朱氏一指禅推法联合电针治疗膝骨关节炎临床疗效观察

目的:对比朱氏一指禅推法联合电针与单纯电针治疗膝骨关节炎的疗效差异。方法:将100例入组患者随机分为观察组和对照组,观察治疗前、治疗3周后及治疗后3个月随访VAS评分、WOMAC量表评分及测量膝关节活动度(ROM)。结果:两组患者治疗3周后及治疗后3个月随访,VAS和WOMAC量表评分及膝关节活动度均较治疗前明显改善,差异有统计学意义(P<0.01);VAS评分两组间差异无统计学意义(P>0.05),观察组改善WOMAC量表评分及膝关节活动度均优于对照组,差异有统计学意义(P<0.01);观察组总有效率均优于对照组,差异有统计学意义(P<0.05)。结论:朱氏一指禅推法联合电针对膝骨关节炎治疗具有显著作用,尤其在改善关节僵硬、躯体功能障碍及恢复膝关节活动度方面更为明显。     

褪黑素及其受体介导的耳甲电刺激降糖效应机制研究进展及展望＊

2型糖尿病发病率逐年攀升，给社会、家庭和个人都带来巨大负担。大量临床研究表明，耳针对高血糖状态具有明显的改善作用，且具有方便、简捷、利于操作等优势。由于2型糖尿病的发生与褪黑素的低水平密切相关，本文试图从褪黑素及其受体的角度进一步揭示耳甲电针降糖效应机制，为临床治疗糖尿病提供科学依据。     

近5年电针治疗突发性耳聋综述

电针治疗突发性耳聋有一定的临床疗效,临床上采用电针治疗突发性耳聋的方法趋于多样化,这对于今后进一步观察电针治疗突发性耳聋的临床疗效有很大的启发与指导价值。但通过这些报道也发现近年来电针治疗突发性耳聋方面研究的不足。首先,文献质量普遍偏低,具体体现在纳入样本量普遍偏少、随机方案不明或无随机、缺乏诊断、纳入、排除标准、疗效标准杂乱、试验方案表述不具体等方面,说明文献质量仍有待提高,缺乏大样本量的RCT试验。其次,研究大多未提及随访,电针治疗突发性耳聋的长远疗效未明确。此外,突发性耳聋患者可存在双耳发病,但在研究中较少提及患耳数,大都是患者例数,其描述的严谨性与准确性有待加强。在未来设计探讨电针治疗突发性耳聋的实验时,要纳入大量样本,研究设计合理并严谨,只有这样才能具有较高的临床参考价值,以便更好地指导临床治疗。     

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome

Objective: To evaluate the effect of electro-acupuncture (EA) in infertile patients with phlegm dampness polycystic ovary syndrome-insulin resistance (PCOS-IR). Methods: Seventy-six PCOS-IR patients who underwnet in vitro fertilization and embryo transfer (IVF-ET) were equally assigned to two groups according to a random digital table: the EA group and the control group, with 38 cases in each group. Before undergoing IVF, the two groups were treated with EA or pseudo-acupuncture, respectively, for 3 menstrual cycles. The intervention was 25 min twice a week until the day of oocyte collection. The selected acupoints were Zhongwan (RN 12), Tianshu (ST 25), Daheng (SP 15), Daimai (GB 26), Qihai (CV 6), Guanyuan (CV 4), and bilateral points including Xuehai (SP 10), Fenglong (ST 40), Zusanli (ST 36), and Yinlingquan (SP 9). Evaluation of phlegm-dampness syndrome score and IR score were carried out before and after treatment. Additionally, the number of oocytes retrieved, transplantable embryo rate, high-quality embryo rate, clinical pregnancy rate and live birth rate were compared between the two groups. Real-time polymerase chain reaction analysis was used to monitor the mRNA expression of the insulin receptor substrate (IRS-1), phosphatidylinositiol 3-kinase (PI3K) and glucose transport factor 4 (GLUT4) in ovarian granulosa cells. Results: EA treatment reduced the phlegm-dampness syndrome score as well as the IR scores compared with the control group (P<0.05). No significant differences in the number of oocytes retrieved and clinical pregnancy rate between the two groups (P>0.05). Moreover, the transplantable embryo rate [49.0% (284/580) vs. 41.9% (273/652)], high-quality embryo rate [36.6% (104/284) vs. 27.8% (76/273)], and live birth rate [50% (19/38) vs. 26.3% (10/38)] in the EA group were significantly higher than in the control group (P<0.05). Gene expression analyses revealed significantly elevated IRS-1, PI3K and GLUT4 mRNA in ovarian granulosa cells of the EA group compared with the control group (P<0.05). Conclusions: EA may ameliorate the effects of phlegm-dampness syndrome and ovarian IR in PCOS-IR patients. Mechanistically, this effect might be through an upregulation of the IRS-1/PI3K/GLUT4 signaling pathway, which may result in improved oocyte quality and embryonic development potential. (Registration No. ChiCTR1800015453)     

