Necessary optimality conditions for a generalized problem of production scheduling

This communication concerns a derivation and study of necessary optimality conditions for production scheduling. The continuous-time optimal control problem is stated for the analysis of extremal behaviour of a flexible flow shop. This is accomplished by means of the maximum principle, which is applied to the problem with irregular constraints and three typical forms of objective function.     

情感韵律加工的单侧化

首先阐述韵律加工的神经机制的相关假说,然后从情感韵律的知觉和产生两方面,回顾大脑半球在情感韵律加工中的单侧化优势的相关研究。大多数研究表明,情感韵律的加工主要在右半球,此外,皮层下组织在情感韵律产生和知觉中起着重要作用。     

加快医疗保险和医药卫生体制三项改革步伐——在国务院联合督查组西北片座谈会上的讲话(摘要)

总结了西北各省、区医疗保险和医药卫生体制三项改革的进展情况,分析了目前存在的问题:各地改革发展不平衡,有的尚存在观望等待思想和畏难情绪;有的缺乏符合本地实际的可操作性实施方案;有的有关管理机构和人员尚未完全到位;宣传教育广度、深度不够;改革进程与中央要求及上报计划完成目标尚有一定差距。对今后工作提出几点意见:进一步解放思想,提高认识,更新观念;加强对文件的学习、宣传和培训;深入调研,制定符合本地实际情况,具有操作性配套政策和实施方案;抓点带面,搞好试点,总结经验,积极推广;加强部门协调,团结协作,同步推进“三项”改革;加强领导,加快工作进度。     

基于柯布-道格拉斯生产函数的我国卫生资源实证分析

卫生资源配置是形成卫生生产能力的基石，它包括增量的有效配置和存量的合理调整。作者基于柯布一道格拉斯生产函数的计算方法和分析原理，结合我国卫生领域的历史数据，采用最小二乘法和方差分析等方法拟合出卫生资源与产出能力相关的多元线性回归模型，实证分析我国卫生资源配置现状。结果表明，我国卫生人力资源投入不足，其对产出的贡献率偏低，而且卫生资源配置总体上规模效益递减。     

新疆生产建设兵团基层卫生机构医生工作倦怠的现状及分析

目的了解新疆生产建设兵团基层医生工作倦怠现况,为稳定西部基层卫生队伍提供理论依据。方法采用多阶段分层抽样方法,用马斯勒倦怠问卷对372名医生进行调查。结果有89.2%的医生出现了中度以上的倦怠感;高工作要求、内部及外部工作资源的缺失导致＂情绪衰竭＂、＂消极工作＂和低＂个人成就感＂的倦怠症状。结论需要从长远规划上,通过定向培养、进修培训、对口支援等措施,降低基层卫生人员的倦怠水平。     

Sol Particle Immunoassay (SPIA)

We describe the use of inorganic (metal) colloidal particles as a label for immunoassays. Dose-response curves for human placental lactogen (HPL) and human chorionic gonadotrophin (HCG) were obtained with sandwich immunoassays, using conjugates consisting of antibody-coated colloidal gold or silver particles. Several techniques were used to measure the amount of bound conjugate, viz. colorimetry and carbon rod atomic absorption spectrophotometry (CRAAS). At higher antigen concentrations the results of the assay could be read by the naked eye.

Using gold particles as label and CRAAS as detection method, we found a detection limit for a sandwich HPL sol particle immunoassay (SPIA) of 1,4 pmol/l, which was equal to that of an optimalized competitive radioimmunoassay. When using a colorimeter the detection limit for HPL of this SPIA was 5,4 pmol/l, which was superior to that of a corresponding sandwich enzyme-immunoassay (EIA). HPL and HCG were also simultaneously determined, using micro-titration plates, coated with a mixture of anti-HPL and anti-HCG, and a mixture of silver particle anti-HPL conjugate and gold particle anti-HCG conjugate. CRAAS was used to measure the bound amount of silver and gold conjugate. This simultaneous assay requires more work in order to obtain better sensitivities.     

A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines

This review provides an outlook of the medical applications of immunomodulatory compounds taken from Pleurotus and proposes this fungus as a convenient host for the development of innovative vaccines. Although some fungal species, such as Saccharomyces and Pichia, occupy a relevant position in the biopharmaceutical field, these systems are essentially limited to the production of conventional expensive vaccines. Formulations made with minimally processed biomass constitute the ideal approach for developing low cost vaccines, which are urgently needed by low-income populations. The use of edible fungi has not been explored for the production and delivery of low cost vaccines, despite these organisms’ attractive features. These include the fact that edible biomass can be produced at low costs in a short period of time, its high biosynthetic capacity, its production of immunomodulatory compounds, and the availability of genetic transformation methods. Perspectives associated to this biotechnological application are identified and discussed.     

固定式眼科冰袋套的制作与应用

冰袋冷敷常规使用于眼科上睑下垂病人行额肌瓣悬吊术或眼险重建术后。一般手术后应持续使用48h,能有效预防术后上眼睑的水肿。目前使用的化学冰袋体积大,份量重,无法固定,特别是对于年龄较小且配合不佳的患儿,无法达到冷敷满意的效果。为此,我们研制了一款固定式眼科小冰袋,在临床上通过对30例患者的使用（其中成年人20例,儿童10例）,效果满意,现报告如下。     

实验动物饲料硬度和粒度对饲料利用率的影响

本文简述了饲料粒度和硬度对饲料生产和对实验动物的影响.适度的粉碎粒度可以有效控制生产成本,适当的饲料粒度和硬度可以提高实验动物对饲料的利用率.