首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   15626篇
  免费   1975篇
  国内免费   704篇
耳鼻咽喉   41篇
儿科学   151篇
妇产科学   70篇
基础医学   1543篇
口腔科学   167篇
临床医学   1139篇
内科学   1758篇
皮肤病学   128篇
神经病学   1869篇
特种医学   335篇
外科学   841篇
综合类   3058篇
现状与发展   4篇
预防医学   1619篇
眼科学   171篇
药学   2341篇
  19篇
中国医学   2470篇
肿瘤学   581篇
  2024年   220篇
  2023年   704篇
  2022年   1363篇
  2021年   1578篇
  2020年   1237篇
  2019年   795篇
  2018年   581篇
  2017年   569篇
  2016年   512篇
  2015年   592篇
  2014年   856篇
  2013年   946篇
  2012年   790篇
  2011年   803篇
  2010年   690篇
  2009年   552篇
  2008年   681篇
  2007年   681篇
  2006年   597篇
  2005年   548篇
  2004年   416篇
  2003年   513篇
  2002年   283篇
  2001年   280篇
  2000年   209篇
  1999年   174篇
  1998年   157篇
  1997年   163篇
  1996年   109篇
  1995年   131篇
  1994年   102篇
  1993年   67篇
  1992年   55篇
  1991年   58篇
  1990年   39篇
  1989年   42篇
  1988年   27篇
  1987年   19篇
  1986年   30篇
  1985年   20篇
  1984年   16篇
  1983年   10篇
  1982年   16篇
  1981年   12篇
  1980年   9篇
  1979年   6篇
  1978年   12篇
  1977年   9篇
  1976年   9篇
  1971年   5篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
The specialty of emergency medicine in Australasia is coming of age. As part of this maturation there is a need for high‐quality evidence to inform practice. This article describes the development of the New Zealand Emergency Medicine Network, a collaboration of committed emergency care researchers who share the vision that New Zealand/Aotearoa will have a world‐leading, patient‐centred emergency care research network, which will improve emergency care for all, so that people coming to any ED in the country will have access to the same world‐class emergency care.  相似文献   
2.
3.
1. To investigate Genkwa Flos hepatotoxicity, a cell metabolomics strategy combined with serum pharmacology was performed on human HL-7702 liver cells in this study.

2. Firstly, cell viability and biochemical indicators were determined and the cell morphology was observed to confirm the cell injury and develop a cell hepatotoxicity model. Then, with the help of cell metabolomics based on UPLC-MS, the Genkwa Flos group samples were completely separated from the blank group samples in the score plots and seven upregulated as well as two down-regulated putative biomarkers in the loading plot were identified and confirmed. Besides, two signal molecules and four enzymes involved in biosynthesis pathway of lysophosphatidylcholine and the sphingosine kinase/sphingosine-1-phosphate pathway were determined to investigate the relationship between Genkwa Flos hepatotoxicity and these two classic pathways. Finally, the metabolic pathways related to specific biomarkers and two classic metabolic pathways were analyzed to explain the possible mechanism of Genkwa Flos hepatotoxicity.

3. Based on the results, lipid peroxidation and oxidative stress, phospholipase A2/lysophosphatidylcholine pathway, the disturbance of sphingosine-1-phosphate metabolic profile centered on sphingosine kinase/sphingosine-1-phosphate pathway and fatty acid metabolism might be critical participators in the progression of liver injury induced by Genkwa Flos.  相似文献   

