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排序方式: 共有268条查询结果,搜索用时 31 毫秒
1.
血脂水平在长时期内的生物学变异   总被引:44,自引:2,他引:42  
目的:探讨我国人血脂水平的长期个体内生物学变异情况。方法:在多年从事血脂标准化研究及参加国际血脂标准化计划基础上长期测定一相对稳定人群的血脂水平,分析其中23例1年多次及100例10-15年间每年1次血脂测定结果。结果:两组病例血脂水平的个体内总变异(包括生物学变异和分析变异)大致为,总胆固醇10%,甘油三酯28%,低密度脂蛋白胆固醇18%,高密度脂蛋白胆固醇16%。结论:血脂指标,尤其是甘油三酯有较大生物学变异,临床上判断血脂水平高低时需考虑到生物学变异的存在,并采取适当措施减小生物学变异。  相似文献
2.
AIMS: Insulin is a potent stimulator of adipose tissue lipoprotein lipase (LPL). Logically, the postprandial period is therefore a privileged time of the day for the regulation of LPL by insulin in this tissue. It is not clear to what extent a defect such as insulin resistance could affect this regulation and contribute to postprandial, as well as fasting, hypertriglyceridaemia. The aim of the present protocol was to study the relationship between insulin resistance and LPL in adipose tissue and in plasma, in the particular context of the postprandial period. METHODS: For this study, 26 adult nondiabetic individuals (12 women and 14 men) with a wide range of whole-body insulin-mediated glucose uptake (as assessed with an insulin suppression test) were studied. An abdominal subcutaneous fat biopsy on one occasion, and post-heparin plasma on another occasion, were obtained 4 h into a standardized meal profile administered in the fasting state. RESULTS: Postprandial triglyceride excursions (evaluated by the incremental area under the curve during the metabolic meal profile) were inversely correlated to adipose tissue LPL mRNA levels (rho = -0.43, P < 0.03) as well as to adipose tissue LPL heparin-releasable activity (rho = -0.58, P < 0.01). Steady-state plasma glucose (SSPG) concentrations during the insulin suppression test, a reflection of the degree of insulin resistance, were also negatively correlated to adipose tissue LPL mRNA (rho = -0.50, P < 0.02) and activity (rho = -0.56, P < 0.01). There was no correlation between plasma post-heparin LPL activity/mass and postprandial triglycerides nor with insulin resistance. CONCLUSION: Regulation of adipose tissue LPL is significantly affected in insulin-resistant individuals in the postprandial period. This presumed impaired effect of insulin on LPL postprandially could be an important contributor to the atherogenic dyslipidaemia described in insulin resistance syndrome.  相似文献
3.
Abstract. Very low density lipoprotein kinetic parameters were compared in familial hypertriglyceridaemia and familial combined hyperlipidaemia, two distinct genetic forms of hypertriglyceridaemia. Very low density lipoprotein apoprotein B turnover rate was greater in hypertriglyceridaemic subjects with familial combined hyperlipidaemia (099±0–27 mg/kg/h; n = 5; P < 0005) and also in familial hypertriglyceridaemia (0–74±0–10; n = 6; P < 0–005) than in age and weight matched non-hyperlipidaemic controls (0–54±0–21; n = 6), suggesting that the hypertriglyceridaemia seen in both genetic disorders was due to very low density lipoprotein overproduction. Very low density lipoprotein apoprotein B turnover rate was greater in familial combined hyperlipidaemia than in familial hypertriglyceridaemia while plasma triglyceride turnover was higher in familial hypertriglyceridaemia. This disparity in the turnover rates of apoprotein B and triglyceride between these disorders was accompanied by a higher very low density lipoprotein triglyceride/apoprotein B ratio in familial hypertriglyceridaemia than in familial combined hyperlipidaemia ( P < 0001) and in normals ( P < 0–005).
The findings suggest that the hypertriglyceridaemia of familial combined hyperlipidaemia is due to overproduction of very low density lipoprotein of normal composition, while that of familial hypertriglyceridaemia is due to oversecretion of triglyceride-enriched very low density lipoprotein.  相似文献
4.
