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Scott R. Bauer MD ScM Peggy M. Cawthon PhD MPH Kristine E. Ensrud MD Anne M. Suskind MD MS John C. Newman MD PhD Howard A. Fink MD MPH Kaiwei Lu MS Rebecca Scherzer PhD Andrew R. Hoffman MD Kenneth Covinsky MD Lynn M. Marshall ScD For the Osteoporotic Fractures in Men Research Group 《Journal of the American Geriatrics Society》2022,70(4):1082-1094
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《Journal of vascular and interventional radiology : JVIR》2022,33(4):359-367.e8
PurposeTo review and to compare indirectly the outcomes of minimally invasive therapies for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia.Materials and MethodsA literature search via Medline and Cochrane Central databases was completed for randomized control studies published between January 2000 to April 2020 for the following therapies: Rezum, Urolift, Aquablation, and prostatic artery embolization (PAE). Data on the following variables were included: International prostate symptom score (IPSS), maximum urinary flow rate, quality of life, and postvoid residual (PVR). Standard mean differences between treatments were compared through a meta-analysis using transurethral resection of the prostate (TURP) to assess differences in treatment effect.ResultsThere was no significant difference in outcomes between therapies for IPSS at the 3, 6, and 12-month follow ups. Although outcomes for Rezum were only available out to 3 months, there were no consistently significant differences in outcomes when comparing Aquablation versus PAE versus Rezum. TURP PVR was significantly better than Urolift at 3, 6, and 12 months. No significant differences in minor or major adverse events were noted.ConclusionAlthough significant differences in outcomes were limited, Aquablation and PAE were the most durable at 12 months. PAE has been well studied on multiple randomized control trials with minimal adverse events while Aquablation has limited high quality data and has been associated with bleeding-related complications. 相似文献
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目的比较子宫内膜异位症(EM)合并子宫内膜息肉(EP)术后单独使用促性腺激素释放激素激动剂(GnRH-a)和GnRH-a联合左炔诺孕酮宫内节育系统(LNG-IUS)的疗效。方法选择2018年1月1日至2020年1月1日在安徽医科大学第一附属医院妇产科因EM合并EP接受宫腹腔镜联合保守性手术治疗的60例患者,按照随机数字表法分为观察组和对照组各30例,对照组术后单独予GnRH-a治疗,观察组予GnRH-a联合LNG-IUS治疗,随访1年,观察两组患者的痛经缓解情况、月经量及子宫内膜厚度变化情况、EM及EP复发情况。结果①两组均有一定的治疗效果,术后12个月两组的痛经程度、月经量及子宫内膜厚度较术前均下降(P<0.01);②术后12个月观察组痛经视觉模拟评分法评分[(1.97±1.03)分]低于对照组[(3.07±1.01)分],差异有统计学意义(P<0.01);③术后12个月观察组的月经量[(36.00±9.39)分]少于对照组[(82.07±10.82)分],差异有统计学意义(P<0.01);④术后12个月观察组的子宫内膜厚度[(2.69±1.21)mm]薄于对照组[(7.28±1.55)mm],差异有统计学意义(P<0.01)。⑤两组术后1年随访,观察组EM和EP复发率均低于对照组(3.33%比16.67%;0.00%比6.67%),但差异无统计学意义(P>0.05),观察组痛经症状复发率(0.00%比25.00%)及总复发率(3.33%比36.67%)低于对照组,差异有统计学意义(P<0.05,P<0.01)。结论GnRH-a联合LNG-IUS治疗EM合并EP疗效明确,可有效缓解痛经程度,减少患者的月经量,降低复发率,优于单用GnRH-a治疗。 相似文献
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目的探讨中药配方颗粒治疗肝郁痰凝型乳腺增生症的临床效果。方法将100例肝郁痰凝型乳腺增生症患者随机分为对照组与观察组,各50例。对照组接受常规中药饮片治疗,观察组采用中药配方颗粒治疗,比较两组的临床效果。结果两组的治疗总有效率无显著差异(P>0.05)。治疗后,两组的乳房疼痛、肿块大小、乳房肿块硬度评分均降低,且观察组低于对照组(P<0.05)。治疗后,两组的E2、PRL水平均降低,P水平均升高(P<0.05),但组间比较,差异不显著(P>0.05)。观察组患者认为调剂方式使用便捷、安全卫生、剂量准确、易于储存的比例均高于对照组(P<0.05)。结论中药配方颗粒治疗肝郁痰凝型乳腺增生症的临床效果显著,可有效控制疾病症状,且具有用药方便、安全卫生、剂量准确、易于储存的优点,临床实用性更强。 相似文献
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胆囊切除术是公认的胆囊良性疾病的治愈手段,国内外学术界对于手术适应证和手术时机已有明确共识。近年来,“保胆手术”治疗胆囊良性疾病颇受热议,一些医生将“保护胆囊”的学术观点等同于“保留胆囊”的手术技术,这种误解可能导致病人出现差异性的预后。因此,临床医师应明晰“保护胆囊”理念与“保胆手术”的差别,对胆囊良性疾病的诊疗原则有正确的理解和应用。 相似文献
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Hiroki Teragawa Chikage Oshita Yuichi Orita Kunihiro Hashimoto Hirofumi Nakayama Yuto Yamazaki Hironobu Sasano 《World Journal of Clinical Cases》2021,9(5):1119-1126
