首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   167466篇
  免费   12408篇
  国内免费   5295篇
耳鼻咽喉   1056篇
儿科学   3982篇
妇产科学   1840篇
基础医学   12689篇
口腔科学   2101篇
临床医学   20658篇
内科学   23554篇
皮肤病学   1309篇
神经病学   12015篇
特种医学   7120篇
外国民族医学   7篇
外科学   26299篇
综合类   30088篇
现状与发展   6篇
一般理论   10篇
预防医学   15852篇
眼科学   4260篇
药学   14291篇
  101篇
中国医学   5662篇
肿瘤学   2269篇
  2024年   452篇
  2023年   2634篇
  2022年   4857篇
  2021年   6841篇
  2020年   6229篇
  2019年   7570篇
  2018年   7281篇
  2017年   6301篇
  2016年   5552篇
  2015年   5384篇
  2014年   10852篇
  2013年   11780篇
  2012年   9689篇
  2011年   10616篇
  2010年   8637篇
  2009年   7886篇
  2008年   7819篇
  2007年   7525篇
  2006年   6979篇
  2005年   5696篇
  2004年   4700篇
  2003年   4061篇
  2002年   3325篇
  2001年   3002篇
  2000年   2450篇
  1999年   2098篇
  1998年   1758篇
  1997年   1662篇
  1996年   1348篇
  1995年   1270篇
  1994年   1060篇
  1993年   830篇
  1992年   765篇
  1991年   636篇
  1990年   587篇
  1989年   523篇
  1988年   471篇
  1985年   1303篇
  1984年   1783篇
  1983年   1360篇
  1982年   1417篇
  1981年   1373篇
  1980年   1196篇
  1979年   1037篇
  1978年   819篇
  1977年   566篇
  1976年   720篇
  1975年   606篇
  1974年   506篇
  1973年   467篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
The value of adding simeprevir (SMV) vs placebo (PBO) to peginterferon and ribavirin (PR) for treatment of chronic hepatitis C virus infection was examined using patient‐reported outcomes (PROs); further, concordance of PROs with virology endpoints and adverse events (AEs) was explored. Patients (= 768 SMV/PR,= 393 PBO/PR) rated fatigue (FSS), depressive symptoms (CES‐D) and functional impairment (WPAI: Hepatitis C Productivity, Daily Activity and Absenteeism) at baseline and throughout treatment in three randomised, double‐blind trials comparing the addition of SMV or PBO during initial 12 weeks of PR. PR was administered for 48 weeks (PBO group) and 24/48 weeks (SMV group) using a response‐guided therapy (RGT) approach. Mean PRO scores (except Absenteeism) worsened from baseline to Week 4 to the same extent in both groups but reverted after Week 24 for SMV/PR and only after Week 48 for PBO/PR. Accordingly, there was a significantly lower area under the curve (baseline–Week 60, AUC60) and fewer weeks with clinically important worsening of scores in the SMV/PR group at any time point. Incidences of patients with fatigue and anaemia AEs were similar in both groups, but FSS scores showed that clinically important increases in fatigue lasted a mean of 6.9 weeks longer with PBO/PR (P < 0.001). PRO score subgroup analysis indicated better outcomes for patients who met the criteria for RGT or achieved sustained virological response 12 weeks post‐treatment (SVR12); differences in mean PRO scores associated with fibrosis level were only observed with PBO/PR. Greater efficacy of SMV/PR enabled reduced treatment duration and reduced time with PR‐related AEs without adding to AE severity.  相似文献   
4.
《Urological Science》2015,26(2):144-146
Hydronephrosis with an undetermined pathology is a common condition detected in imaging studies. In urological clinical practice, it is a persistent dilemma to predict whether this condition will progress to result in the deterioration of renal function. Perfusion pressure flow study of the upper urinary tract, known as the Whitaker test, provides an alternative diagnostic tool for solving this condition. Perfusion pressure flow study has been criticized for its invasiveness, nonphysiological approach, and inconsistency in predicting outcomes. However, it continues to be used to evaluate difficult or equivocal cases and to provide an objective assessment of the upper urinary tract.  相似文献   
5.
6.
目的:比较经鼻导管高流量吸氧(HFNC)与经鼻气道正压通气(nCPAP)在重症毛细支气管炎呼吸支持中的应用价值,为临床治疗方案的选择提供参考。方法:选取2016年12月至2018年12月我院儿科收治的重症毛细支气管炎患儿90例,采用随机数字表法分为观察组和对照组各45例。两组患儿入院后均给予常规综合治疗以保证呼吸道通畅,在此基础上观察组采用HFNC治疗,对照组采用nCPAP治疗,比较两组患儿治疗前和治疗24 h后呼吸频率、经皮血氧饱和度(TcSO2)、呼吸窘迫评分体系(CSS)评分、动脉血氧分压(PaO2)等呼吸相关指标及治疗前后临床症状体征改善情况。结果:两组患儿治疗24 h后呼吸频率、CSS评分均降低,且观察组降低程度更大,TcSO2、PaO2于治疗24 h后升高,观察组升高幅度较对照组明显;治疗后两组患儿咳嗽及肺部湿啰音、肺部炎症情况均改善,观察组症状体征消失时间早于对照组,差异均有统计学意义(P<0.05)。结论:重症毛细支气管炎患儿采用HFNC治疗可明显改善通气功能和临床症状,治疗效果优于nCPAP治疗,可扩大样本量进一步观察。  相似文献   
7.
8.
Chronic obstructive pulmonary disease (COPD) is a significant health problem in developed countries. We aimed to estimate the prevalence of COPD in a single Spanish healthcare area. We also aimed to assess if there are any differences in prevalence and spirometry use among primary care services by utilizing already registered information. We designed a cross-sectional study to determine the prevalence of COPD and the performance of spirometries in each primary care service. A total of 8,444 patients were diagnosed with COPD, with a prevalence of 2.6% for individuals older than 39 years. The prevalence increased with age and was much higher in men. Significant heterogeneity was found in the prevalence of COPD and spirometry use among primary care services. COPD was underdiagnosed and there was wide variability in spirometry use in our area. Greater efforts are needed to diagnose COPD in order to improve its clinical outcomes and to refine registries so that they can be used as reliable sources of information  相似文献   
9.
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号