健康人脂肪耐量试验460例分析   总被引:13,自引:0,他引:13  
目的:探讨体力劳动者和脑力劳动者青、中、老年组、男、女性别间餐后脂肪清除规律,建立适合中国人群的脂肪耐量试验方法。方法:选择460名志愿者服脂肪负荷餐,测定空腹及脂肪餐后血浆乳糜浊度(A)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)水平,绘制脂质应答曲线和清除时限图。结果:餐后TG随血浆A水平升高和降低,两者呈正相关,体力劳动者组青年妇性,青、中年男性TG在餐后3h达高峰,峰值1.30,2.08,2.42mmol/L.中、老年女性和老年男性TG在餐后5h达高峰,峰值为2.87,293,3.33mmol/L。脑血劳动者中年男、女性、老年男、女性TG峰匀在餐后5小时,升高水平分别为3.15,2.82,4.68,4.57mmol/L,各组餐后8hTG基本恢复至空腹水平。血浆HDL-C与A和TG水平呈负相关,餐后高TG应答导致HDL-C降低。结论:不同劳动强度、年龄和性别间脂肪耐量不同,尤其是脑力劳动者、老年组和女性组对脂肪耐受量较差。脂肪耐量试验基本项目应包括A、TG和HDL-C三项,标本采集时间在空腹和餐后8h有实际意义。  相似文献
5.
2型糖尿病患者血脂、血糖与血流变检测指标比较   总被引:13,自引:1,他引:12  
目的探讨2型糖尿病患者血脂(TC、TG)水平与血液流变学指标对糖尿病的影响.方法检测80例2型糖尿病患者TG、TC、纤维蛋白原(FIB)以及血液流变学指标,并与对照组对比分析.结果 2型糖尿病组TC、TG、TGB、FIB、ηb、ηp、TK、HCT、ESR等指标均明显高于对照组.结论 2型糖尿病患者存在明显的血脂及血液流变学指标的异常,这些危险因素可能是导致糖尿病慢性并发症特别是血管并发症发生、加重的原因之一.临床治疗上应重视降脂、抗凝、扩容和降低血液粘度改善微循环的治疗.  相似文献
6.
小檗碱治疗2型糖尿病40例疗效观察   总被引:8,自引:0,他引:8  
目的探讨小檗碱在治疗2型糖尿病中的临床疗效。方法2型糖尿病患者共40例,男24例,女16例。年龄36~62岁。病程2~14年。所有患者均执行糖尿病饮食及运动治疗,在口服小檗碱的同时,原用药种类及剂量不变。观察治疗前后血脂、血糖(空腹及餐后2 h)、胰岛素(空腹及餐后2 h)的变化。结果治疗后空腹血糖及餐后2 h血糖明显下降,差异有显著性(P<0.05),空腹及餐后2 h胰岛素明显升高(P<0.05),差异显著,胆固醇及甘油三酯的降低亦有显著性差异(P<0.05)。结论小檗碱能明显降低2型糖尿病患者的血糖、血脂,并能改善胰岛素分泌。  相似文献
7.
Abstract. Free fatty acid and triglyceride metabolism was studied in diet-responsive and insulin-dependent diabetics and in non-diabetic obese patients before and during treatment. Free fatty acid turnover was elevated in diabetics and in most obese patients, and was decreased by diabetic control; it showed no significant change in the obese patients during caloric restriction. Plasma triglyceride levels exceeded 160 mg/100 ml in 20 of the 34 diabetics, and gross lipaemia occurred both in insulin-requiring and diet-responsive patients. The fractional turnover of injected triglyceride was low in 20 of 33 measurements on untreated diabetics, and was negatively correlated with endogenous triglyceride levels. The fractional turnover increased significantly during diabetic control. These findings are compatible with the view that diabetic hypertrigly ceridaemia may be due in part to impaired removal of triglyceride from plasma.  相似文献
8.