BACKGROUNDAdrenal incidentaloma (AI) has been frequently encountered in the clinical setting. It has been shown that primary aldosteronism (PA) or subclinical Cushing’s syndrome (SCS) are the representative causative diseases of AI. However, the coexistence of PA and SCS has been reportedly observed. Recently, we encountered a case of AI, in which PA and SCS coexisted, confirmed by histopathological examinations after a laparoscopic adrenalectomy. We believe that there were some clinical implications in the diagnosis of the present case.CASE SUMMARYA 58-year-old man presented with lower right abdominal pain with a blood pressure of 170/100 mmHg. A subsequent computed tomography scan revealed right ureterolithiasis, which was the cause of right abdominal pain, and right AI measuring 22 mm × 25 mm. After the disappearance of right abdominal pain, subsequent endocrinological examinations were performed. Aldosterone-related evaluations, including adrenal venous sampling, revealed the presence of bilateral PA. In addition, several cortisol-related evaluations showed the presence of SCS on the right adrenal adenoma. A laparoscopic right adrenalectomy was then performed. The histopathological examination of the resected right adrenal revealed the presence of a cortisol-producing adenoma, while CYP11B2 immunoreactivity was absent in this adenoma. However, in the adjacent non-neoplastic adrenal, multiple CYP11B2-positive adrenocortical micronodules were detected, showing the presence of aldosterone-producing adrenocortical micronodules. CONCLUSIONCareful clinical and pathological examination should be performed when a patient harboring AI presents with concomitant SCS and PA. 相似文献
9.
目的:分析我院内镜下治疗的16例十二指肠乳头腺瘤的临床资料,结合文献复习,总结临床诊治体会。方法:回顾性分析2015年5月-2018年9月于我院消化内镜中心治疗的16例十二指肠乳头腺瘤,其中男性10例,女性6例;平均年龄58.87岁(38~76岁)。肿物最大径平均值为1.27 cm(0.3~2.6 cm)。结果:16例患者均内镜下完成十二指肠乳头肿物切除,其中6例患者行内镜下胆胰管支架置入术;2例患者单独行胆管支架置入术;1例患者单独行胰管支架置入术。术后定期随访患者12~50月,均无复发及转移。结论:十二指肠乳头腺瘤在临床上属于罕见病例,具有癌变倾向,临床表现不典型;术前可通过胃镜取材病理判断肿物性质。对于十二指肠乳头腺瘤要做到早发现,早诊断,早治疗。相对外科手术,内镜下十二指肠乳头腺瘤切除术创伤小、并发症少、恢复快、费用低,是有效的临床治疗手段。 相似文献
10.
Yang Xiong Yangchang Zhang Jun Tan Feng Qin Jiuhong Yuan 《Translational andrology and urology》2021,10(1):384
BackgroundTo investigate the association between lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and metabolic syndrome (MetS) in aging Chinese males.MethodsA dataset that included 3,568 non-MetS cases and 1,020 MetS cases (after data cleansing) was downloaded from the China Health and Retirement Longitudinal Study (CHARLS). To balance the intergroup covariates, propensity score matching (PSM) was employed in the analyses. Univariate logistic regression and multivariate logistic regression were then performed to investigate the relationship between LUTS/BPH and MetS in aging Chinese males.ResultsBefore PSM, multivariate logistic regression showed that participants with MetS had a 1.47 times higher risk of LUTS/BPH compared to non-MetS cases in the final model (P<0.001). It also revealed that participants with low high-density lipoprotein (HDL), abdominal adiposity, or high triglycerides had a higher probability of LUTS/BPH [odds ratio (OR) =1.56 for low HDL; OR =1.50 for abdominal adiposity; and OR =1.48 for high triglyceride, P<0.001], while participants with hyperglycemia or hypertension had identical odds of LUTS/BPH (P>0.05). After PSM, 1,000 pairs were successfully matched. It was also found that MetS cases had a 1.60 times higher risk of LUTS/BPH compared to non-MetS cases (P<0.001), and participants with low HDL, abdominal adiposity, high triglycerides, or hyperglycemia had a higher likelihood of LUTS/BPH than their counterparts (P<0.001). However, the probability of LUTS/BPH in hypertensive patients remained similar to that in non-hypertensive patients (P>0.05).ConclusionsAging Chinese males with MetS had a higher probability of LUTS/BPH. Also, patients with low HDL, abdominal obesity, high triglycerides, or hyperglycemia had an increased risk of LUTS/BPH; however, this was not the case for hypertensive patients. 相似文献