment. CΨPRS ratings differentiated groups between early but not between later stages of training. Measurement issues and implications for training and practice are discussed. 相似文献
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《Vaccine》2022,40(30):4017-4025
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the coronavirus disease 2019 (COVID-19) has afflicted hundreds of millions of people in a worldwide pandemic. Several safe and effective COVID-19 vaccines are now available. However, the rapid emergence of variants and risk of viral escape from vaccine-induced immunity emphasize the need to develop broadly protective vaccines. A recombinant plant-derived virus-like particle vaccine for the ancestral COVID-19 (CoVLP) recently authorized by Canadian Health Authorities and a modified CoVLP.B1351 targeting the B.1.351 variant (both formulated with the adjuvant AS03) were assessed in homologous and heterologous prime-boost regimen in mice. Both strategies induced strong and broadly cross-reactive neutralizing antibody (NAb) responses against several Variants of Concern (VOCs), including B.1.351/Beta, B.1.1.7/Alpha, P.1/Gamma, B.1.617.2/Delta and B.1.1.529/Omicron strains. The neutralizing antibody (NAb) response was robust with both primary vaccination strategies and tended to be higher for almost all VOCs following the heterologous prime-boost regimen. 相似文献
7.
目的 探讨晕痣与白癜风的相关性及祛除晕痣中央痣对疗效的影响。方法 收集2010-07至2017-10就诊于武警特色医学中心白癜风门诊的晕痣患者的临床资料进行统计学分析。结果 144例晕痣患者平均发病年龄(20.69±12.73)岁,皮损单发118例(81.94%),多发26例(18.06%),好发于躯干部(48.62%)及面颈部(41.44%)。125例合并白癜风,其中非节段型占108例(86.40%),节段型占17例(13.60%),与单纯晕痣患者相比就诊时病程较长(P=0.014)。随访106例合并白癜风患者的临床转归情况,祛除晕痣中央痣的疗效明显好于非手术治疗组(P=0.001),而采取CO2激光或者手术祛除晕痣中央痣两种方式之间差异无统计学意义(P=0.694)。17例单纯晕痣患者祛除晕痣中央痣组总体有效率为91.67%,明显好于非手术治疗组。结论 晕痣好发于青少年,皮损以单发多见,以躯干、面颈部好发。大部分晕痣合并白癜风,且以非节段型为主。祛除晕痣中央痣对于晕痣本身及伴发白癜风均可加快其消退。 相似文献
8.
Sanjeev V. Mulekar Ahmed Al Issa Abdullah Al Eisa 《Journal of cosmetic and laser therapy》2013,15(4):245-248
Background: The treatment of halo nevus is controversial and ranges from observation requiring no therapy to excision biopsy. Objective: To assess the efficacy of excimer laser for the treatment of halo nevus. Methods: Four patients with halo nevus on the face were treated by excimer laser three times a week until they achieved 75% pigmentation or a maximum of 36 treatment sessions. They were assessed visually by comparing photographs taken before and at the end of treatment. Results: Two patients re‐pigmented completely and two showed 80% pigmentation. The number of sessions ranged from seven to 35. The study is limited by the small number of patients. Conclusion: Treatment with the 308‐nm excimer laser may be an effective treatment of halo nevi located on the face. 相似文献
9.
Yan-Chang Lei Ling-Ling Yang Wen Li Pan Luo Pei-Fen Zheng 《World journal of gastroenterology : WJG》2015,21(46):13055-13063
AIM: To determine the therapeutic potential of sphingosine kinase 1(Sphk1) inhibition and its underlying mechanism in a well-characterized mouse model of D-galactosamine(D-Gal N)/lipopolysaccharide(LPS)-induced acute liver failure(ALF).METHODS: Balb/c mice were randomly assigned to different groups,with ALF induced by intraperitoneal injection of D-Ga IN(600 mg/kg) and LPS(10 μg/kg). The Kaplan-Meier method was used for survival analysis. Serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) levels at different time points within one week were determined using a multi-parametric analyzer. Serum high-mobility group box 1(HMGB1),tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6,IL-10,and sphingosine-1-phosphate were detected by enzyme-linked immunosorbent assay. Hepatic morphological changes at 36 h after acute liver injury induction were assessed by hematoxylin and eosin staining. HMGB1 expression in hepatocytes and cytoplasmic translocation were detected by immunohistochemistry. Expression of Sphk1 in liver tissue and peripheral blood mononuclear cells(PBMCs) was analyzed by Western blot.RESULTS: The expression of Sphk1 in liver tissue and PBMCs was upregulated in Gal N/LPS-induced ALF. Upregulated Sphk1 expression in liver tissue was mainly caused by Kupffer cells,the resident macrophages of the liver. The survival rates of mice in the N,Ndimethylsphingosine(DMS,a specific inhibitor of Sph K1) treatment group were significantly higher than that of the control group(P 0.001). DMS treatment significantly decreased the levels of serum ALT and AST at 6,12,and 24 h compared with that of the control group(P 0.01 for all). Serum HMGB1 levels at 6,12,and 24 h,as well as serum TNF-α,IL-6,and IL-1β levels at 12 h,were significantly lower in the DMS treatment group than in the control group(P 0.01 for all). Furthermore,hepatic inflammation,necrosis,and HMGB1 cytoplasm translocation in liver cells were significantly decreased in the DMS treatment group compared to the control group(43.72% ± 5.51% vs 3.57% ± 0.83%,χ2 = 12.81,P 0.01).CONCLUSION: Inhibition of Sph K1 ameliorates ALF by reducing HMGB1 cytoplasmic translocation in liver cells,and so might be a potential therapeutic strategy for this disease. 相似文献
10.
J.I. Stewart G.E. D'Alonzo D.E. Ciccolella N.B. Patel H. Durra H.E. Clauss 《Transplant infectious disease》2014,16(1):115-118
Without proper treatment, the mortality of pulmonary mucormycosis is nearly 100%. Although the diagnosis is often made histologically, it can be suspected when patients have a reverse halo sign on computed tomography (CT) of the chest, along with the right clinical findings. We describe the case of a woman 7 months post renal transplant who presented with fevers, malaise, and chest pain. Her chest CT revealed a round, focal area of ground‐glass attenuation surrounded by a complete rim of consolidation in the left upper lobe, consistent with the reverse halo sign. Pulmonary mucormycosis was diagnosed by transbronchial lung biopsy. She was successfully treated with combined medical and surgical therapies. In the context of this case, we provide a brief review of the diagnosis of pulmonary mucormycosis, with a focus on radiographic and pathologic findings. 相似文献