全文获取类型
收费全文 | 34370篇 |
免费 | 2448篇 |
国内免费 | 2072篇 |
专业分类
耳鼻咽喉 | 1498篇 |
儿科学 | 240篇 |
妇产科学 | 114篇 |
基础医学 | 4951篇 |
口腔科学 | 922篇 |
临床医学 | 2917篇 |
内科学 | 1760篇 |
皮肤病学 | 182篇 |
神经病学 | 8728篇 |
特种医学 | 1002篇 |
外国民族医学 | 2篇 |
外科学 | 6159篇 |
综合类 | 4336篇 |
预防医学 | 430篇 |
眼科学 | 2467篇 |
药学 | 1861篇 |
15篇 | |
中国医学 | 874篇 |
肿瘤学 | 432篇 |
出版年
2024年 | 27篇 |
2023年 | 429篇 |
2022年 | 612篇 |
2021年 | 1031篇 |
2020年 | 1156篇 |
2019年 | 1018篇 |
2018年 | 969篇 |
2017年 | 1266篇 |
2016年 | 1257篇 |
2015年 | 1227篇 |
2014年 | 2019篇 |
2013年 | 2066篇 |
2012年 | 1569篇 |
2011年 | 1754篇 |
2010年 | 1634篇 |
2009年 | 1450篇 |
2008年 | 1660篇 |
2007年 | 1653篇 |
2006年 | 1533篇 |
2005年 | 1301篇 |
2004年 | 1227篇 |
2003年 | 1156篇 |
2002年 | 1019篇 |
2001年 | 921篇 |
2000年 | 760篇 |
1999年 | 713篇 |
1998年 | 625篇 |
1997年 | 584篇 |
1996年 | 464篇 |
1995年 | 538篇 |
1994年 | 454篇 |
1993年 | 414篇 |
1992年 | 435篇 |
1991年 | 379篇 |
1990年 | 373篇 |
1989年 | 315篇 |
1988年 | 274篇 |
1987年 | 278篇 |
1986年 | 278篇 |
1985年 | 374篇 |
1984年 | 313篇 |
1983年 | 232篇 |
1982年 | 254篇 |
1981年 | 231篇 |
1980年 | 198篇 |
1979年 | 128篇 |
1978年 | 85篇 |
1977年 | 75篇 |
1976年 | 58篇 |
1975年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
2.
3.
4.
Ludefu Su Yu Liu Yanhong Tang Mingmin Zhou Liang Xiong Congxin Huang 《International journal of clinical and experimental pathology》2021,14(4):408
Background and objective: Myocardial infarction (MI) is a common critical disease of the cardiovascular system. The process of MI is often accompanied by the excessive activation of cardiac sympathetic nerves, which leads to arrhythmia. Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. However, whether RTX can reduce the occurrence of arrhythmia and exert a cardioprotective effect by inhibiting the sympathetic reflex during MI is still unknown. Methods: The left anterior descending artery of cardiac was clamped to construct a model of MI. RTX (50 μg/ml) was used by epicardial application in MI rats. Ventricular electrophysiologic properties were continuously monitored by a body surface ECG. Yrosine hydroxylase (TH) and growth associated protein 43 (GAP43) were detected by Immunofluorescence staining. Connexin43 and transforming growth factor beta receptor 1 (TGF-β1) were detected by western blot. Norepinephrine (NE) and BNP levels in blood and tissue were determined by ELISA. Cardiac function was assessed by echocardiography. Results: The ERP, APD90, QRS, QT and the Tend-Tpeak intervals in MI rats were all prolonged, but decreased after RTX treatment (n = 3, P<0.05). In contrast, the RR interval was shortened in the MI group, but prolonged in the MI+RTX group (n = 3, P<0.05). RTX treatment significantly reduced ventricular arrhythmias after MI. TH- and GAP43-positive nerve densities and TGF-β1, and cx-43 protein expression were up-regulated in the MI group compared to the sham group, and they were decreased in the MI+RTX group compared to the MI group (n = 3, P<0.05). RTX can decrease serum and tissue NE and BNP levels (n = 3, P<0.05). RTX pretreatment significantly decreased heart rate, HW/BW ratio and LVIDS, and increased LVEF andLVFS values (n = 3, P<0.05). Conclusion: RTX improved cardiac dysfunction, ventricular electrophysiologic properties, and sympathetic nerve remodeling in rats with MI by inhibiting the excessive cardiac sympathetic drive. 相似文献
5.
6.
Soraia Azevedo Francisca Guimarães Joana Ramos Rodrigues Ricardo Branco Elisa Rodrigues Filipa Teixeira 《Reumatología clinica》2021,17(7):422-424
IntroductionNerve compression by anomalous masses located at the wrist and distal forearm is an infrequent condition. They may compress underlying structures in the carpal tunnel region, causing pain and paresthesias, which leads to the wrong diagnosis of carpal tunnel syndrome.Clinical casesWe present three cases of patients with symptomatology and clinical tests compatible with compression of the median nerve in the carpal tunnel but whose physical examination showed a soft mass in the distal region of the forearm which was compressing the median nerve, as demonstrated by ultrasound evaluation.DiscussionThe reported cases of accessory muscles or lipomas described in the literature as causes of median nerve compression clinic are mainly described only after the surgical decompression of the carpal tunnel, due to the maintenance of residual symptoms.ConclusionCareful examination with an ultrasound evaluation prior to surgery may help to identify these cases and help planning surgical treatment. 相似文献
7.
目的:基于原发肿瘤及淋巴结CT特征建立评分模型预测食管鳞癌患者喉返神经旁淋巴结(RLN-LN)转移风险。方法:回顾性收集2014年1月至2019年12月于北京大学肿瘤医院行食管癌根治术并清扫RLN-LN的92例食管鳞癌患者。根据术后淋巴结病理结果分为RLN-LN转移组(n=37)和非转移组(n=55)。评估术前CT图像,记录食管癌患者年龄、性别、分化程度、肿瘤位置、肿瘤大小(肿瘤长度、肿瘤厚度、厚度/长度)、RLN-LN大小(淋巴结短径、长径、短径/多平面重建(MPR)最长径]。采用多元logistic回归筛选独立预测因子并建立评分模型,采用ROC曲线评估评分模型及独立预测因子诊断RLN-LN转移的效能,采用Z检验比较曲线下面积(AUC)的差异。应用Hosmer-Lemeshow检验和校准曲线评估模型拟合度。结果:肿瘤位置、肿瘤长度、RLN-LN短径、短径/MPR最长径是RLN-LN转移的独立预测因子,其诊断RLN-LN转移的AUC分别为0.586、0.705、0.831、0.777。基于以上4个CT特征建立评分模型,评分模型诊断RLN-LN转移的AUC为0.903(95%CI 0.846~0.959),优于各单一CT特征(Z=5.812,P<0.001;Z=2.161,P=0.030;Z=2.929,P=0.003;Z=4.052,P<0.001)。拟合优度Hosmer-Lemeshow检验结果显示P=0.555,校准曲线提示评分模型预测RLN-LN转移风险与实际转移风险之间具有良好的一致性。结论:基于CT图像的评分模型有助于食管鳞癌RLN-LN转移状态危险分层。 相似文献
8.
9.
10.