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目的:观察异位性皮炎急性病损中嗜酸性粒细胞的脱颗粒蛋白主要碱性蛋白(MBP)的表达情况。方法:取40例异位性皮炎的急性病损,用抗人MBP抗体,应用免疫组化SAB-AP法进行染色。结果:异位性皮炎急性病损中MBP的表达因个体不同而有很大的差异,而且阳性表达主要见于真皮浅层,多呈颗粒状、红染。结论:在异位性皮炎病损中MBP的表达存在着异质性,并且急性病损中的表达形式也与慢性病损中的表达不同。 相似文献
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Lehtovirta-Morley LE Stoecker K Vilcinskas A Prosser JI Nicol GW 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(38):15892-15897
Nitrification is a fundamental component of the global nitrogen cycle and leads to significant fertilizer loss and atmospheric and groundwater pollution. Nitrification rates in acidic soils (pH < 5.5), which comprise 30% of the world's soils, equal or exceed those of neutral soils. Paradoxically, autotrophic ammonia oxidizing bacteria and archaea, which perform the first stage in nitrification, demonstrate little or no growth in suspended liquid culture below pH 6.5, at which ammonia availability is reduced by ionization. Here we report the discovery and cultivation of a chemolithotrophic, obligately acidophilic thaumarchaeal ammonia oxidizer, "Candidatus Nitrosotalea devanaterra," from an acidic agricultural soil. Phylogenetic analysis places the organism within a previously uncultivated thaumarchaeal lineage that has been observed in acidic soils. Growth of the organism is optimal in the pH range 4 to 5 and is restricted to the pH range 4 to 5.5, unlike all previously cultivated ammonia oxidizers. Growth of this organism and associated ammonia oxidation and autotrophy also occur during nitrification in soil at pH 4.5. The discovery of Nitrosotalea devanaterra provides a previously unsuspected explanation for high rates of nitrification in acidic soils, and confirms the vital role that thaumarchaea play in terrestrial nitrogen cycling. Growth at extremely low ammonia concentration (0.18 nM) also challenges accepted views on ammonia uptake and metabolism and indicates novel mechanisms for ammonia oxidation at low pH. 相似文献
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本文报告5例急性重症型和1例亚急性重症型肠道传播的非甲非乙型肝炎病人肝穿活检标本的电镜观察结果。5例急性重症型肝炎中3例死亡,2例恢复。死亡病人的肝细胞以溶解性和嗜酸性坏死表现为主,而恢复期的病人肝细胞内各种细胞器只残留轻微的变性改变。亚急性重症型肝炎病人的肝细胞以嗜酸性变为主,Disse间隙及肝窦内淤胆明显。 相似文献
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