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《Clinical lung cancer》2022,23(1):e29-e42
Background: We sought to evaluate prognostic value of neutrophil-to-lymphocyte ratio (NLR) in surgically resected non-small cell lung cancer (NSCLC) and its correlation to oncogenic drivers.We retrospectively reviewed data of patients who underwent anatomic lung resection for NSCLC and whose mutational status was known, from 4 department of thoracic surgery, over the period 2008 to 2019. Primary endpoints were overall survival (OS) and time to recurrence (TTR). Clinical and molecular factors were investigated in the univariate and multivariate analysis for their association with the primary endpoints.Results: 2027 patients were included in the analysis. Correlations between NLR and OS (R2=0.21), NLR and TTR (R2=0.085) were significant (P<0.0001), with corresponding Pearson R of -0.46 (P<0.0001) and -0.292 (P<0.001), respectively. ROC curve analysis defined NLR cut-off value at 4.07.In the univariable analysis, the median OS was 66 months (95% CI: 62.94 – 69.06) in case of pre-operative NLR ≤ 4.07 and 38 months (95% CI: 36.73 – 39.27) in case of pre-operative NLR > 4.07 (P<0.0001), with corresponding 5-y OS of 72% and 29% respectively. Median TTR was associated with pre-operative NLR. Median TTR was 25 months (95% CI: 21.52 – 28.48) in case of pre-operative NLR ≤ 4.07 and 17 months (95% CI: 16.04 – 17.96) in case of pre-operative NLR > 4.07 (P<0.0001), with corresponding 5-years TTR of 18% and 9% respectively. Significant correlations between NLR >4.07 and KRAS (Cramer's V = 0.082, P < 0.0001) and EGFR mutations (Cramer's V = 0.064, P = 0.004) were observed.Conclusions: Low pre-operative NLR is associated with longer OS in patients with resected NSCLC. Low pre-operative NLR is not associated with longer TTR in multivariate analysis. Correlation between the high NLR and KRAS/EGFR mutations were observed.  相似文献   
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Background: Chromium (Cr) is a transition metal, natural element. Chromium is the 21st most abundant element in Earth’s crust. Cr is found in soil, rocks and living organisms. It may have various oxidation states, from -2 to +6, but most of these states are too unstable to exist in any significant quantities. The purpose of this review and meta-analysis is to critically assess the scientific evidence on the carcinogenic effects of chromium (Cr) and to determine whether there is currently sufficient evidence to suggest that that there is a link between chromium levels in hair and blood serum and breast cancer in women. Material and methods: Research on the relationship between heavy metal chromium and the risk of developing breast cancer has been searched in PubMed, EMBASE, Web of Science, Scopus among papers published between January 2000 and September 2020. The search used the following terms (MeSH): breast cancer, women, trace elements, metals, chromium, chemically-induced, hair, serum using additional terms. Results: In the second group of comparisons of women from “ecologically clean” districts of Aktobe Region, there were significantly lower indicators of the microelements in tumor tissue. The amount of Fe ranges from 38.46 to 65.39 ug/g (average 49.56±5.81 ug/g), Cu from 2.8 to 6.69 ug/g (average 5.06±1.01 ug/g), Zn from 1.89 to 5.38 ug/g (average 3.88±0.89 ug/g), Cr from zero to 6,1 ug/g (average 2.13±1.29 ug/g), Ni from 0.11 to 0.42 ug/g (average 0.28±0.067 ug/g) и Pb from zero to 0.19 ug/g (average 0.098±0.06 ug/g). Conclusion: The article established that women who live or work in ecologically polluted areas or have problems with micronutrient exchange need in-depth screening and more frequent screening for early detection of pre- and breast cancer.  相似文献   
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目的 探究低剂量电离辐射对医疗机构放射工作人员外周静脉血清中胰岛素样生长因子结合蛋白3(IGFBP-3)表达水平的影响。方法 采用单纯随机抽样法选取183名放射工作人员纳入此次研究,按放射工种分组,其中介入放射学组37例、核医学组43例、放射治疗组48例和诊断放射学组55例。血清IGFBP-3浓度测定采用酶联免疫吸附试验。结果 4个不同工种组间放射工作人员血清IGFBP-3浓度的差异具有统计学意义(F=6.056,P<0.05),其中介入放射学组血清IGFBP-3浓度最高(t=2.815、3.611、3.936,P<0.05);不同年有效剂量组间放射工作人员血清中IGFBP-3的浓度差异具有统计学意义(F=8.380,P<0.05)。随着放射工龄和年有效剂量的增加,放射工作人员血清IGFBP-3浓度呈现上升趋势(rs=0.202、0.151,P<0.05)。结论 血清IGFBP-3表达水平有作为反映长期慢性低剂量电离辐射累积暴露的生物标志物的潜力。  相似文献   
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