磁处理酒对小鼠血脂及血糖的影响   总被引:7,自引:1,他引:6  
目的 观察磁处理酒对小鼠血脂及血糖的影响。方法  3组小鼠分别饮用含乙醇 10 %磁处理白酒 (磁处理白酒组 )、10 %未经磁处理白酒 (白酒组 )、自来水 (对照组 ) 38d后 ,取血清用酶法测定血脂及血糖。结果 对血清中高密度脂蛋白 -胆固醇 (HDL -Ch)含量 ,磁处理白酒组 ( 2 .42 0±0 .6 2 7)mmol/L ,比对照组 ( 2 .0 77± 0 .5 0 5 )mmol/L显著升高 (P <0 .0 5 ) ,白酒组 ( 1.980±0 .5 48)mmol/L ,与对照组差异无显著性 (P >0 .0 5 ) ;对总胆固醇含量 ,二者均无明显影响 (P >0 .0 5 ) ;对甘油三酯含量 ,磁处理组白酒有降低作用 ( 1.0 86± 0 .336 )mmol/L ,白酒有升高作用 ( 1.36 5±0 .6 6 0 )mmol/L ,二者与对照组 ( 1.2 0 1± 0 .491)mmol/L相比 ,差异虽均无显著性 (P >0 .0 5 ) ,但磁处理白酒组与白酒组之间差异有显著性 (P <0 .0 5 ) ;对血糖含量 ,磁处理白酒有显著降低作用 (P <0 .0 1) ,白酒虽亦有降低作用 ,但差异无显著性 (P >0 .0 5 )。结论 磁处理白酒对血脂的影响优于一般白酒  相似文献
9.
Abstract. In order to gain further insight into the relationship between high-density lipoprotein (HDL) metabolism and plasma triglyceride transport, measurements were made of HDL cholesterol concentration, apoprotein (apo) AI and AII metabolism, very-low-density lipoprotein (VLDL) apo B metabolism, and heparin-elutable adipose tissue lipoprotein lipase (LPL) activity in seventeen subjects with a wide range of plasma triglyceride concentrations (0.8–25 mmol/l).
The fractional catabolic rate (FCR) of VLDL apo B was directly related to LPL activity ( r =+ 0.80), providing evidence that the activity of the enzyme in adipose tissue is a determinant of the rate of lipolysis of VLDL in man. HDL cholesterol concentration was a positive function of both VLDL apo B FCR ( r =+ 0.74) and LPL activity, a finding consistent with previous evidence for the origin of a proportion of HDL cholesterol from 'surface remnants' liberated during VLDL catabolism. The FCRs of both apo AI and apo AII were inversely related to VLDL apo B FCR (AI, r = - 0.52; AII, r = - 0.69) and to LPL activity. The synthetic rate of apo AII, but not that of apo AI, was positively correlated with VLDL apo B synthesis ( r =+ 0.71). Thus, the metabolism of the major proteins of HDL in man appears to be closely associated with VLDL metabolism.  相似文献
10.
Plasma lipids in HIV-infected patients: a prospective study in 95 patients   总被引:6,自引:0,他引:6  
Abstract. The present study aimed to determine plasma lipid levels in 95 HIV-infected patients divided into four groups according to the CD4 lymphocyte counts comparatively to a control group of 20 HIV-negative normolipidaemic subjects. A relationship between lipidic abnormalities and immune or nutritional status was also investigated. The patients below 200 CD4 lymphocyte mm-3 (groups 1 and 2) had significantly lower total cholesterol than the controls. The patients below 400 CD4 lymphocytes mm-3 (groups 1, 2, 3) had significantly higher triglycerides and Lp(a) but lower LDL-cholesterol than the controls. In all HIV-positive patients, whatever their CD4 lymphocyte count, HDL-C and apoA1 were lower than in the controls. By multivariate analysis triglycerides were positively correlated to acute opportunistic infections and to interferon- α levels, while cholesterol was negatively correlated to TNF- α , and LDL-C was positively correlated to albuminaemia. The latter parameter was the only lipidic value to correlate with nutritional markers. The contamination route, or the presence of wasting, was not correlated to any lipidic disorder.  相似文献
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