2009-2019年西安市肺结核流行特征及治疗转归分析

目的 了解2009-2019年西安市肺结核的流行特征及治疗转归情况，为完善西安市肺结核防治策略提供依据。方法 收集2009-2019年《传染病信息管理系统》中登记的肺结核患者病案信息数据，通过描述性研究方法对肺结核流行病学特征和治疗转归情况进行分析。结果 2009-2019年间西安市肺结核年平均发病率为49.06/10万。郊县、郊区、城区肺结核年平均发病率分别为54.13/10万、47.46/10万和46.19/10万；男性发病率是女性的1.85倍。职业分布排在前5位的为农民（47.48%），家政、家务及待业（14.65%），离退人员（9.55%），学生（8.63%）和工人（5.23%）。利福平敏感或耐药性未知患者的成功治疗率平均为98.03%，利福平耐药患者治疗成功率为51.47%。结论 西安市近年来肺结核发病率和治疗率呈增长趋势，利福平耐药患者治疗成功率较低，要加强对重点人群的健康促进工作，加大肺结核发现力度及患者治疗管理工作。     

Performance of EAST in diagnosing inhalant allergens in children with allergic rhinitis

The performance of enzyme linked immunosorbent assays (EAST) for identifying six indoor allergens was evaluated using skin prick test (SPT) as reference tests in 154 children with allergic rhinitis. Sensitivity of EAST ranged from 9% (cat) to 54% (HDM) with specificity of 74%(cockroach) to 100% (cat) with an agreement ranged from 58 to 86%. Cut off values ?> ?0.35 kU/L showed best sensitivity and specificity. Our findings agree with extant literature which suggests that the ability of EAST to determine the precipitating allergen is moderate. Assays for definitively identifying the inhalant allergen are currently not available.     

LINC00205 promotes proliferation,migration and invasion of HCC cells by targeting miR-122-5p

Long non-coding RNAs (lncRNAs) have been identified as crucial regulators in the tumorigenesis and progression of hepatocellular carcinoma (HCC). Recently, long intergenic non-protein coding RNA 205 (LINC00205) has been identified as a prognostic biomarker in HCC. However, the biological role of LINC0205 and its potential molecular mechanism are poorly investigated. Here, we found that the expression of LINC00205 was dramatically up-regulated in HCC tissues compared to adjacent nontumor tissues. Furthermore, the level of LINC00205 in both Hep3B and Huh7 cells was prominently higher than that in normal hepatic cell line LO2. Notably, the high expression of LINC00205 was strongly correlated with tumor size ≥5 cm, venous infiltration and advanced tumor stages. Functionally, LINC00205 knockdown obviously repressed the proliferation, migration and invasion of Hep3B and Huh7 cells in vitro. An inverse correlation between LINC00205 and miR-122-5p was detected in HCC tissues. Interestingly, LINC00205 knockdown increased the level of miR-122-5p in both Hep3B and Huh7 cells. Mechanistically, luciferase reporter assay demonstrated LINC00205 acted as a competing endogenous RNA (ceRNA) by directly interacting with miR-122-5p. More importantly, miR-122-5p overexpression significantly restrained the proliferation, migration and invasion of HCC cells. Collectively, our study provides solid evidence to support the oncogenic role of LINC00205 in HCC, which may be benefit for the improvement of HCC therapy.     

西安市雁塔区机井水与城市集中供水水质分析

目的针对西安市雁塔区机井水的水质状况存在的问题，比较机井水与城市集中供水的水质质量，以加强对机井水用水企业单位的监管。方法收集西安市雁塔区2008、2009、2010年的水质检测报告156份，依据水源类型分为机井水（78份）和城市集中供水（78份），检测项目30项，采用SPSS13．0统计软件进行显著性统计分析。站果机井水中铁（1．78mg／L）、锰（0．33mg／L）、总硬度（672．25mg／L）、硫酸盐（110．68mg／L）、氯化物（134．23mg／L）、溶解性总固体（1279．00mg／L）、氟化物（1．06mg／L）、细菌总数（1．5×10^4CFU／mL）、大肠菌群（8MPN／100mL）的最高检测值高于国家生活引用水卫生标准；城市集中供水检测项目均符合国家生活引用水卫生标准；总硬度（t=12．09，P〈0．05）、硫酸盐（t=5．69，P〈0．05）、氯化物（t=9．043，P〈0．05）、溶解性总固体（t=10．57，P〈0．05）、氟化物（t=2．08，P=0．041〈O．05）、细菌总数（t=2．47，P=0．016〈0．05）、大肠菌群（t=2．20，P=0．031〈0．05）7项检测项目在机井水与城市供水组的水质上存在显著性差异。结论西安市雁塔区机井水的水质状况劣于城市集中供水，应切实加强对机井水用水企业单位的监管，加快城市集中供水的全区覆盖面。     

喜炎平联合万应胶囊治疗疱疹性咽峡炎疗效分析

目的探讨喜炎平联合万应胶囊治疗疱疹性咽峡炎的临床疗效。方法对70例疱疹性咽峡炎患儿随机分为2组,治疗组34例,对照组36例。治疗组应用喜炎平注射液剂量2.5～5mg/(kg·d),最大剂量不超过200mg/d,分2次肌注,另用喜炎平注射液5mg/kg,加入生理盐水20mL,用超声雾化器进行雾化吸入,1次/d,联合万应胶囊0.15,口服,2次/d,;对照组应用病毒唑10mg/(kg·d)静点,其余治疗相同,3～5d为1个疗程。结果治疗组总有效率与对照组比较,差异有显著统计学意义(P<0.01)。结论喜炎平联合万应胶囊综合治疗疱疹性咽峡炎疗效满意。