加味承气汤保留灌肠联合电针治疗术后早期炎性肠梗阻

目的探讨-种安全有效的治疗术后早期炎性肠梗阻（EPISBO）的方法.方法：共观察60例EPISBO患者.A组30例,单纯运用西医治疗;B组30例,在西医治疗基础上加用加味承气汤保留灌肠联合电针治疗.结果：A组总有效率86.7%,B组总有效率93.3%,二组患者治疗总有效率差异有统计学意义（P〈 0.05）.A组与B组的平均肠鸣音恢复时间分别为（8.6±2.5）d、（6.5±3.1）d,平均肛门排气时间分别为（9.4±3.5）d、（7.1±3.2）d,B组明显优于A组.B组较A组血WBC、CRP治疗后下降明显, 差异有统计学意义（P〈 0.05）;同时B组较A组血ALB治疗后上升明显（P〈 0.05）.二组血清TNF-α、IL-6治疗后较治疗前下降,差异有统计学意义（P〈 0.05）,且B组较A组下降明显（P〈 0.05）;二组血清IL-10治疗后较治疗前上升,且B组较A组上升明显（P〈 0.05）.结论：加味承气汤联合电针治疗EPISBO可缩短疗程,减少促炎因子的释放,促进抗炎因子的分泌,减轻肠壁水肿,减少血浆蛋白的丢失,促进肠功能的恢复,提高疗效,效果显著.     

低频电针及音乐电针对有氧耐力性运动疲劳的康复疗效评价

目的：评估和比较低频电针与音乐电针对运动性疲劳的康复疗效。方法：以49名健康男大学生为受试者、进行有氧耐力运动至疲劳，运用低频电针或音乐电针刺激足三里穴15min，比较治疗前后心率、下肢肌力、血糖、尿蛋白、血乳酸、视觉简单反心时、主观体力感觉（RPE）等生理、生化及心理指标。结果：两种疗法均有显著降低心率及RPE的作用；低频电针可显著降低血乳酸浓度，并且尿蛋白呈大幅度下降的趋势；音乐电针使RPE有较大程度的下降，但下肢肌力及血糖显著低于治疗前，视觉简单反应时有延长趋势，并显著长于安静状态。结论：低频电针疗法具有促进心血管疲劳及心理疲劳康复、增强。肾脏调节功能及加速乳酸清除等作用；音乐电针疗法具有较好的解除心理疲劳的作用，而对运动性疲劳其他方面的康复疗效均逊于低频电针。     

The existence of propagated sensation along the meridian proved by neuroelectrophysiology

Propagated sensation along the meridian can occur when acupoints are stimulated by acupuncture or electrical impulses. In this study, participants with notable propagated sensation along the me-ridian ...     

穴位注射治疗面肌痉挛临床研究

穴位注射法在中医基础理论的指导下将整体辨证施治与现代医学的局部观互补,将针刺的理化作用与药物的药理作用完美统一,副作用小,痛苦少,方便效验,易于被患者接受,是一种很有潜力的治疗方法.穴位注射治疗面肌痉挛的方法有:单用穴位注射疗法或穴位注射配合针刺、电针、内服药物等疗法.     

