SIAM-Like Phenomenon Caused by Low Doses of Alcohol

Background: Swift increase in alcohol metabolism (SIAM) is usually evoked by a large dose of ethanol, which is often demonstrated by an abrupt increase in oxygen uptake. SIAM was induced by low doses of ethanol and evaluated by pharmacokinetic analyses of ethanol and its metabolites. Methods: Rabbits were initially administered 1.0 g/kg of ethanol solution and the same dose was given to the bolus group 6 hours after the first injection. The infusion group was administered 0.25 g/kg/h of ethanol 2 hours after the first injection. Blood concentrations of ethanol, acetaldehyde, and acetate were then determined and comparisons were made using pharmacokinetic parameters. Results: A significantly higher ethanol elimination rate was observed after re-administration of ethanol to the bolus group. Other pharmacokinetic parameters were unaffected. The concentration at steady state (Css) for the infusion group was stable. A significantly higher level of mean residence time (MRT) in blood acetaldehyde was observed for the bolus group, whereas no MRT changes were observed for the infusion group. A significantly higher level of blood acetate Css was observed after re-administration of ethanol to the bolus group, following the changes in area under concentration and MRT. No Css changes were observed for the infusion group. The Css of acetate at stage 2 was significantly higher for the bolus group, compared to the infusion group. Conclusion: Low doses of ethanol enhanced alcohol metabolism in rabbits, according to a pharmacokinetic analysis of circulating ethanol concentrations. Simultaneous analyses of its metabolites followed the kinetic of ethanol.     

膝关节骨性关节炎髌下脂肪垫在中药治疗前后的CT变化研究

目的:通过对比膝骨性关节炎(knee osteoarthritis,KOA)膝关节髌下脂肪垫治疗前后CT图像的变化,探讨中医药治疗KOA的疗效。方法:将130例KOA患者随机分为2组,治疗组65例给予健步通络熏蒸液熏洗,30min/d,10d为1个疗程,共3个疗程;对照组65例每6d关节内注射玻璃酸钠30mg,共5次;2组皆治疗30d。治疗前后均行膝关节CT扫描,观察治疗前后髌下脂肪垫的变化。结果:治疗组经治疗后髌下脂肪垫的前后径、内外径、上下径均有缩小,密度均有降低,优于对照组;治疗组总有效率(83.08%)优于对照组(76.92%),差异有统计学意义(P0.05)。结论:对比膝关节髌下脂肪垫CT图像的变化是评价中医药治疗KOA疗效的有效方法。     

In My Rearview Mirror

Understanding how young teen girls use music to navigate the emotional dramas of first love presents an important insight into the part media play in teens’ processes of identity formation. Through analysis of forum postings on the official Taylor Swift website, I explore how teen girls “talk” about Swift's music in an effort to understand how these girls use the lyrics of Swift songs in a prospective remembering of their future relationships. While many of Swift's lyrics reinforce social norms around the search for a Prince, I argue that they also highlight the complexity of relationships and foster a sense of nostalgia in reverse for young teen girls. My analysis draws attention to the integral role of this online forum as a safe space for the self-disclosure of feelings and as a key mechanism of emotional support during the teen years.     

超声快速平移偏转法在中晚孕期胎儿外耳廓异常筛查中的应用价值

目的探讨超声快速平移偏转法筛查中晚孕期胎儿外耳廓异常的应用价值。方法应用超声快速平移偏转法筛查5533例中晚孕期胎儿外耳廓异常情况,并与引产后或产后外耳廓的结果进行对照分析。结果 5533例胎儿中,超声检出外耳廓异常共计41例,其中小耳畸形8例,附耳18例,外耳廓卷曲15例。14例外耳廓仅能显示一侧,8例双侧外耳廓均未显示,胎儿双侧外耳廓显示率99.6%。引产或产后证实外耳廓异常38例,其中小耳畸形8例,附耳29例,外耳廓卷曲1例。快速平移偏转法产前超声筛查胎儿外耳廓形态异常的敏感性为71.05%,特异性为99.75%。结论快速平移偏转式超声扫描法在中晚孕期胎儿外耳廓畸形筛查中具有重要的临床价值。