4.
5.
随着生物医用材料研制和医学的迅速发展,以及生活水平、医疗保健、康复水平的提高,人们对自身组织、器官及骨骼缺损的修复和置换方面的要求日益提高,尤其对人造骨骼和人工关节的需求越来越广泛。由于计算机断层成像技术CT(computed tomography)已经成为显示和研究人体内部结构非常有用的手段,将计算机辅助设计技术CAD(Computer aided design)和计算机辅助工程CAE(Computer aided Engineering)等相关技术应用于人造骨骼和内置假体的设计,不仅可以提高产品的设计质量,同时,结合CT和计算机三维重建方法,  相似文献   
6.
Summary During pacemaker implantation in a patient with permanent atrial fibrillation, it remained impossible to advance a passive fixation lead with fins through the right atrium. However, a lead with a retractable screw easily passed the right atrium and was positioned in the right ventricle. Transesophageal echocardiography revealed an extensive net–like perforated Eustachian valve within the right atrium that had caused entrapment of the anchor fins during lead implantation. Remnants of embryonal structures within the right atrium should be considered a rare possible barrier during pacemaker implantation.  相似文献   
7.
无线网络技术在医学仪器中的应用   总被引:1,自引:0,他引:1  
简要介绍无线网络技术的原理、特点及其在医学仪器中的应用.  相似文献   
8.
李翔  唐慧 《医疗卫生装备》2010,31(4):37-37,39
目的:由于办公需要,将以前走电信出口的图书馆、医疗二系及研究生处的用户改道为走科研教育网出口,和华中科技大学校总部相连,并在不改变原来管理模式下同时管理两出口的用户信息。方法:通过配置流分类,规定重定向行为以及配置策略路由进行实现。结果:将认证流和数据流分开,成功实现了医院内部两出口的需求。结论:利用原有设备的流分类和重定向功能.既可解决两出口的内部需求,也能在不增加设备的情况下对用户信息进行管理,为医院节省了开支。  相似文献   
9.
The Department of Health has funded a national diabetes network to support clinical research. The network will facilitate recruitment into clinical trials and has been widely welcomed by clinicians. However, if the network is to reach its full potential, all those involved will need to advocate a change in attitude towards clinical trials and research, encouraging participation and contribution of data. Clinicians need to be willing to take a proactive view about research studies, and to encourage patients to adopt a positive and altruistic attitude towards trial participation. The future of trials and other important clinical research in the UK may depend on it.  相似文献   
10.
Background The skin microdiallysis technique makes it possible to measure histamine release in intact human skin in vivo directly. In this study we have used the microdialysis technique to characterize histamine release by codeine after intracutaneous injectioin and following skin challenge by a novel atraumatic delivery technique. Objective The purpose of the study was to compare histamine release in human skin by codeine. delivered by an intraprobe drug delivery system (IPD) and intracutaneous injections (ICT), with respect to dose-response relations, kinetics of histamine appearance and decay, corelations between histamine release and skin respones, and reproducibility. Methods Hollow dialysis fibres were inserted intradermally in 12 healthy subjects. Twelve fibres were inserted in each subjects, six fibres in each arm. Each fibre was perfused at a rate of 3 μL/min, and samples were collected in 2 min fractions. By the IPD technique, codeine was administrered to the skin by adding codeine to the perfusion medium. Sequential IPD challenges were performed in one arm. and ICTs were done on the other arm. Results Sixfold serial dilutions of codeine (0.01-3 mg/mL) caused a significant doserelated histamine release by ICT and IPD. Peak histamine release was found within the first 4 min after skin challenge by ICT and IPD, followed by a fast decline with a dialysate histamine half life of approximately 2-3 min. Peak hisamine release was linearly correlates with cumulative release of the 20 min sampling period, and histamine release correlated with weal soze. The coefficient of variation on peak histamine releae was 18.9% and 4.8% for codeine ICT and IPD, respectively. Conclusioin We have described in detail codeine-induced histamine release in intact human skin in vivo by the microdialysis technique. It was possible to administer codeine atraumaticallyl to the skin by intraprobe delivery. The skin microdialysis codeine atraumaticallly to the skin by intraprobe delivery. The skin microdialysis technique opens up possibilities for measurement of infllammatory mediators release in normal and diseases skin, and it will be possible to deliver immunopharmacologically active drugsto the skin by intraprobe delivery.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号