电针阳明经穴位对偏瘫患者运动功能康复的影响

目的探讨电针阳明经穴位对偏瘫患者运动功能康复的影响。方法54例早期脑卒中后偏瘫患者,分为A、B、C三组,A组行运动疗法,B组行运动疗法加电针阳明经穴,C组行运动疗法加平衡肌张力针法,2周和4周后,根据Ashworth痉挛评级和Fugl-Meyer评定(FMA)评定两组疗效。结果3组治疗后运动功能明显改善、肌张力提高,但B、C组评分高于A组(P<0.05)。治疗4周后B组较C组、A组下肢Ashworth分级评分均有显著性差异(P<0.05)。结论电针偏瘫患者阳明经穴位主要提高患者肌张力,对软瘫期运动功能康复可能有效,而不适用于痉挛期。     

电针对神经病理性疼痛伴发焦虑大鼠行为学及缰核HCN1表达的影响

[目的]观察电针(electro-acupuncture, EA)对神经病理性疼痛伴发焦虑大鼠行为学的干预作用,以及对缰核中超极化激活环核苷酸门控通道蛋白1(hyperpolarization-activated cyclicnucleotide-gated channels 1,HCN1)和c-fos表达的影响,部分阐明神经病理性疼痛伴发精神障碍的发病机制及EA的干预机制。[方法] 32只雄性SD大鼠按完全随机法分为空白对照组、假手术组、坐骨神经分支选择性损伤(sciatic nerve branch selective injury,SNI)组和EA组,每组8只。SNI组和EA组以SNI法制备神经病理性疼痛模型,模型制备第8天起,EA组选取"足三里""昆仑"两穴,以EA治疗,每次30min,1次/d,共3次,其余组别不予治疗。造模前,造模后l、3、5、7、8、9和10d检测机械性缩足反射,造模后第10天采用旷场实验观察大鼠的焦虑情绪,免疫荧光检测缰核HCN1与c-fos的表达。[结果]造模第1天起,与空白对照组比较,假手术组大鼠患侧机械性痛阈各时点差异无统计学意义(P0.05),SNI组大鼠较假手术组下降(P0.01);与SNI组比较,EA组大鼠各时点机械性痛阈均上升(P0.01);4组大鼠健侧机械性痛阈无明显变化(P0.05)。旷场实验中,SNI组大鼠运动总距离、进入中央区次数、中央区运动距离均低于假手术组(P0.01,P0.01,P0.05),而中央区停留时间仅低于空白对照组(P0.05),EA组大鼠运动总距离、进入中央区次数和中央区停留时间均少于SNI组(P0.05,P0.01,P0.01),中央区运动距离差异无统计学意义(P0.05)。各组大鼠健侧内侧缰核(medial habenular nucleus,MHb)、外侧缰核外侧部分(lateral habenular nucleus lateral part,LHb L)和外侧缰核内侧部分(lateral habenular nucleus medial part,LHbM)的HCN1表达差异无统计学意义(P0.05);与假手术组比较,SNI组患侧各部分HCN1表达水平均增高(P0.01,P0.01,P0.01);与SNI组比较,EA组患侧HCN1表达水平均降低(P0.01,P0.01,P0.01)。各组大鼠健侧MHb与LHb L的c-fos表达差异无统计学意义(P0.05);与假手术组比较,SNI组健侧LHbM以及患侧MHb、LHbL的c-fos表达也显著增高(P0.01,P0.05,P0.01),而两组患侧LHbM的c-fos表达差异无统计学意义(P0.05);EA组双侧c-fos的表达均低于SNI组同侧(P0.01,P0.01)。[结论]大鼠患侧缰核HCN1通道可能参与了神经病理性疼痛伴发焦虑的发生,而干预缰核HCN1的表达可能是EA调控神经病理性疼痛伴发精神障碍的机制之一。