全文获取类型
收费全文 | 398篇 |
免费 | 21篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 44篇 |
妇产科学 | 1篇 |
基础医学 | 82篇 |
临床医学 | 20篇 |
内科学 | 2篇 |
皮肤病学 | 1篇 |
神经病学 | 81篇 |
特种医学 | 12篇 |
外科学 | 40篇 |
综合类 | 12篇 |
预防医学 | 2篇 |
药学 | 1篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 14篇 |
2020年 | 15篇 |
2019年 | 15篇 |
2018年 | 9篇 |
2017年 | 6篇 |
2016年 | 16篇 |
2015年 | 15篇 |
2014年 | 18篇 |
2013年 | 23篇 |
2012年 | 23篇 |
2011年 | 16篇 |
2010年 | 23篇 |
2009年 | 19篇 |
2008年 | 19篇 |
2007年 | 14篇 |
2006年 | 20篇 |
2005年 | 12篇 |
2004年 | 15篇 |
2003年 | 10篇 |
2002年 | 10篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 12篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1996年 | 9篇 |
1995年 | 2篇 |
1994年 | 9篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 1篇 |
1988年 | 7篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1977年 | 1篇 |
排序方式: 共有420条查询结果,搜索用时 218 毫秒
1.
2.
室管膜瘤是一种原发于神经上皮的中枢神经系统肿瘤,病变累及脑和脊髓,多发于儿童。基因分型的新分类方法,为室管膜瘤的治疗和预后评估提供了更为可靠的依据。室管膜瘤对辅助治疗的敏感性低是造成患儿预后较差的重要原因之一。该文对近年来儿童室管膜瘤的分型、诊断、治疗策略等进行综述。 相似文献
3.
Classic type intradural extramedullary (IDEM) ependymomas of the lumbar spine are rare entities. Only two such cases have previously been reported in the literature. Here the authors report a new case and describe radiological, surgical and histological findings as well as review the literature. Unlike previously encountered lumbar IDEM ependymomas, this case was an incidental finding and surgically managed on the grounds of radiological progression over 8 years. 相似文献
4.
5.
6.
C11orf95‐RELA fusion present in a primary intracranial extra‐axial ependymoma: Report of a case with literature review 下载免费PDF全文
Aruna Nambirajan Prit Benny Malgulwar Mehar C. Sharma Anutosh Singh Pankaj Pathak Guru Dutta Satyarthee Ajay Garg 《Neuropathology》2016,36(5):490-495
Ependymomas are gliomas that recapitulate the ependymal cells microscopically and ultrastructurally. They commonly occur along the ventricular surfaces and central canal of the brain and spinal cord. Intracranial extra‐axial ependymoma (IEAE) is a rare entity and is commonly misdiagnosed clinically and radiologically as a meningioma. The histogenesis of such IEAEs is obscure. A novel recurrent oncogenic fusion involving the C11orf95 and RELA genes was recently described in supratentorial ependymomas. A 9‐year‐old girl presented with a dural based parafalcine mass that, in addition to exhibiting classical immunohistochemical features of an ependymoma, also demonstrated C11orf95‐RELA fusion, characteristic of supratentorial ependymomas. We suggest that IEAEs share their histogenesis with their intra‐axial counterparts, arising either from dural extension of subcortical, subependymal rests or directly from ectopic dural rests. 相似文献
7.
Osteoradionecrosis is a known complication following radiation therapy, presenting most commonly in the cervical spine as a delayed consequence of radiation that is often necessary in the management of head and neck cancers. In contrast, osteoradionecrosis has rarely been described in the lumbar spine. Here we describe, to our knowledge, the first reported case of lumbar spine osteoradionecrosis, after adjuvant radiation for a primary spinal cord tumor, leading to progressive degenerative scoliosis which required subsequent operative management. Established guidelines recommend that mature bone can tolerate a dose of up to 6000 cGy without injury. However, once bone has been exposed to radiation over this level progressive soft tissue changes may lead to devascularization, leaving the bone vulnerable to osteonecrosis, specifically when manipulated. Radiation necrosis can be progressive and lead to eventual mechanical instability requiring debridement and surgical fixation. In the setting of the lumbar spine, osseous necrosis can lead to biomechanical instability, deformity, pain, and neurologic deficit. 相似文献
8.
Damien C. Weber Yucai Wang Robert Miller Salvador Villà Renata Zaucha Alessia Pica Philip Poortmans Yavuz Anacak Gokhan Ozygit Birgitta Baumert Guy Haller Matthias Preusser Jing Li 《Neuro-oncology》2015,17(4):588-595
Background
Spinal myxopapillary ependymomas (MPEs) are slowly growing ependymal gliomas with preferential manifestation in young adults. The aim of this study was to assess the outcome of patients with MPE treated with surgery, radiotherapy (RT), and/or chemotherapy.Methods
The medical records of 183 MPE patients (male: 59%) treated at the MD Anderson Cancer Center and 11 institutions from the Rare Cancer Network were retrospectively reviewed. Mean patient'' age at diagnosis was 35.5 ± 15.8 years. Ninety-seven (53.0%) patients underwent surgery without RT, and 86 (47.0%) were treated with surgery and/or RT. Median RT dose was 50.4 Gy. Median follow-up was 83.9 months.Results
Fifteen (8.2%) patients died, 7 of unrelated cause. The estimated 10-year overall survival was 92.4% (95% CI: 87.7–97.1). Treatment failure was observed in 58 (31.7%) patients. Local failure, distant spinal relapse, and brain failure were observed in 49 (26.8%), 17 (9.3%), and 11 (6.0%) patients, respectively. The estimated 10-year progression-free survival was 61.2% (95% CI: 52.8–69.6). Age (<36 vs ≥36 y), treatment modality (surgery alone vs surgery and RT), and extent of surgery were prognostic factors for local control and progression-free survival on univariate and multivariate analysis.Conclusions
In this series, treatment failure of MPE occurred in approximately one third of patients. The observed recurrence pattern of primary spinal MPE was mainly local, but a substantial number of patients failed nonlocally. Younger patients and those not treated initially with adjuvant RT or not undergoing gross total resection were significantly more likely to present with tumor recurrence/progression. 相似文献9.
EZH2 expression is a prognostic factor in childhood intracranial ependymoma: A Canadian Pediatric Brain Tumor Consortium study 下载免费PDF全文
Amanda M. Li MD MSc Christopher Dunham MD Uri Tabori MD Anne‐Sophie Carret MD P. Daniel McNeely MD Donna Johnston MD Lucie Lafay‐Cousin MD Beverly Wilson MD David D. Eisenstat MD MA Nada Jabado MD PhD Shayna Zelcer MD Mariana Silva MD Katrin Scheinemann MD MSc Christopher Fryer MD Glenda Hendson MB BCh Abbas Fotovati PhD Cynthia Hawkins MD PhD Stephen Yip MD PhD Sandra E. Dunn PhD Juliette Hukin MBBS 《Cancer》2015,121(9):1499-1507
10.
《Journal of clinical neuroscience》2014,21(11):2017-2019
Superficial siderosis of the central nervous system is a syndrome caused by deposition of hemosiderin in the subpial layers of the central nervous system, occurring as a result of recurrent asymptomatic or symptomatic bleeding into the subarachnoid space. We report a rare case of superficial siderosis in a 33-year-old man who presented with sensorineural hearing loss. The diagnosis of superficial siderosis on MRI brain studies led to further investigations with detection of a spinal ependymoma at L1–L2, compressing the cauda equina. Gross total resection of the tumor arrested the progression of the neurological deterioration. Our report underlies the importance of early diagnosis and surgical management, with imaging examination of the full neuroaxis to identify the source of bleeding, to halt disease progression and improve prognosis. 相似文献